Service information
The OECD 490: Mouse Lymphoma Assay (MLA) Test is one of the mammalian gene mutation assays available and is frequently utilised in most genotoxicity testing regulatory frameworks. Able to detect point mutations, clastogens, and, in some cases, aneugens, the mouse lymphoma assay has the capability to detect a broad spectrum of genotoxic effects.
The mouse lymphoma assay was previously included in OECD guideline 476 for mammalian cell gene mutation but was separated into the new OECD 490 guideline in 2015. Our study director has been working on mouse lymphoma assays for over 14 years, gaining extensive experience in running this study type within the industry.
| Test system | L5178Y TK+/--3.7.2C |
| OECD guideline | 490 |
| Test Format | 3 hr +/- S9, and extended exposure -S9 Duplicate cultures are used |
| Typical test item requirements | Typically 5 g |
| Endpoint | Mammalian gene mutation |