Generation of amyloid-beta peptide (Aβ) species and their aggregation into highly neurotoxic oligomers and fibrils is one of the major hallmarks of Alzheimer’s disease (AD).
The A4 (Amorfix Aggregated Abeta Assay) – exclusively licensed to Scantox – serves as a unique screening tool, which enables the fast, highly sensitive and cost efficient detection of Aβ oligomers in diverse biological samples.
![A4-Assay-1-1 A4-Assay Workflow](https://scantox.com/wp-content/uploads/2024/05/A4-Assay-1-1-scaled.jpg)
Importantly, the A4 has translational value due to its unmatched sensitivity and applicability in various sample types. The same method can be used to:
- determine the mechanism of action and to identify your lead compound in an in vitro screening.
- detect Aβ oligomers in samples from transgenic animal models.
- measure Aβ oligomers in clinical samples.
Assay format:
- 96 well
Read-out:
- Electrochemiluminescence
Application:
- Brain homogenates
- CSF
- In vitro aggregated Aβ
- Cell culture samples
Species:
- Any
![Assay Chart](https://scantox.com/wp-content/uploads/2024/05/A4-Assay-Fig1-1024x735.jpg)