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Using multiple biomarkers within a single flow cytometry-based experiment, the MultiFlow® assay can distinguish between clastogenic and aneugenic modes of action and identify potentially misleading positives that might be secondary to cytotoxicity. This assay has considerable utility as a follow-up to positive in vitro results or as a primary screening tool, requiring low amounts of compound to generate fast predictions of mechanism and mode of action.

Advantages for Screening

  • High throughput
  • Low compound mode of action prediction
  • Enables screening for aneugens, clastogens and non-genotoxic substance
Multiflow
Test Cell LineTK6
Study DesignTypically, induced rat liver S9, other sources available.
Sampling at 4hr & 24hr time points
Biomarkers: p53, H2AX, H3, Polyploidy
Typical test item requirements<20 mg
Study Duration< 3 Weeks
EndpointMultiple biomarkers predict genotoxicity