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Neuroinflammation is a complex reaction of the immune system to infections or injuries within the central nervous system. It plays a major role both in physiological defense and pathological processes. Neuroinflammation involves the activation of various immune cells, including microglia and astrocytes and the release of several signaling molecules.

While neuroinflammation serves as a protective mechanism against threats like pathogens or toxins, its dysregulation can contribute to the pathogenesis of various neurological disorders, including multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and others.

Neurodegenerative disorders, autoimmune diseases, and traumatic brain injuries are associated with chronic neuroinflammation and consequently long-standing activation of immune cells and release of proinflammatory cytokines. Furthermore, neuroinflammation leads to increased oxidative and nitrosative stress in different cell types. Therefore, neuroinflammation represents a promising target for potential therapeutic compounds, not only in the above-mentioned diseases but also in a variety of other indications.

Scantox offers a wide range of in vitro models of neuroinflammation with high translational value to facilitate the transition to the next preclinical stages. We perform experiments to determine the beneficial effects of potential therapeutic compounds on a regular basis and in a wide range of cell systems using established protocols and assays.

Neuroinflammation can be stimulated in different types of cell culture models using pro-inflammatory agents, like lipopolysaccharide (LPS). At Scantox, we can progressively monitor the resulting cytokine release within the same cultures by single or multiplex analyses, using the Mesoscale Discovery platform, which allows simultaneous measurement of up to 10 cytokines from a single sample, with a selection of multiple different cytokines to suit your needs. Furthermore, we offer assays to quantify inflammasome components, including NLRP3, across various cell systems.

Real-time assessment of phagocytosis, using pHrodo™ staining has been established for Aβ1-42 as a model for AD, using the IncuCyte live cell imaging system in various microglial cultures. As the field of induced pluripotent stem cells (iPSCs) and iPSC-derived cell types continues to grow, we continuously develop new protocols to explore neuroinflammation’s intricacies. Furthermore, we are happy to discuss customized approaches for your next neuroinflammation study.

General Toxicology

Scantox offers general toxicology studies in both rodents and a non-rodents, and all technical staff are highly experienced and experts in handling and dosing of animals. Within the field of minipig toxicology Scantox is globally considered the leading expert.
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Scantox offers a comprehensive full bioanalytical package of LCMS/MS method development, validation, and sample analysis for both exploratory and regulatory studies. We are experts in LCMS/MS bioanalytical method development and validation for the quantification of small molecules and peptides within a variety of different matrices.
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From the corporate headquarters in Denmark and subsidiaries in Europe, Scantox is today serving customers all over the world. Scantox is world known for high quality data, on time deliveries, and high ethical standards.
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Let Scantox be the next step in your professional career! We are always looking for new talent, and we currently have a number of open positions at our sites. We also always welcome unsolicited applications, so don’t hesitate to get in touch if you would like to join a team great team!
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