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Parkinson’s Disease In Vitro Models

Parkinson’s disease (PD) is a slowly progressive neurodegenerative disease clinically characterized by progressive motor impairment in affected people. Synaptic and axonal degeneration is followed by loss of dopaminergic neurons in the substantia nigra leads to reduced levels of dopamine in the nigrostriatal circuitry. Besides dopaminergic cell loss, intracellular formation of Lewy bodies, consisting predominantly of aggregated alpha-synuclein, has been suggested to be crucial in the pathogenesis of this disease.

PD is a complex, multifactorial disease in which different factors concur to the pathogenic process. In vitro models (established cell lines, primary cell cultures or lesion models) offer the advantage of a controlled environment favorable for exploring single pathogenic mechanisms and the genes/proteins involved.

On the cellular level, research in PD focuses on:

  • Neurotoxicity (MPP+, 6-OHDA, BSO,…)
  • Excitotoxicity (NMDA, glutamate,…)
  • Mitochondrial dysfunction
  • Defects in protein degradation

Scantox offers several cellular solutions to model PD pathology in vitro:

IND-Enabling Capabilities

We develop clear customized research programs for small molecule assessment, conduct tailored preclinical studies in line with IND requirements and Good Laboratory Practice (GLP) standards, and provIND-Enabling Capabilitieside high-quality data on time that guides your decisions.
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Manufacturing support services

Scantox has a strong track record of supporting pharma and biotech in a variety of services both in a consulting role and as the pharmaceutical development partner undertaking all CMC development activities
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Scantox offers a comprehensive full bioanalytical package of LCMS/MS method development, validation, and sample analysis for both exploratory and regulatory studies. We are experts in LCMS/MS bioanalytical method development and validation for the quantification of small molecules and peptides within a variety of different matrices.
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Let Scantox be the next step in your professional career! We are always looking for new talent, and we currently have a number of open positions at our sites. We also always welcome unsolicited applications, so don’t hesitate to get in touch if you would like to join a team great team!
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