Longitudinal progression of blood biomarkers reveals a key role of reactive astrocytosis in preclinical Alzheimer’s disease

¹ Clinical and Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA
² Brain Aging and Behavior Section, Laboratory of Behavioral Neuroscience, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA
³ Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
⁴ Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
⁵ Scantox Neuro GmbH, Parkring 12, Grambach 8074, Austria
⁶ Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
⁷ Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
⁸ Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK
⁹ UK Dementia Research Institute at UCL, London, UK
¹⁰ Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China
¹¹ Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA
¹² Banner Alzheimer’s Institute and University of Arizona, Pheonix, AZ, USA
¹³ Banner Sun Health Research Institute, Sun City, AZ, USA
¹⁴ Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA