Ultrasensitive Saliva-Based Detection of Early Alzheimer’s Disease Biomarkers via Nanoparticle-Enhanced Evanescent Scattering Microscopy

Authors

Caterina Dallari 1 2, Georg Ladurner 3, Milana Kendrisic 3, Federica Fenizi Caria 1, Claudia Manzl 4, Luisa Ponticelli 1, Laura Perego 1, Francesco Goretti 1, Caterina Credi 1 2, Manuela Prokesch 5, Adelheid Wöhrer 3, Bernhard Baumann 3 6, Rainer Leitgeb 3, Francesco Saverio Pavone 1 2 7

Affiliations

1 European Laboratory for Non-Linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino 50019, Italy.
2 National Institute of Optics, National Research Council (INO-CNR), Sesto Fiorentino 50019, Italy.
3 Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna 1090, Austria.
4 Institute for Neuropathology and Molecular Neuropathology, Medical University of Innsbruck, Innsbruck 6020, Austria.
5 Scantox Neuro GmbH, Grambach 8074, Austria.
6 Institute of Biomedical Physics, Medical University of Innsbruck, Innsbruck 6020, Austria.
7 Department of Physics, University of Florence, Sesto Fiorentino 50019, Italy.

General info

  • Year: 2026
  • Division: Discovery
  • Disease: Alzheimer's disease
  • Model: 5xFAD mice
  • Material: Publication
  • DOI: 10.1021/acssensors.5c04842
  • Keywords: evanescent wave; gold nanoparticles; saliva-based assay; total internal reflection scattering (TIRS); ultrasensitive detection.