In the intricate realm of biomedical research, the pursuit of new therapeutic interventions demands rigorous evaluation of safety and efficacy through specialized studies. Exploratory toxicology assesses potential adverse effects of compounds, while safety pharmacology explores their impact on critical physiological systems. Pharmacokinetics examines how substances are absorbed, distributed, metabolized, and excreted in the body, informing dosing and delivery strategies.
The range of available models comprises:
- Genetic or lesion-induced cell culture models for different indications using transgenic and non-transgenic cell lines allowing for multiple applications and analyses.
- Primary rat and mouse microglia and astrocytes and central nervous system neurons of different developmental stages, derived of embryos and earl postnatal pups from wild type or a variety of in-house bred transgenic rodent models.
- Microglia isolated from adult mouse brains using Magnetic Activated Cell Sorting (MACS) and adult bone marrow-derived macrophages (BMDM)
- Organotypic brain slices of specific brain parts, including but not limited to hippocampus and cerebellum, offering a physiologically representative system to study neurodegenerative processes.
- Induced pluripotent stem cells (iPSCs) and iPSC-derived differentiated cell types, providing a versatile platform for disease modeling and drug screening.
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