Scantox offers the following mouse models—developed by The Michael J. Fox Foundation (MJFF) and its partners—and can perform your studies in them. To save researchers time and resources, MJFF makes a number of tools available to the scientific community with quick delivery and at low cost.
| Target | Common Name | Allele Type | JAX Strain | Description | Active Link |
|---|---|---|---|---|---|
| LRRK1 | LRRK1 KO | Knockout | 16120 | knockout exons 24 throught 29 of Lrrk1 | Strain 016120 |
| LRRK1 | LRRK1 KO | Knockout | 22880 | knockout exons 24 throught 29 of Lrrk1, no Pde6b | Strain 022880 |
| LRRK1 and LRRK2 | LRRK1/2 double KO | 16122 | knockout exons 24 throught 29 of Lrrk1 and knockout exons 39 throught 40 of Lrrk2 | Strain 016122 | |
| LRRK2 | BAC Human LRRK2 wildtype | Knockout | 13725 | BAC transgene expresisng WT LRRK2 enodgenouse promotor | Strain 013725 |
| LRRK2 | BAC Human LRRK2 R1441G | Transgenic | 18786 | BAC LRRK2(R1441G) enodenous promotor | Strain 018786 |
| LRRK2 | BAC Human LRRK2 G2019S | Transgenic | 18785 | BAC LRRK2 (G2019S) transgene | Strain 018785 |
| LRRK2 | LRRK2 KO | Transgenic | 16121 | knockout exons 39 throught 40 of Lrrk2 | Strain 016121 |
| LRRK2 | LRRK2 D1994A KI | Knockout | 21830 | D1994A point mutation in Lrrk2 | Strain 021830 |
| LRRK2 | LRRK2 T1348N KI | Knockin | 21829 | T1348N point mutation in Lrrk2 | Strain 021829 |
| LRRK2 | LRRK2 A2016T KI | Knockin | 21828 | A2016T point mutation in Lrrk2 | Strain 021828 |
| SNCA | BAC Human alphasynuclein wildtype | Knockin | 18442 | BAC murine promotor Human WT SNCA | Strain 018442 |
| SNCA | mThy-1 Human alpha-synuclein | Transgenic | 16936 | Murine Thy1 promotor, human WT SNCA | Strain 016936 |
| SNCA | mThy-1 Human alpha-synuclein | Transgenic | 17682 | Murine Thy1 promotor, human WT SNCA | Strain 017682 |
| SNCA | Alpha-synuclein KO | Knockout | 16123 | knockout exons 1 through 4 of murine SNCA | Strain 016123 |
| Eif4g1 | Eif4g1 R1207H | Knockin | 24521 | R1207H in exon 24, as well as loxP sites flanking exons 24 to 28. Crebmediated recombination removes exon 24 to 28 resulting in null allele. | Strain 024521 |
| Eif4g1 | Eif4g1 KO | Conditional Knockout | 21827 | LoxP sites flanking exons 24 to 28. Creb-mediated recombination removed exon 24 to 28 resulting in null allele. | Strain 021827 |
| VPS35 | VPS35 D620N KI | Knockin | 23409 | D620N mutation in exon 15 | Strain 023409 |
| VPS35 | VPS35 D620N KIfloxΔneo Vps35 | Conditional Knockout | 21807 | Cre recombinase inducible D620N mutation in exon 15 | Strain 021807 |
| GBA | GBA D409V KI | Knockin | 19106 | Gba D427V mutant protein corresponse to D409V | Strain 019106 |
