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Alzheimer’s Disease In Vitro Models

Alzheimer’s disease (AD) is one of the most devastating neurodegenerative diseases. Aggregation of amyloid-beta peptide (Aβ) into cytotoxic oligomers and fibrills is one of the major hallmarks in AD. These pathological depositions in the brain are thought to be one of the main causes for the observed progressive cognitive decline in AD patients.

Interfering with Aβ aggregation is an inevitable strategy in the development of novel therapeutic approaches. Reliable in vitro models are needed, which are capable of showing direct effects of compounds on Aβ oligomer formation and thus, a beneficial impact on cell viability.

General Toxicology

Scantox offers general toxicology studies in both rodents and a non-rodents, and all technical staff are highly experienced and experts in handling and dosing of animals. Within the field of minipig toxicology Scantox is globally considered the leading expert.
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Rodent models: oncology, infection (BSL2 and BSL3), inflammation, diabetology and several rare diseases within the orphan drug indications. Porcine models: established models of dermatology and wound healing and operation facilities for proof of concept studies that involves implants and surgical intervention.
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Scantox offers a comprehensive full bioanalytical package of LCMS/MS method development, validation, and sample analysis for both exploratory and regulatory studies. We are experts in LCMS/MS bioanalytical method development and validation for the quantification of small molecules and peptides within a variety of different matrices.
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From the corporate headquarters in Denmark and subsidiaries in Europe, Scantox is today serving customers all over the world. Scantox is world known for high quality data, on time deliveries, and high ethical standards.
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