Service information
An additional offering from Scantox is the OECD 474: In Vivo Micronucleus Assay Test, which allows the testing of clastogenicity and aneugenicity in vivo. The in vivo micronucleus assay is the most commonly used in vivo genotoxicity study type (e.g., pharmaceutical and agrochemical active ingredient registrations) and is typically used as a follow-up for in vitro micronucleus or in vitro chromosome aberration positives to determine if the observed in vitro activity is expressed in vivo.
Working within the facilities at Alderley Park, Scantox can deliver guideline-compliant GLP in vivo micronucleus studies. Together with GLP-compliant partners, analytical services to demonstrate systemic exposure and test item formulation analysis can also be provided.
Our study director and the team have many years of previous experience with rodent micronucleus studies.
| Test species and strain | Wistar Han rat |
| OECD guideline | 474 |
| Dosing regime | 2 doses, 24 hours apart |
| Scoring | Bone marrow (slide scored) |
| Formulation Analysis & Proof of Exposure | Available upon request |
| Endpoint | In vivo structural and nummercial chromosomal damage |