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Amorfix Aggregated Aβ Assay (A4 Assay)

Generation of amyloid-beta peptide (Aβ) species and their aggregation into highly neurotoxic oligomers and fibrils is one of the major hallmarks of Alzheimer’s disease (AD).

The A4 (Amorfix Aggregated Abeta Assay) – exclusively licensed to Scantox – serves as a unique screening tool, which enables the fast, highly sensitive and cost efficient detection of Aβ oligomers in diverse biological samples.

A4-Assay Workflow

Importantly, the A4 has translational value due to its unmatched sensitivity and applicability in various sample types. The same method can be used to:

  • determine the mechanism of action and to identify your lead compound in an in vitro screening.
  • detect Aβ oligomers in samples from transgenic animal models.
  • measure Aβ oligomers in clinical samples.
Assay format:
  • 96 well
Read-out:
  • Electrochemiluminescence
Application:
  • Brain homogenates
  • CSF
  • In vitro aggregated Aβ
  • Cell culture samples
Species:
  • Any