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Cell Culture Models

Scantox is specialized in functional screening of test compounds using a variety of cell culture models, including primary neurons from different species and various cell lines. We are dedicated to supporting you in any in vitro research project.

Our cell culture workflow is highly adaptable and tailored to meet your specific requirements. You can choose your preferred entry point in the process. Whether you provide us with your own cells of interest or select from our diverse collection of in-house cell culture models, we are equipped to accommodate your preferences. Additionally, we offer genetic modification services for cell systems upon request.

To replicate neurodegenerative conditions or study rare diseases, we can introduce specific lesions or modifications to cells, allowing to create relevant models for your research objectives. We conduct screenings using the compounds you provide, and we can help in planning and conducting any cell culture experiments.

Scantox provides a wide range of established reference compounds that can be used to compare drug efficacies, or you can provide us with specific reference compounds customized to your experiment. Throughout the process, we perform comprehensive sample processing and evaluate state of the art readouts.

Upon request, we handle the analysis of your experiments and deliver detailed study reports. You can rely on our expertise and commitment to provide valuable insights for your in vitro research projects.

Contact us today to set up your next in vitro study.

Cell Culture Workflow
Custom-tailored research services for your specific needs

Cell Culture Workflow
Embryonic and Postnatal Rat and Mouse Neurons
  • Hippocampal neurons
  • Cortical neurons
  • Dopaminergic neurons from the ventral mesencephalon
  • Sensory neurons from dorsal root ganglia (DRG)
  • Cerebellar granule cells
Rat and Murine Glial Cultures and other primary cells
  • Astrocytes
  • Microglia
  • Bone marrow-derived macrophages (BMDM)
Embryonic Chicken Neurons
  • Mesencephalic neurons
  • Telencephalic neurons
  • SH-SY5Y neuroblastoma cells
  • RN (B103) rat neuroblastoma cells
  • Neuro-2a murine neuroblastoma cells
  • BV-2 murine microglial cells
  • Patient-derived human fibroblasts from
    • Parkinson’s disease
    • Leber’s hereditary optic neuropathy (LHON)
    • Friedreich’s ataxia (FRDA)
    • Gaucher disease
    • Huntington’s disease
  • HepG2 cells
  • PC12 cells
  • ARPE-19 cells
  • Hela cells
  • CHO cells
  • SH-SY5Y overexpressing Tau441-V337M/R406W cells
  • SH-SY5Y overexpressing Tau441-P301L cells
  • SH-SY5Y overexpressing truncated Tau441
  • H4 cells overexpressing human APP with the Swedish and London mutation
  • RN cells overexpressing APP751
  • RN cells overexpressing APP751 with Austrian mutation
  • SH-SY5Y and RN overexpressing wild type α-synuclein or synuclein A53T
  • SH-SY5Y cells overexpressing β-synuclein
  • SH-SY5Y overexpressing wild type TARDBP43 (TDP43)
  • Cultivation and treatment of iPSC-derived neurons, astrocytes, and microglia from well-known vendors can be performed for various applications.
  • Co-cultivation methods and 2D as well as 3D models are constantly improved to provide assays in complex systems, closest to in vivo situation.
  • Hippocampal, cerebellar, or total organotypic brain slices from mouse pups can be cultivated and manipulated in medium- to high-through put applications.
  • Application of various in vitro and in vivo assays using lentiviral (LV) or adeno-associated viral vectors (AAV).

Animal Models

Scantox is highly experienced in generating, characterizing, and maintaining transgenic disease models and using them for drug testing projects for more than 20 years.
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histology services

Scantox offers a full set of histology services ranging from collection of tissue samples to delivering study reports that contain all experimental procedures and their outcome.
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Scantox Department of Translational Medicine offers a selection of molecular biological methods for the investigation of various diseases. The unit supports in vitro and in vivo studies performed at Scantox.
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