Home / Longitudinal investigation of spatial memory and retinal parameters in a 5xFAD model of Alzheimer’s disease reveals differences dependent on genotype and sex

Longitudinal investigation of spatial memory and retinal parameters in a 5xFAD model of Alzheimer’s disease reveals differences dependent on genotype and sex

Authors

Georg Ladurner ¹; Conrad Merkle ¹; Sybren Worm ¹; Yash Patel ¹; Lucas May ¹; Laurenz Jauk ²; Magdalena Daurer ²; Manuela Prokesch ²; Gerhard Garhofer ³; Bernhard Baumann ^{1 4}

Affiliations

¹ Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Vienna, Austria
²Scantox Neuro GmbH, Grambach, Styria, Austria
³ Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Vienna, Austria
⁴ Institute of Biomedical Physics, Medical University of Innsbruck, Innsbruck, Tyrol, Austria

Access the publication

https://pubmed.ncbi.nlm.nih.gov/41532120/

General info

Year: 2025
Division: Discovery
Disease: Alzheimer's disease
Model: 5xFAD mice
Material: Publication
DOI: 10.1364/BOE.579020
Keywords: Retina; Alzheimer’s disease; 5xFAD mouse model; Optical coherence tomography; Retinal thickness; Amyloid beta; Spatial memory; Transgenic mice; Retinal phenotype