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Scientific References – Publications

Scantox encourages its scientists to publish and disseminate the results of their high quality research which is mostly done in close collaboration with our clients.

TitleYearScantox Business UnitDiseaseModelKeywordsAuthorsAffiliationsDOIMore detailshf:tax:divisionhf:tax:diseasehf:tax:model
Intra-abdominal Abscesses in Two Göttingen Minipigs2024abscess; background; granuloma; minipig; safety; toxicology

Nanna Grand1, Gitte Jeppesen1, Abraham Nyska2

1 Scantox A/S, Denmark   2 Tel Aviv University, Tel Aviv, Israel

10.1177/01926233241289112journals.sagepub.com/doi/10.1177/01926233241289112regulatory-toxicologygottingen-minipig
Motor deficits and brain pathology in the Parkinson’s disease mouse model hA53Ttg2024

Livia Breznik, Magdalena Daurer, Roland Rabl, Tina Loeffler, Estibaliz Etxeberria-Rekalde, Joerg Neddens, Stefanie Flunkert, Manuela Prokesch

Scantox Neuro GmbH, Grambach, Austria

10.3389/fnins.2024.1462041www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1462041/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLEdiscoverypdalpha-synuclein-mouse-models
The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease2011

Annamaria Lanzillotta1, Ilenia Sarnico1, Marina Benarese1, Caterina Branca1, Cristina Baiguera1, Birgit Hutter-Paier2, Manfred Windisch2, Pierfranco Spano1,3, Bruno Pietro Imbimbo4, Marina Pizzi1,5

1 Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia and Istituto Nazionale di Neuroscienze Brescia, Brescia, Italy
2 JSW Life Sciences GmbH, Grambach, Austria
3 Istituto Ricovero e Cura a Carattere Scientifico, S. Camillo Hospital, Venice, Italy
4 Research and Development, Chiesi Farmaceutici, Parma, Italy
5 Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Viale Europa, 11, 25123, Brescia, Italy

10.1007/s12031-010-9482-2link.springer.com/article/10.1007/s12031-010-9482-2discoveryadappsl-mice
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers2011Alzheimer's disease, Cerebrospinal fluid, Biomarkers, External assurance, External control, Proficiency testing

Alzheimer’s Association QC Program Work Group (JSW Lifesciences GmbH collaborator: Duller S., Windisch M.)

Alzheimer’s Association QC Program Work Group

10.1016/j.jalz.2011.05.2243alz-journals.onlinelibrary.wiley.com/doi/10.1016/j.jalz.2011.05.2243discoveryadhuman
Comparison of pharmacological modulation of APP metabolism in primary chicken telencephalic neurons and in a human neuroglioma cell line2011,

Stefan Czvitkovich1, Stephan Duller1, Else Mathiesen1, Klaus Lorenzoni1, Bruno P Imbimbo2, Birgit Hutter-Paier1, Manfred Windisch1, Robert Wronski1

1 JSW Lifesciences GmbH, Parkring 12, 8074, Grambach, Austria
2 Research and Development, Chiesi-Farmaceutici S.p.A., Via Palermo, 26/A, 43100, Parma, Italy

10.1007/s12031-010-9416-zlink.springer.com/article/10.1007/s12031-010-9416-zdiscoveryadcell-line other
A longitudinal study of behavioral deficits in an AβPP transgenic mouse model of Alzheimer's disease2011Alzheimer's disease, amyloid-β, amyloid-β protein precursor, hole board task, memory, motor coordination, rodent, transgenic, water maze

Daniel Havas1, Birgit Hutter-Paier1, Kiren Ubhi2, Edward Rockenstein2, Karl Crailsheim4, Eliezer Masliah2,3, Manfred Windisch1

1 JSW LIFESCIENCES, Grambach, Austria
2 Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA
3 Department of Pathology, University of California, San Diego, La Jolla, CA, USA
4 Department of Zoology, Karl Franzens-University, Graz, Austria

10.3233/JAD-2011-101866content.iospress.com/articles/journal-of-alzheimers-disease/jad101866discoveryadappsl-mice
Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease2011

Randall J Bateman1, Paul S Aisen2, Bart De Strooper3,4, Nick C Fox5, Cynthia A Lemere6, John M Ringman7, Stephen Salloway8,9, Reisa A Sperling10, Manfred Windisch11, and Chengjie Xiong12,

1 ,Department of Neurology, Washington University School of Medicine, 660 S. Euclid, Campus Box 8111, St Louis, MO 63110, USA
2 ,Department of Neurosciences, University of California San Diego, Gilman Drive, La Jolla, CA 92093, USA
3 ,Department for Molecular and Developmental Genetics, Flanders Institute for Biotechnology (VIB), Leuven, Belgium
4 ,Center for Human Genetics, K.U. Leuven, Herestraat 49, 3000 Leuven, Belgium
5 ,Dementia Research Centre, UCL Institute of Neurology, University College London, London WC1N 3BG, UK
6 ,Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
7 ,Mary S. Easton Center for Alzheimer’s Disease Research, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
8 ,Department of Neurology, Memory and Aging Program, Butler Hospital, 345 Blackstone Boulevard, Providence, Rhode Island 02906-4800, USA
9 ,Department of Clinical Neurosciences and Psychiatry, Brown Medical School, USA
10 ,Center for Alzheimer Research and Treatment, Brigham and Women’s Hospital, Alzheimer’s Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
11 ,JSW LifeSciences GmbH, Parkring 12, A-8074 Grambach, Austria
12 ,Division of Biostatistics, Washington University, St Louis, MO 63110, USA

10.1186/alzrt59www.ncbi.nlm.nih.gov/pmc/articles/PMC3109410/discoveryad
Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice2012γ-secretase, Modulation, NSAID, Cognition, Amyloid, Alzheimer’s disease

Kathryn Rogers1,8, Kevin M Felsenstein1,9, Lori Hrdlicka1, Zhiming Tu1, Faris Albayya1, Winnie Lee1,10, Sarah Hopp,1,11, Mary-Jo Miller1,12, Darcie Spaulding1, Zhiyong Yang1,13, Hilliary Hodgdon1, Scott Nolan1, Melody Wen1, Don Costa1, Jean-Francois Blain1, Emily Freeman1, Bart De Strooper2,3, Veerle Vulsteke2,3, Louise Scrocchi4,14, Henrik Zetterberg5,6, Erik Portelius5, Birgit Hutter-Paier7, Daniel Havas7, Michael Ahlijanian1,15, Dorothy Flood1, Liza Leventhal1, Gideon Shapiro1,16, Holger Patzke1, Richard Chesworth1,17, and Gerhard Koenig1

1 ,EnVivo Pharmaceuticals, Inc, 500 Arsenal Street, Watertown, MA, 02472, USA
2 ,VIB Center for The Biology of Disease, Herestraat 49, Box 602, Leuven, 3000, Belgium
3 ,KULeuven and University Hospitals, Center for Human Genetics and LIND, Leuven, 3000, Belgium
4 ,Amorfix Life Sciences, 3403 American Drive, Mississauga, Ontario, L4V 1T4, Canada
5 ,Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, S-43180, Sweden
6 ,UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
7 ,QPS Austria GmbH, Parkring 12, Grambach, A-8074, Austria
8 ,Present address: CoMentis Research Facility, 865 Research Parkway, Suite 400, Oklahoma City, OK, 73104, USA
9 ,Present address: Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, 1275 Center Drive, BMS J-484, Gainesville, FL 32610, USA
10 ,Present address: Eisai, Inc., 4 Corporate Dr, Andover, MA, 01810, USA
11 ,Present address: Neuroscience Department, The Ohio State University, Columbus, OH, 43210, USA
12 ,Present address: Galenea, 300 Technology Square # 2, Cambridge, MA, 02139, USA
13 ,Present address: University of Maryland Baltimore, 650 West Baltimore St., Room 7211, Baltimore, MD, 21201, USA
14 ,Present address: Biopharmaceuticals, Apotex, Inc, 150 Signet Drive, Toronto, Ontario, M9L 1T9, Canada
15 ,Present address: Neuroscience Biology, Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT, 06492, USA
16 ,Present address: Pharmore, Inc, 5507 NW 80th Ave, Gainesville, FL, 32653, USA
17 ,Present address: Epizyme, Inc, 325 Vassar Street, Suite 2B, Cambridge, MA, 02139, USA

10.1186/1750-1326-7-61www.ncbi.nlm.nih.gov/pmc/articles/PMC3573960/discoveryadother
Elevated Levels of Soluble Total and Hyperphosphorylated Tau Result in Early Behavioral Deficits and Distinct Changes in Brain Pathology in a New Tau Transgenic Mouse Model2012, Memory deficits, Phosphorylation, Tau, Tauopathy, Transgenic mouse model

S. Flunkert1, M. Hierzer1, T. Löffler1, R. Rabl1, J. Neddens1, S. Duller1, E.L. Schofield;2, M.A. Ward2, M. Posch1, H. Jungwirth3, M. Windisch1, B. Hutter-Paier1,

1 JSW Life-Sciences GmbH, Grambach, Austria
2 Proteome Sciences plc., London, UK
3 Karl Franzens University, Graz, Austria

10.1159/000338152karger.com/ndd/article-abstract/11/4/194/205482/Elevated-Levels-of-Soluble-Total-and?redirectedFrom=fulltextdiscoveryad tauopathiesother
Stable Mutated tau441 Transfected SH-SY5Y Cells as Screening Tool for Alzheimer’s Disease Drug Candidates2012Tau, Hyperphosphorylation, Kinase inhibitor, Drug development

Tina Löffler1, Stefanie Flunkert1, Nicole Taub1, Emma L. Schofield2, Malcolm A. Ward2, Manfred Windisch1, and Birgit Hutter-Paier1

1 JSW Life Sciences GmbH, Parkring 12, 8074 Grambach, Austria
2 Proteome Sciences plc, London, UK

10.1007/s12031-012-9716-6www.ncbi.nlm.nih.gov/pmc/articles/PMC3323815/discoveryadcell-line
Prion-Like Behavior and Tau-dependent Cytotoxicity of Pyroglutamylated β-Amyloid2012

Justin M. Nussbaum1, Stephan Schilling4, Holger Cynis4, Antonia Silva1, Eric Swanson1, Tanaporn Wangsanut1, Kaycie Tayler3, Brian Wiltgen3, Asa Hatami5, Raik Rönicke6, Klaus Reymann6, Birgit Hutter-Paier7, Anca Alexandru8, Wolfgang Jagla8, Sigrid Graubner8, Charles G. Glabe5, Hans-Ulrich Demuth4,8, and George S. Bloom1,2

1 Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
2 Department of Cell Biology, University of Virginia, Charlottesville, VA 22904, USA
3 Department of Psychology, University of Virginia, Charlottesville, VA 22904, USA
4 Probiodrug AG, 06120 Halle (Saale), Germany
5 Department of Biochemistry and Molecular Biology, University of California at Irvine, Irvine CA 92697, USA
6 Deutsches Zentrum fuer Neurodegenerative Erkrankungen, c/o Leibniz-Institut fuer Neuro-biologie, 39118 Magdeburg, Germany
7 JSW Life Sciences GmbH, A-8074 Grambach, Austria
8 Ingenium Pharmaceuticals GmbH, 82152 Munich-Martinsried, Germany

10.1038/nature11060www.ncbi.nlm.nih.gov/pmc/articles/PMC3367389/discoveryadappslxhqc
Increased efflux of amyloid-β peptides through the blood-brain barrier by muscarinic acetylcholine receptor inhibition reduces pathological phenotypes in mouse models of brain amyloidosis2014, Aβ brain efflux, Aβ clearance, Aβ homeostasis, AβPP transgenic mice, amyloid-β peptides, drug treatment, muscarinic receptors, plaque deposition

Paolo Paganetti1, Katia Antoniello1, Kavi Devraj2, Nicolas Toni1, Dairin Kieran1, Rime Madani1, Maria Pihlgren1, Oskar Adolfsson1, Wolfgang Froestl1, André Schrattenholz3, Stefan Liebner2, Daniel Havas4, Manfred Windisch4, John R Cirrito5, Andrea Pfeifer1, Andreas Muhs1

1 AC Immune SA, Lausanne, Switzerland
2 Institute of Neurology, Medical School Goethe University, Frankfurt am Main, Germany
3 ProteoSys AG, Mainz, Germany
4 QPS Austria, Grambach, Austria
5 Department of Neurology, Knight AD Research Center, and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

10.3233/JAD-131091content.iospress.com/articles/journal-of-alzheimers-disease/jad131091discoveryadapp-ps1-mice appsl-mice
The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon2013Alzheimer’s disease; NMDA receptors; acetylcholinesterase; amyloid aggregation; butyrylcholinesterase; dual binding inhibitors.

Michela Rosini1, Elena Simoni1, Manuela Bartolini1, Elena Soriano2, José Marco-Contelles2, Vincenza Andrisano3, Barbara Monti1, Manfred Windisch4, Birgit Hutter-Paier4, David W McClymont5, Ian R Mellor5, Maria Laura Bolognesi1

1 Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
2 Instituto de Quimica Organica General (CSIC), Juan de la Cierva, 3, 28006 Madrid, Spain
3 Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Rimini Campus, Italy
4 JSW Lifesciences GmbH, Parkring 12, 8074 Grambach, Austria
5 School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK

10.1002/cmdc.201300263chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.201300263discoveryadother
Commentary to the recently published review "Drug pipeline in neurodegeneration based on transgenic mice models of Alzheimer's disease" by Li, Evrahimi and Schluesener. Ageing Res. Rev. 2013 Jan;12(1):116-402013, APP; Alzheimer's disease; Animal models; Drug trials; Tau.

M Windisch1, S Flunkert1, D Havas1, B Hutter-Paier1

1 QPS Austria GmbH, Parkring 12, 8074 Grambach, Austria.

10.1016/j.arr.2013.06.006www.sciencedirect.com/science/article/abs/pii/S1568163713000500?via%3Dihubdiscoveryadappsl-mice htau-mice
CSF biomarker variability in the Alzheimer's Association quality control program2013Alzheimer's disease, Cerebrospinal fluid, Biomarkers, External assurance, Quality control, Proficiency testing

Alzheimer’s Association QC Program Work Group (QPS Austria GmbH collaborator: Duller S.)

Alzheimer’s Association QC Program Work Group

10.1016/j.jalz.2013.01.010alz-journals.onlinelibrary.wiley.com/doi/10.1016/j.jalz.2013.01.010discoveryadhuman
Impact of ApoB-100 expression on cognition and brain pathology in wild-type and hAPPsl mice2013Alzheimer's disease; Apolipoprotein B-100; Brain; Hyperlipidemia; Transgenic mice; Vascular risk factor.

Tina Löffler1,2, Stefanie Flunkert1, Daniel Havas1, Miklós Sántha3, Birgit Hutter-Paier1, Ernst Steyrer2, Manfred Windisch1

1 QPS Austria, Grambach, Austria
2 Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria
3 Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary

10.1016/j.neurobiolaging.2013.04.008www.sciencedirect.com/science/article/abs/pii/S0197458013001619?via%3Dihubdiscoveryadappsl-mice
Non-selective calcium channel blocker bepridil decreases secondary pathology in mice after photothrombotic cortical lesion2013Thalamus, Genetically modified animals, Mouse models, Rodents, Calcium antagonist therapy, Calcium channels, Drug therapy, Alzheimer's disease

Anu Lipsanen1, Stefanie Flunkert2, Kristina Kuptsova1, Mikko Hiltunen1, Manfred Windisch2, Birgit Hutter-Paier2, Jukka Jolkkonen1

1 Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland
2 QPS Austria GmbH, Grambach, Austria

10.1371/journal.pone.0060235journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0060235discoveryadappsl-mice
CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-β plaques in an Alzheimer's disease mouse model2013Alzheimer's disease, amyloid-β, astrocytes, L-type Ca2+ channel

Nina Daschil1, Gerald J Obermair2, Bernhard E Flucher2, Nadia Stefanova3, Birgit Hutter-Paier4, Manfred Windisch4, Christian Humpel1, Josef Marksteiner5

1 Department of Psychiatry and Psychotherapy, University Clinic of General and Social Psychiatry, Innsbruck Medical University, Innsbruck, Austria
2 Division of Physiology, Innsbruck Medical University, Innsbruck, Austria
3 Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
4 QPS-Austria GmbH, Grambach, Austria
5 Department of Psychiatry and Psychotherapy A, General Hospital LKH Hall, Milserstrasse, Austria

10.3233/JAD-130560content.iospress.com/articles/journal-of-alzheimers-disease/jad130560discoveryadappsl-mice
In vivo and ex vivo imaging of amyloid-β cascade aggregates with a Pronucleon™ peptide2013Alzheimer's disease, amyloid-β peptide, amyloid-β protein, imaging, oligomer, plaques, senile plaques

Andrew C Nyborg1, Jonathan R Moll1, Renee D Wegrzyn1, Daniel Havas2, Birgit Hutter-Paier2, Giora G Z Feuerstein1, Alan S Rudolph1

1 Adlyfe Inc., Rockville, MD, USA
2 JSW Life Sciences GmbH, Grambach, Austria

10.3233/JAD-122107content.iospress.com/articles/journal-of-alzheimers-disease/jad122107discoveryadappsl-mice
Time course and progression of wild type α-Synuclein accumulation in a transgenic mouse model2013Behavior, Immunofluorescence, Motor deficit, Mouse model, Parkinson’s disease, Phosphorylation, Synucleinopathy, α-Synuclein, Transgene

David Amschl1, Jörg Neddens1, Daniel Havas1, Stefanie Flunkert1, Roland Rabl1, Heinrich Römer2, Edward Rockenstein3, Eliezer Masliah3, Manfred Windisch1 and Birgit Hutter-Paier1

1 QPS Austria GmbH, Parkring 12, Grambach, 8074, Austria
2 Karl Franzens University, Institute of Zoology, Graz, 8010, Austria
3 Department of Pathology, University of California San Diego, La Jolla, CA, USA

10.1186/1471-2202-14-6www.ncbi.nlm.nih.gov/pmc/articles/PMC3546911/discoverypdd-line-mice
Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits2014Oligomers, Monomers, Membrane trafficking, Neurons, Alzheimer's disease, Cell binding, Small molecules, Binding analysis

Nicholas J Izzo1, Agnes Staniszewski2, Lillian To 3, Mauro Fa2, Andrew F Teich2, Faisal Saeed2, Harrison Wostein1, Thomas Walko 3rd 1, Anisha Vaswani1, Meghan Wardius1, Zanobia Syed1, Jessica Ravenscroft1, Kelsie Mozzoni1, Colleen Silky1, Courtney Rehak1, Raymond Yurko1, Patricia Finn1, Gary Look1, Gilbert Rishton1, Hank Safferstein1, Miles Miller4, Conrad Johanson4, Edward Stopa4, Manfred Windisch5, Birgit Hutter-Paier6, Mehrdad Shamloo3, Ottavio Arancio2, Harry LeVine 3rd7, Susan M Catalano1

1 Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
2 Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America.
3 Stanford University Medical School Behavioral and Functional Neuroscience Laboratory, Palo Alto, California, United States of America.
4 Department of Pathology and Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America.
5 NeuroScios, GmbH, Graz, Austria.
6 QPS Austria GmbH, Grambach, Austria.
7 Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America.

10.1371/journal.pone.0111898journals.plos.org/plosone/article?id=10.1371/journal.pone.0111898discoveryadcell-line
Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivomodel of Alzheimer’s disease2014

Tina Löffler1, Stefanie Flunkert1, Daniel Havas1, Cornelia Schweinzer1, Marni Uger2, Manfred Windisch1, Ernst Steyrer3, Birgit Hutter-Paier1

1 QPS-Austria GmbH, Parkring 12, 8074 Grambach, Austria.
2 Amorfix Life Sciences Ltd, 3403 American Drive, Ontario, L4V 1 T4, Canada
3 Institute of Molecular Biology and Biochemistry, Medical University Graz, Harrachgasse 21, 8010, Graz, Austria

10.1186/1742-2094-11-84jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-11-84discoveryadappsl-mice
Tracking of Magnetite Labeled Nanoparticles in the Rat Brain Using MRI2014Magnetite, Nanoparticles, Magnetic resonance imaging, NMR relaxation, Fluorescence imaging, Prussian blue staining, Central nervous system, Body temperature

Naira P. Martínez Vera1, Reinhold Schmidt1, Klaus Langer2, Iavor Zlatev2, Robert Wronski3, Ewald Auer3, Daniel Havas3, Manfred Windisch3, Hagen von Briesen4, Sylvia Wagner4, Julia Stab4, Motti Deutsch5, Claus Pietrzik6, Franz Fazekas1, Stefan Ropele1

1 Department of Neurology, Medical University of Graz, Graz, Austria
2 Institute of Pharmaceutical Technology and Biopharmacy, University of Muenster, Muenster, Germany
3 JSW-Live Sciences GmbH, Grambach, Austria
4 Department of Cell Biology & Applied Virology, Fraunhofer Institute for Biomedical Engineering, St. Ingbert, Germany
5 Physics Department, Schottenstein Center for the Research and Technology of the Cellome, Bar Ilan University, Ramat Gan, Israel
6 Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany

10.1371/journal.pone.0092068journals.plos.org/plosone/article?id=10.1371/journal.pone.0092068discoveryn-arats
Late-stage α-synuclein accumulation in TNWT-61 mouse model of Parkinson's disease detected by diffusion kurtosis imaging2015Parkinson's disease; TBSS; TNWT-61; diffusion kurtosis imaging; mean kurtosis; transgenic mice; α-syn.

Amit Khairnar1, Jana Ruda-Kucerova2,3, Eva Drazanova3,4, Nikoletta Szabó5, Peter Latta6, Anas Arab3, Birgit Hutter-Paier7, Daniel Havas7, Manfred Windisch8, Alexandra Sulcova2, Zenon Starcuk Jr4,6, András Király5,6, Irena Rektorova1

1 Applied Neuroscience Research Group, CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
2 Experimental and Applied Neuropsychopharmacology Group, CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
3 Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
4 Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic.
5 Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary.
6 Multimodal and Functional Imaging Laboratory, CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
7 QPS Austria GmbH, Grambach, Austria.
8 NeuroScios GmbH, Graz, Austria.

10.1111/jnc.13500onlinelibrary.wiley.com/doi/epdf/10.1111/jnc.13500discoverypdline-61-mice
Diffusion Kurtosis Imaging Detects Microstructural Alterations in Brain of α-Synuclein Overexpressing Transgenic Mouse Model of Parkinson's Disease: A Pilot Study2015Diffusion kurtosis imaging; Parkinson’s disease; TBSS; TNWT-61; Transgenic mice; α-Synuclein.

Amit Khairnar1, Peter Latta2, Eva Drazanova3,4, Jana Ruda-Kucerova4,5, Nikoletta Szabó6, Anas Arab4,5, Birgit Hutter-Paier7, Daniel Havas7, Manfred Windisch8, Alexandra Sulcova5, Zenon Starcuk Jr2,3, Irena Rektorova1

1 Applied Neuroscience Research Group, CEITEC – Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
2 Multimodal and Functional Imaging Laboratory, CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
3 Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic.
4 Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
5 Experimental and Applied Neuropsychopharmacology Group, CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
6 Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary.
7 QPS Austria GmbH, Grambach, Austria.
8 NeuroScios GmbH, Graz, Austria.

10.1007/s12640-015-9537-9link.springer.com/article/10.1007/s12640-015-9537-9discoverypdline-61-mice
Long-term treatment of aged Long Evans rats with a dietary supplement containing neuroprotective peptides (N-PEP-12) to prevent brain aging: effects of three months daily treatment by oral gavage2015N-PEP-12; brain aging; hippocampus; oral gavage.

B Hutter-Paier1, B Reininger-Gutmann2, R Wronski1, E Doppler3, H Moessler3

1 QPS Austria, Grambach, Austria.
2 Medizinische Universität Graz, Graz, Austria.
3 EVER Neuro Pharma GmbH, Unterach, Austria.

www.ncbi.nlm.nih.gov/pmc/articles/PMC4392105/discoveryotherrats
Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound2015disease-modifying anti-Alzheimer drugs; multitarget drugs; neuroprotection; animal models of Alzheimer’s disease; multigram preparative chromatographic resolution

Irene Sola1, Elisabet Viayna1, Tània Gómez1, Carles Galdeano1, Matteo Cassina1, Pelayo Camps1, Margherita Romeo2, Luisa Diomede2, Mario Salmona2, Pilar Franco3, Mireille Schaeffer3, Diego Colantuono3, David Robin3, Daniela Brunner4, Nicole Taub4, Birgit Hutter-Paier4, Diego Muñoz-Torrero1

1 Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, Barcelona E-08028, Spain.
2 Department of Molecular Biochemistry and Pharmacology, IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri”, Via La Masa 19, Milan 20156, Italy.
3 Chiral Technologies Europe, Parc d’Innovation, Bd. Gonthier d’Andernach, Illkirch F-67400, France.
4 Neuropharmacology Department of QPS Austria-Gmbh, Parkring 12, Grambach 8074, Austria.

10.3390/molecules20034492www.mdpi.com/1420-3049/20/3/4492discoveryadappsl-mice
L-type calcium channel blockers and substance P induce angiogenesis of cortical vessels associated with beta-amyloid plaques in an Alzheimer mouse model2015Alzheimer; Angiogenesis; Beta-amyloid plaque; L-type calcium channel; Reactive astrocytes; Substance P; Vessels.

Nina Daschil1, Kathrin M Kniewallner1, Gerald J Obermair2, Birgit Hutter-Paier3, Manfred Windisch4, Josef Marksteiner5, Christian Humpel1

1 Department of Psychiatry and Psychotherapy, University Clinic of General and Social Psychiatry, Medical University of Innsbruck, Innsbruck, Austria.
2 Department of Physiology and Medical Physics, Medical University of Innsbruck, Innsbruck, Austria.
3 QPS Austria GmbH, Grambach, Austria.
4 NeuroScios GmbH, Graz, Austria.
5 Department of Psychiatry and Psychotherapy A, General Hospital LKH Hall, Hall, Austria.

10.1016/j.neurobiolaging.2014.12.027www.sciencedirect.com/science/article/pii/S0197458014008446?via%3Dihubdiscoveryadappsl-mice
Influence of Lentiviral β-Synuclein Overexpression in the Hippocampus of a Transgenic Mouse Model of Alzheimer's Disease on Amyloid Precursor Protein Metabolism and Pathology2015β-Synuclein, Alzheimer's disease, Amyloid precursor protein, Protein aggregation, AKT signaling, Glycogen synthase kinase 3 beta, Transgenic mice

Stefanie Krassnig1,2, Cornelia Schweinzer2, Nicole Taub2, Daniel Havas2, Ewald Auer2, Stefanie Flunkert2, Wolfgang Schreibmayer1, Birgit Hutter-Paier2, Manfred Windisch2

1 Institute of Biophysics, Medical University Graz, Graz, Austria.
2QPS Austria, Neuropharmacology, Grambach, Austria

10.1159/000430952karger.com/ndd/article-abstract/15/4/243/205559/Influence-of-Lentiviral-Synuclein-Overexpression?redirectedFrom=fulltextdiscoveryadappsl-mice
Quantitative evaluation of orofacial motor function in mice: The pasta gnawing test, a voluntary and stress-free behavior test2016Amyotrophic lateral sclerosis; Neurodegenerative disease; Niemann-Pick disease; Parkinson’s disease; TDP-43; α-synuclein

R Rabl1, A Horvath1, C Breitschaedel1,2, S Flunkert1, H Roemer2, B Hutter-Paier1

1 QPS Austria GmbH, Neuropharmacology, Parkring 12, 8074 Grambach, Austria.
2 Karl Franzens University, Institute of Zoology, Universitätsplatz 2, 8010 Graz, Austria.

10.1016/j.jneumeth.2016.10.006www.sciencedirect.com/science/article/pii/S0165027016302308?via%3Dihubdiscoveryn-amice
Brain cortical cholesterol metabolism is highly affected by human APP overexpression in mice2016APP(SL); Alzheimer's disease; Amyloid precursor protein overexpression; Aβ; Cholesterol; Mouse model.

Tina Löffler1, Cornelia Schweinzer1, Stefanie Flunkert1, Miklós Sántha2, Manfred Windisch3, Ernst Steyrer4, Birgit Hutter-Paier1

1 QPS Austria, Parkring 12, 8074 Grambach, Austria.
2 Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Temesvári krt. 62, 6726 Szeged, Hungary.
3 NeuroScios GmbH, Willersdorferstrasse 6, 8061 St. Radegund, Austria.
4 Institute of Molecular Biology and Biochemistry, Medical University Graz, Harrachgasse 21, 8010 Graz, Austria.

10.1016/j.mcn.2016.03.004www.sciencedirect.com/science/article/abs/pii/S1044743116300197?via%3Dihubdiscoveryadappsl-mice
Decreased Plasma Aβ in Hyperlipidemic APPSL Transgenic Mice Is Associated with BBB Dysfunction2016APP mice; Alzheimer's disease; blood brain barrier (BBB); cerebrovascular disorders; cholesterol; high-fat diet; plasma Aβ.

Tina Löffler1, Stefanie Flunkert1, Magdalena Temmel1, Birgit Hutter-Paier1

1 Neuropharmacology, QPS Austria Grambach, Austria.

10.3389/fnins.2016.00232www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2016.00232/fulldiscoveryadappsl-mice
Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer's Disease2017d-enantiomeric peptides; Alzheimer’s disease; Aβ oligomers; amyloid β; cognition; large-scale; oral treatment; transgenic mice

Janine Kutzsche1, Sarah Schemmert1, Markus Tusche1, Jörg Neddens2, Roland Rabl2, Dagmar Jürgens1, Oleksandr Brener3, Antje Willuweit1,4, , Birgit Hutter-Paier2, Dieter Willbold1,4

1 Institute of Complex Systems, Structural Biochemistry (ICS-6), Forschungszentrum Jülich, Jülich 52425, Germany.
2 QPS Austria GmbH, Grambach A-8074, Austria.
3 Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf 40225, Germany.
4 Institute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, Jülich 52425, Germany.

10.3390/molecules22101693www.mdpi.com/1420-3049/22/10/1693discoveryadappsl-mice
SEN1500, a novel oral amyloid-β aggregation inhibitor, attenuates brain pathology in a mouse model of Alzheimer's disease2017Activated microglia; Aggregation inhibitor; Amyloid-β; Pharmacotherapy; Plaques; SEN1500

D Brunner1, S Flunkert1, J Neddens1, S Duller1, D I C Scopes2, J M Treherne2, B Hutter-Paier1

1 QPS Austria GmbH, Parkring 12, 8074 Grambach, Austria.
2 Senexis Limited, Babraham Research Campus, Cambridge CB22 3AT, UK.

10.1016/j.neulet.2017.09.028www.sciencedirect.com/science/article/abs/pii/S030439401730770X?via%3Dihubdiscoveryadappsl-mice
Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form2017Alpha-synuclein; Antidepressants; Biophysics; Nortriptyline; Parkinson's disease; Pre-formed fibrils; Transgenic Drosophila; Transgenic mouse

Timothy J Collier1, Kinshuk R Srivastava2, Craig Justman3, Tom Grammatopoulous4, Birgit Hutter-Paier5, Manuela Prokesch5, Daniel Havas5, Jean-Christophe Rochet6, Fang Liu6, Kevin Jock2, Patrícia de Oliveira2, Georgia L Stirtz7, Ulf Dettmer7, Caryl E Sortwell8, Mel B Feany9, Peter Lansbury10, Lisa Lapidus2, Katrina L Paumier11

1 Department of Translational Science and Molecular Medicine, Michigan State University, Grand Rapids, MI, USA; Mercy Health Hauenstein Neuroscience Center, Grand Rapids, MI, USA.
2 Department of Physics and Astronomy, Michigan State University, East Lansing, MI, USA.
3 Lysosomal Therapeutics, Inc., Cambridge, MA, USA.
4 BioEnergetics, Boston, MA, USA.
5 QPS Research, Graz, Austria.
6 Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
7 Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.
8 Department of Translational Science and Molecular Medicine, Michigan State University, Grand Rapids, MI, USA; Mercy Health Hauenstein Neuroscience Center, Grand Rapids, MI, USA.
9 Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA.
10 Lysosomal Therapeutics, Inc., Cambridge, MA, USA; Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.
11 Department of Neurology, Washington University, Saint Louis, MO, USA.

10.1016/j.nbd.2017.07.007www.sciencedirect.com/science/article/abs/pii/S0969996117301596?via%3Dihubdiscoverypdother
Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer's Disease-Studies on Relation to Effective Target Occupancy2017

Torsten Hoffmann1, Antje Meyer1, Ulrich Heiser1, Stephan Kurat2, Livia Böhme1, Martin Kleinschmidt3, Karl-Ulrich Bühring1, Birgit Hutter-Paier2, Martina Farcher2, Hans-Ulrich Demuth3, Inge Lues1, Stephan Schilling3

1 Probiodrug AG, Halle, Germany
2 QPS Austria, Grambach, Austria
3 Fraunhofer Institute for Cell Therapy and Immunology, Department for Drug Design and Target Validation, Halle, Germany

10.1124/jpet.117.240614jpet.aspetjournals.org/content/362/1/119.longdiscoveryadappslxhqc
Early and progressive microstructural brain changes in mice overexpressing human α-Synuclein detected by diffusion kurtosis imaging2017

Khairnar A1, Ruda-Kucerova J2, Szabó N3, Drazanova E2,4, Arab A2, Hutter-Paier B5, Neddens J5, Latta P6, Starcuk Z Jr4,6, Rektorova I1.

1 Applied Neuroscience Research Group, CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic
2 Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
3 Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary
4 Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic
5QPS Austria GmbH, Grambach, Austria
6Multimodal and Functional Imaging Laboratory, CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic

10.1016/j.bbi.2016.11.027www.sciencedirect.com/science/article/abs/pii/S0889159116305293discoverypdline-61-mice
Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice2017Memory deficits; Motor deficits; Parkinson’s disease; Protein expression; Synucleinopathies; α-Synuclein.

R Rabl1, C Breitschaedel1,2, S Flunkert1, S Duller1, D Amschl1, J Neddens1, V Niederkofler1, E Rockenstein3, E Masliah3, H Roemer 2, B Hutter-Paier1

1 QPS Austria GmbH, Parkring 12, 8074, Grambach, Austria.
2 Institute of Zoology, Karl Franzens University, Graz, Austria.
3 Department of Pathology, University of California San Diego, La Jolla, CA, USA.

10.1186/s12868-017-0341-8bmcneurosci.biomedcentral.com/articles/10.1186/s12868-017-0341-8discoverypdline-61-mice
BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains2018Neurons, Mouse models, Hippocampus, Cerebellum, Alzheimer's disease, Proteolysis, Cholesterol, Actins

Mirsada Causevic1, Kristina Dominko1, Martina Malnar1, Lea Vidatic1, Stjepko Cermak1, Martina Pigoni2, Peer-Hendrik Kuhn3, Alessio Colombo2, Daniel Havas4, Stefanie Flunkert4, Jessica McDonald5, Jenny M Gunnersen6,7, Birgit Hutter-Paier4, Sabina Tahirovic2, Manfred Windisch4, Dimitri Krainc5, Stefan F Lichtenthaler2,8,9, Silva Hecimovic1

1Laboratory for Neurodegenerative Disease Research, Division of Molecular Medicine, Ruder Boskovic Institute, Zagreb, Croatia.
2 German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
3 Institut für Allgemeine Pathologie und pathologische Anatomie, Klinikum rechts der Isar der Technische Universität München and Institute for Advanced Study, Munich, Germany.
4 QPS Austria GmbH, Grambach, Austria.
5 The Ken and Ruth Davee Department of Neurology and Clinical Neurological Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
6 Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, Victoria, Australia.
7 The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
8 Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
9 Neuroproteomics, Klinikum rechts der Isar, and Institute for Advanced Study, Technische Universität München, Munich, Germany.

10.1371/journal.pone.0200344journals.plos.org/plosone/article?id=10.1371/journal.pone.0200344discoveryniemann-pick-diseasenpc1-mice
Phosphorylation of different tau sites during progression of Alzheimer's disease2018Cingulate; Frontal; Immunofluorescent labeling; Microtubule-associated protein tau; Occipital and temporal cortex; Phosphorylation; Transentorhinal region

Joerg Neddens1, Magdalena Temmel1, Stefanie Flunkert1, Bianca Kerschbaumer1,2, Christina Hoeller1,3, Tina Loeffler1, Vera Niederkofler1, Guenther Daum2, Johannes Attems4, Birgit Hutter-Paier1

1 QPS Austria GmbH, Neuropharmacology, Parkring 12, 8074, Grambach, Austria.
2 Institute for Biochemistry, Graz University of Technology, Graz, Austria.
3 Institute of Zoology, Karl Franzens University, Graz, Austria.
4 Institute of Neuroscience and Newcastle University Institute for Ageing Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.

10.1186/s40478-018-0557-6actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0557-6discoveryadhuman
mTh1 driven expression of hTDP-43 results in typical ALS/FTLD neuropathological symptoms2018Mouse models, Spinal cord, Mice, Genetically modified animals, Hippocampus, Animal behavior, Medulla oblongata, Amyotrophic lateral sclerosis

Barbara Scherz1,2, Roland Rabl1, Stefanie Flunkert1, Siegfried Rohler3, Joerg Neddens1, Nicole Taub1, Magdalena Temmel1, Ute Panzenboeck3, Vera Niederkofler1, Robert Zimmermann2, Birgit Hutter-Paier1

1 QPS Austria GmbH, Grambach, Austria
2 Karl-Franzens University, Institute of Molecular Biosciences, Graz, Austria
3 Medical University Graz, Institute of Pathophysiology and Immunology, Graz, Austria

10.1371/journal.pone.0197674journals.plos.org/plosone/article?id=10.1371/journal.pone.0197674discoveryalstar6-6-mice
Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans2019lipase; lysobisphosphatidic acid; lysosomal storage disorders; nonalcoholic fatty liver disease; obesity; phospholipids; α/β-hydrolase domain-containing 6.

Gernot F Grabner1, Nermeen Fawzy2, Maria A Pribasnig1, Markus Trieb3, Ulrike Taschler1, Michael Holzer3, Martina Schweiger1, Heimo Wolinski1, Dagmar Kolb4, Angela Horvath5, Rolf Breinbauer6, Thomas Rülicke7, Roland Rabl8, Achim Lass2, Vanessa Stadlbauer5, Birgit Hutter-Paier8, Rudolf E Stauber5, Peter Fickert5, Rudolf Zechner2, Gunther Marsche9, Thomas O Eichmann10, Robert Zimmermann11

1 Institute of Molecular Biosciences, University of Graz, Graz, Austria.
2 Institute of Molecular Biosciences, University of Graz, Graz, Austria; BioTechMed-Graz Graz, Austria.
3 Division of Pharmacology Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
4 Core Facility Ultrastructure Analysis Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
5 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
6 Institute of Organic Chemistry Graz University of Technology, Graz, Austria; BioTechMed-Graz Graz, Austria.
7 Institute of Laboratory Animal Science University of Veterinary Medicine Vienna, Vienna, Austria.
8 QPS Austria GmbH, Grambach, Austria.
9 Division of Pharmacology Otto Loewi Research Center, Medical University of Graz, Graz, Austria; BioTechMed-Graz Graz, Austria.
10 Institute of Molecular Biosciences, University of Graz, Graz, Austria; Center for Explorative Lipidomics Graz, Austria; BioTechMed-Graz Graz, Austria.
11 Institute of Molecular Biosciences, University of Graz, Graz, Austria; BioTechMed-Graz Graz, Austria.

10.1194/jlr.M093351www.jlr.org/article/S0022-2275(20)32271-9/fulltextdiscoveryothermice
Hepatic and neuronal phenotype of NPC1−/− mice2019Cell biology, Molecular biology, Neuroscience, Physiology

Estibaliz Santiago-Mujica1, Stefanie Flunkert1, Roland Rabl1, Joerg Neddens1, Tina Loeffler1, Birgit Hutter-Paier1

1 QPS Austria GmbH, Parkring 12, 8074, Grambach, Austria

10.1016/j.heliyon.2019.e01293www.sciencedirect.com/science/article/pii/S2405844018330287discoveryniemann-pick-diseasenpc1-mice
Correction: Further investigation of phenotypes and confounding factors of progressive ratio performance and feeding behavior in the BACHD rat model of Huntington disease.2019

Erik Karl Håkan Clemensson1, Laura Emily Clemensson1, Benedikt Fabry1, Stefanie Flunkert2, Olaf Riess, Robert Wronski2, Huu Phuc Nguyen1

1 Institute of Medical Genetics and Applied Genomics, Tuebingen, Tuebingen, Germany, Centre for Rare Diseases, Tuebingen, Tuebingen, Germany
2 QPS Austria, Grambach, Austria

10.1371/journal.pone.0213755www.ncbi.nlm.nih.gov/pmc/articles/PMC6405079/discoveryhdbachd-rats
Gadolinium Presence in Rat Skin: Assessment of Histopathologic Changes Associated with Small Fiber Neuropathy2024

Janina Boyken1, Jessica Lohrke1, Axel Treu3, Joerg Neddens5, Gregor Jost1, Hannes-Friedrich Ulbrich2, Thomas Balzer6, Thomas Frenzel1, Manuela Prokesch5, Uwe Thuss4, Hubertus Pietsch1

1 Department of MR and CT Contrast Media Research, Bayer, Müllerstraße 178, 13353 Berlin, Germany

2 Research and Pre-Clinical Statistics Group, Bayer, Müllerstraße 178, 13353 Berlin, Germany

3 Department of In Vivo/Radioanalytics, Bayer, Wuppertal, Germany

4 Department of Bioanalytics LC-MS 3 & MALDI, Bayer, Wuppertal, Germany

5 Department of Neuropharmacology, QPS Austria, Grambach, Austria

6 External Corporate Employment Resources, Bayer U.S., Whippany

10.1148/radiol.231984doi.org/10.1148/radiol.231984discoveryrats
Protective Non-neutralizing antiN-terminal Domain mAb Maintains Fc-mediated Function against SARS-COV-2 Variants up to BA.2.86-JN.1 with Superfluous In Vivo Protection against JN.1 Due to Attenuated Virulence2024Monoclonal Antibodies, ACE 2-receptor, K18 hACE2 Tg mice

Arman Izadi1, Magdalena Godzwon2,  Anna Söderlund Strand3, Tobias Schmidt4,5,
Susanna Kumlien Georén6, Christian Drosten7,8 , Mats Ohlin 2,9 and Pontus Nordenfelt1,3

1 Department of Clinical Sciences Lund, Division of Infection Medicine, Faculty of Medicine, Lund University, Lund, Sweden;
2 Department of Immunotechnology, Lund University, Lund, Sweden;
3 Department of Laboratory Medicine, Clinical Microbiology, Skåne University Hospital Lund, Lund University, Lund, Sweden;
4 Department of Clinical Sciences Lund, Division of Pediatrics, Faculty of Medicine, Lund University, Lund, Sweden;
5 Wallenberg Center for Molecular Medicine, Faculty of Medicine, Lund University, Lund, Sweden;
6 Scantox A/S, Stockholm, Sweden;
7 German Center for Infection Research, Berlin, Germany;
8 Institute of Virology, Charité-Universitätsmedizin Berlin, Berlin, Germany;
9  SciLifeLab Drug Discovery and Development, Lund University, Lund, Sweden

10.4049/jimmunol.2300675doi.org/10.4049/jimmunol.2300675discoverysars-covmice
Probing Skin Barrier Recovery on Molecular Level Following Acute Wounds: An In Vivo/Ex Vivo Study on Pigs2021

Enamul Haque Mojumdar 1,2, Lone Bruhn Madsen3, Henri Hansson4, Ida Taavoniku3, Klaus Kristensen3,
Christina Persson5, Anna Karin Morén4, Rajmund Mokso6, Artur Schmidtchen7, Tautgirdas Ruzgas1,2, Johan Engblom1,2

1 – Department of Biomedical Science, Faculty of Health and Society, Malmö University, SE-205 06 Malmö, Sweden.
2 – Biofilms-Research Center for Biointerfaces (BRCB), Malmö University, SE-205 06 Malmö, Sweden.
3 – Scantox Lund (Timeline Bioresearch AB), Scheelevägen 2, SE-223 63 Lund, Sweden.
4 – Galenica AB, Medeon Science Park, SE-205 12 Malmö, Sweden.
5 – Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, SE-205 02 Malmö, Sweden.
6 – Department of Solid Mechanics & MAX IV Laboratory, Lund University, SE-221 00 Lund, Sweden.
7 – Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden.
8 – Copenhagen Wound Healing Center, Bispebjerg Hospital, Department of Biomedical Sciences, University of Copenhagen, DK-2400 Copenhagen, Denmark.

10.3390/biomedicines9040360pubmed.ncbi.nlm.nih.gov/33807251/discoverywound-healinggottingen-minipig
Behavioral Biology of Pigs and Minipigs2021

Sandra Edwards, Nanna Grand

Book: Behavioral Biology of Laboratory Animals, ISBN: 9780429019517www.taylorfrancis.com/chapters/edit/10.1201/9780429019517-17/behavioral-biology-pigs-minipigs-sandra-edwards-nanna-grand?context=ubx&refId=473a7a55-7628-4173-904a-641631685bdbregulatory-toxicologyothergottingen-minipig
Enhanced Seroconversion to West Nile Virus Proteins in Mice by West Nile Kunjin Replicon Virus-like Particles Expressing Glycoproteins from Crimean–Congo Hemorrhagic Fever Virus2018

Pham-Tue-Hung Tran1, Urban Höglund2, Olivia Larsson2, Sofia Appelberg3, Ali Murazimi4,5, Magnus Johansson1,
Wessam Melin1

1 – School of Medical Science, Inflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, 703 62 Örebro, Sweden
2 – Scantox Solna (Adlego Biomedical AB), P.O. Box 42, 751 03 Uppsala, Sweden
3 – Department of Microbiology, Public Health Agency of Sweden, 171 82 Solna, Sweden
4 – Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institution, 141 52 Huddinge, Sweden
5 – National Veterinary Institute, 751 89 Uppsala, Sweden

10.3390/pathogens11020233www.mdpi.com/2076-0817/11/2/233discoveryothermice
Macromolecular Viral Entry Inhibitors as Broad‐Spectrum First‐Line Antivirals with Activity against SARS‐CoV‐22019

Rüdiger Groß1, Lívia Mesquita Dias Loiola2,3, Leila Issmail4, Nadja Uhlig4, Valentina Eberlein4, Carina Conzelmann1, Lia‐Raluca Olari1, Lena Rauch1, Jan Lawrenz1, Tatjana Weil1, Janis A. Müller1, Mateus Borba Cardoso3, Andrea Gilg1, Olivia Larsson5, Urban Höglund5, Sandra Axberg Pålsson6, Anna Selch Tvilum2, Kaja Borup Løvschall2, Maria M. Kristensen2, Anna‐Lena Spetz6, Fortune Hontonnou7, Marie Galloux7, Thomas Grunwald4, Alexander N. Zelikin2,  Jan Münch1

1 – Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081 Germany
2 – Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus 8000 Denmark
3 – Brazilian Synchrotron Light Laboratory, Brazilian Center for Research in Energy and Materials, Campinas São Paulo, 13083‐970 Brazil
4 – Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig 04103 Germany
5 – Scantox Solna (Adlego Biomedical AB), Solna 171 65 Sweden
6 – Department of Molecular Biosciences, The Wenner‐Gren Institute Stockholm University, Stockholm 10691 Sweden
7 – Université Paris‐Saclay, INRAE, UVSQ, VIM, Jouy‐en‐Josas 78352 France

10.1002/advs.202201378www.ncbi.nlm.nih.gov/pmc/articles/PMC9284172/discoverysars-covmice
A universal SARS-CoV DNA vaccine inducing highly cross-reactive neutralizing antibodies and T cells2024

Sofia Appelberg 1, Gustaf Ahlén2, Jingyi Yan2, Negin Nikouyan2, Sofie Weber3, Olivia Larsson3, Urban Höglund3,
Soo Aleman4, Friedemann Weber5, Emma Perlhamre6, Johanna Apro6, Eva‐Karin Gidlund7, Ola Tuvesson7, Simona Salati8, Matteo Cadossi8, Hanna Tegel9, Sophia Hober9, Lars Frelin2, Ali Mirazimi1, and Matti Sällberg2

1 – Public Health Agency of Sweden Solna Sweden
2 – Department of Laboratory Medicine Karolinska Institutet Huddinge Sweden
3 – Scantox Solna (Adlego AB) Uppsala Sweden
4 – Department of Infectious Disease Karolinska University Hospital Huddinge Sweden
5 – Institute for Virology, FB10‐Veterinary Medicine, Justus‐Liebing University Giessen Giessen Germany
6 – Karolinska Trial Alliance Karolinska University Hospital Huddinge Sweden
7 – NorthX Biologics Matfors Sweden
8 – IGEA Bomedical Spa Carpi Italy
9 – Department of Protein Science Royal Institute of Technology Stockholm Sweden

10.15252/emmm.202215821www.embopress.org/doi/full/10.15252/emmm.202215821discoverysars-covmice
Development of a Multivalent Kunjin Virus Reporter Virus-Like Particle System Inducing Seroconversion for Ebola and West Nile Virus Proteins in Mice2022

Pham-Tue-Hung Tran1, Naveed Asghar1, Urban Höglund2, Olivia Larsson2, Lars Haag3, Ali Mirazimim4,5,
Magnus Johansson1, Wessam Melik1

1 – School of Medical Science, Inflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, 703 62 Örebro, Sweden
2 – Scantox Solna (Adlego Biomedical AB), P.O. Box 42, 751 03 Uppsala, Sweden
3 – EM Unit (EMil), Department of Laboratory Medicine, Karolinska Institute, 171 77 Solna, Sweden
4 – Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden
5 – National Veterinary Institute, 751 89 Uppsala, Sweden

10.3390/microorganisms8121890www.mdpi.com/2076-2607/8/12/1890discoveryebolamice
Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-22021

Wael Bahnan, Sebastian Wrighton, martin Sundwall, Anna läckberg, Olivia Larsson, Urban Höglund, Hamed Khakzad, Magdalena Godzwon, Maria Walle, Elisabeth Elder, Anna Söderlund Strand, Lotta Happonen, Oscar André, Johannes Kumra Ahnlide, Thoms Hellmark, Vidar Wendel-Hansen, Robert PS Wallin, Johan Malmström, lars Malmström, Mats Ohlin, Magnus Rasmussen, Pontus Nordenfelt

10.3389/fimmu.2021.808932 www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.808932/fulldiscoverysars-covmice
The Non-Human Primate in Safety Assessment of a Bifunctional Long-Acting Insulin Analogue2023non-clinical development, non-human primates, minipigs, cynomolgus monkey, safety assessment, long-acting insulin, PCSK9i

Vivi FH Jensen DVM PhD1, Nikolai K Jensen DVM1, Line H Schefe PhD1, Jens Sigh PhD1, Akiyemi Akintomide MSc2,
Kari Kaaber DVM3, Sophia G Moesgaard DVM PhD4, Mona H Pedersen PhD1

1 – Global Drug Discovery and Development Sciences, Novo Nordisk A/S, Maaloev, Denmark
2 – Labcorp Early Development Laboratories Limited, Huntingdon, UK
3 – Scantox A/S, Lille Skensved, Denmark
4 – Y-mAbs Therapeutics A/S, Hørsholm, Denmark

10.1177/10915818231156898journals.sagepub.com/doi/10.1177/10915818231156898regulatory-toxicologyotherother
Alginate and Nanocellulose Dressings With Extract From Salmon Roe Reduce Inflammation and Accelerate Healing of Porcine Burn Wounds2023Anti-inflammatory agents, oxidative stress, inflammation, alginates, bandages, burns, interleukins, macrophages, salmon, suidae, swine, miniature, wound healing, dressing of skin or wounds, inflammatory response, partial thickness burns

Karin M Gilljam PhD, Patrik Stenlund PhD, Simon Standort MSc, Sisse Bindslev Andersen DVM,
Kari Kaaber DVM, Henrik Lund MD PhD, Karl R K Bryn MD

10.1093/jbcr/irad006academic.oup.com/jbcr/article/44/5/1140/6987519?login=falsediscoverywound-healinggottingen-minipig
Subclass-switched anti-spike IgG3 oligoclonal cocktails strongly enhance Fc-mediated opsonization2023Fc-mediated function; affinity; oligoclonal; phagocytosis; subclass

Arman Izadi1, Arsema Hailu1, Magdalena Godwon2, Sebastian Wrighton1, Berit Olofsson1, Tobias Schmidt3,4, Anna Söderlund-Strand5, Elizabeth Elder6, Sofia Appelberg7, Maria Valsjö8, Olivia Larsson8, Vidar Wendel-Hansen9, Mats Ohlin2,10, Wael Bahnan1, Pontus Nordenfelt1,5.

1 – Department of Clinical Sciences Lund, Division of Infection Medicine, Faculty of Medicine, Lund University, 221 84 Lund, Sweden.
2 – Department of Immunotechnology, Faculty of Engineering, Lund University, 221 00 Lund, Sweden.
3 – Department of Clinical Sciences Lund, Division of Pediatrics, Faculty of Medicine, Lund University, 221 84 Lund, Sweden.
4 – Wallenberg Center for Molecular Medicine, Faculty of Medicine, Lund University, 221 84 Lund, Sweden.
5 – Department of Laboratory Medicine, Clinical Microbiology, Skåne University Hospital Lund, Lund University, 221 85 Lund, Sweden.
6 – Department of Microbiology, National Veterinary Institute, 751 89 Uppsala, Sweden.
7 – Department of Microbiology, Public Health Agency of Sweden, 171 82 Stockholm, Sweden.
8 – Scantox A/S, 171 65 Stockholm, Sweden.
9 – Tanea Medical AB, 751 83 Uppsala, Sweden.
10 – SciLifeLab Drug Discovery and Development, Lund University, 221 00 Lund, Sweden.

10.1073/pnas.2217590120 pubmed.ncbi.nlm.nih.gov/37011197/discoverysars-covmice
Iodine loaded nanoparticles with commercial applicability increase survival in mice cancer models with low degree of side effects2024cytotoxic; drug delivery; molecular iodine; nanoparticles; side effects.

Torkel Falkenberg, Olivia Larsson, Bengt Hedin, Shigeru Shiraki, Takahisa Karita

10.1002/cnr2.1843pubmed.ncbi.nlm.nih.gov/37269144/discoverycancermice
"First virological and pathological study of Göttingen Minipigs with Dippity Pig Syndrome (DPS)"2023

Hina Jhelum, Nanna Grand, Kirsten Rosenmay Jacobsen, Sabrina Halecker, Michelle Salerno, Robert Prate, Luise Krüger, Yannick Kristiansen, Ludwig Krabben, Lars Möller, Michael Laue, Benedikt Kaufer, Kari Kaaber, Joachim Denner

Laboratory of Joachim Denner at the Robert Koch Institute and the
Institute of Virology was supported by the Deutsche Forschungsgemeinschaft, TRR127.

10.1371/journal.pone.0281521journals.plos.org/plosone/article?id=10.1371/journal.pone.0281521regulatory-toxicologydippity-pig-syndromegottingen-minipig
Comparison of efficacy between subcutaneous and intravenous application of moss-aGal in the mouse model of Fabry disease2023enzyme replacement therapy, Fabry disease, moss-aGal, subcutaneous application

Paulina Dabrowska-Schlepp1, Andreas Busch1, Jin-Song Shen2, Rachel Y. Cheong3, Lone Bruhn Madsen3, Daniel Mascher4, Raphael Schiffmann2, Andreas Schlaaf1

1 – Eleva GmbH, Freiburg, Germany
2 – Institute of Metabolic Disease, Baylor, Scott & White Research Institute, Dallas, Texas, USA
3 – Scantox Sweden (Previously Timeline Bioresearch AB), Lund, Sweden
4 – pharm-analyt Labor GmbH, Baden, Austria

10.1002/jmd2.12393scantox.com/wp-content/uploads/2023/09/JIMD-Reports-2023-DabrowskaSchlepp.pdfdiscoveryfabry-diseasemice
Plasma pharmacokinetic and metabolism of [18F]THK-5317 are dependent on sex2020(S)-[(18)F]THK-5117; Metabolism; Pharmacokinetic; Sex-dependent; [(18)F]THK-5317.

Severin Mairinger 1, Thomas Filip 1, Michael Sauberer 1, Stefanie Flunkert 2, Thomas Wanek 1, Johann Stanek 1, Sara Furtner 1, Birgit Hutter-Paier 2, Nobuyuki Okamura 3, Claudia Kuntner 4

1 – Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, 2444 Seibersdorf, Austria.
2 – Neuropharmacology, QPS Austria GmbH, Grambach, Austria.
3 – Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
4 – Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, 2444 Seibersdorf, Austria. Electronic address: claudia.kuntner@ait.ac.at.

10.1016/j.nucmedbio.2020.01.001pubmed.ncbi.nlm.nih.gov/31981857/discoveryrats
Characterization of the visceral and neuronal phenotype of 4L/PS-NA mice modeling Gaucher disease.2020,

Victoria Schiffer 1, Estibaliz Santiago-Mujika 1, Stefanie Flunkert 1, Staffan Schmidt 2, Martina Farcher 1, Tina Loeffler 1, Irene Schilcher 1, Maria Posch 1, Joerg Neddens 1, Ying Sun 3 4, Jan Kehr 2, Birgit Hutter-Paier 1

1 – QPS Austria GmbH, Neuropharmacology, Grambach, Austria.
2 – Pronexus Analytical AB, Bromma, Sweden.
3 – Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America.
4 – Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.

10.1371/journal.pone.0227077pubmed.ncbi.nlm.nih.gov/31929594/discoverygaucher-disease4l-ps-na-mice mice
Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer’s-like mice.2020APPSWE/PS1ΔE9; Immunotherapy; Microhemorrhage; Phagocytosis; Pyroglutamate-3 amyloid-β; microPET.

Helen Crehan 1 2, Bin Liu 1 2, Martin Kleinschmidt 3 4, Jens-Ulrich Rahfeld 3 4, Kevin X Le 1, Barbara J Caldarone 2 5, Jeffrey L Frost 1, Thore Hettmann 3, Birgit Hutter-Paier 6, Brian O’Nuallain 1 2, Mi-Ae Park 2 7, Marcelo F DiCarli 2 7, Inge Lues 3, Stephan Schilling 3 4, Cynthia A Lemere 8 9

1 – Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Hale BTM 9002S, 60 Fenwood Rd, Boston, MA, 02115, USA.
2 – Harvard Medical School, Boston, MA, USA.
3 – Vivoryon Therapeutics AG, Halle (Saale), Germany.
4 – Department Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology, Halle (Saale), Germany.
5 – Mouse Behavior Core, Harvard Medical School, Boston, MA, USA.
6 – QPS Austria, Grambach, Austria.
7 – Department of Radiology, Brigham Women’s Hospital, Boston, MA, USA.
8 – Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Hale BTM 9002S, 60 Fenwood Rd, Boston, MA, 02115, USA. clemere@bwh.harvard.edu.
9 – Harvard Medical School, Boston, MA, USA. clemere@bwh.harvard.edu.

10.1186/s13195-019-0579-8pubmed.ncbi.nlm.nih.gov/31931873/discoveryadappslxhqc
The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies2020, , Leukotrienes; Montelukast; alpha-synulcein; autophagy; cognition; dementia; neuroinflammation.

Julia Marschallinger # 1 2, Barbara Altendorfer # 1 2, Edward Rockenstein 3, Miriam Holztrattner 1 2, Julia Garnweidner-Raith 1 2, Nadine Pillichshammer 1 2, Iris Leister 1 2, Birgit Hutter-Paier 4, Katharina Strempfl 1 2 4, Michael S Unger 1 2, Mansoor Chishty 5, Thomas Felder 6, Mary Johnson 7, Johannes Attems 7, Eliezer Masliah 3, Ludwig Aigner 8 9 10

1 – Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria.
2 – Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.
3 – Department of Neuroscience, School of Medicine, University of California San Diego, San Diego, USA.
4 – QPS Austria GmbH, Neuropharmacology, Grambach, Austria.
5 – Pharmidex, London, W1S 1RR, UK.
6 – Department of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria.
7 – Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
8 – Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria. ludwig.aigner@pmu.ac.at.
9 – Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria. ludwig.aigner@pmu.ac.at.
10 – Austrian Cluster for Tissue Regeneration, Vienna, Austria. ludwig.aigner@pmu.ac.at.
#Contributed equally.

10.1007/s13311-020-00836-3pubmed.ncbi.nlm.nih.gov/32072462/discoverylewy-body-dementia pdd-line-mice human
Transgene integration causes RARB downregulation in homozygous Tg4-42 mice2020

Barbara Hinteregger 1 2, Tina Loeffler 1, Stefanie Flunkert 3, Joerg Neddens 1, Ruth Birner-Gruenberger 2 4 5 6, Thomas A Bayer 7, Tobias Madl 2 5, Birgit Hutter-Paier 1

1 – QPS Austria GmbH, Parkring 12, 8074, Grambach, Austria.
2 – Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging) Division of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
3 – QPS Austria GmbH, Parkring 12, 8074, Grambach, Austria.
4 – Diagnostic and Research Institute of Pathology & Omics Center Graz, Medical University of Graz, Graz, Austria.
5 – BioTechMed-Graz, Graz, Austria.
6 – Vienna University of Technology, Institute of Chemical Technologies and Analytics, Vienna, Austria.
7 – Department of Psychiatry and Psychotherapy, Division of Molecular Psychiatry, University Medical Center Göttingen (UMG), Göttingen, Germany.

10.1038/s41598-020-63512-8pubmed.ncbi.nlm.nih.gov/32286473/discoveryadtg4-42-mice
CD8+ T-cells infiltrate Alzheimer's disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice2020, Alzheimer’s disease; Arc; CD8(+) T-cells; Npas4; RNAseq; Synapse.

M S Unger 1, E Li 1, L Scharnagl 1, R Poupardin 2, B Altendorfer 1, H Mrowetz 1, B Hutter-Paier 3, T M Weiger 4, M T Heneka 5, J Attems 6, L Aigner 7

“1 – Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.
2 – Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria; Experimental and Clinical Cell Therapy Institute, Paracelsus Medical University, Salzburg, Austria.
3 – QPS Austria GmbH, Parkring 12, 8074 Grambach, Austria.
4 – Department of Biosciences, University of Salzburg, Salzburg, Austria.
5 – German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital of Bonn, Bonn, Germany.
6 – Translational and Clinical Institute, Newcastle University, Newcastle upon Tyne, UK.
7 – Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria; Austrian Cluster for Tissue Regeneration, Austria. Electronic address: ludwig.aigner@pmu.ac.at.”

Alzheimer’s disease; Arc; CD8(+) T-cells; Npas4; RNAseq; Synapse.pubmed.ncbi.nlm.nih.gov/32479993/discoveryadapp-ps1-mice mice
Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value2020, , , , , , , Neurofilament-light chain; animal model; biomarker; cerebrospinal fluid; lysosomal storage diseases; neurodegenerative disease; plasma; preclinical research.

Tina Loeffler 1, Irene Schilcher 1, Stefanie Flunkert 1, Birgit Hutter-Paier 1

1 – Neuropharmacology, QPS Austria GmbH, Grambach, Austria.

10.3389/fnins.2020.00579pubmed.ncbi.nlm.nih.gov/32595447/discoveryad als gaucher-disease pd4l-ps-na-mice 5xfad-mice line-61-mice sod1-g93a-mice tar6-6-mice
Validation of behavioral phenotypes in the BACHD rat model2020, BACHD rats; Behavioral phenotype validation; Behavioral phenotyping.

Arianna Novati 1, Giuseppe Manfré 2, Stefanie Flunkert 3, Johanneke E Van der Harst 4, Judith R Homberg 5, Robert Wronski 3, Huu Phuc Nguyen 6

1 – Institute of Medical Genetics and Applied Genomics, University of Tübingen, Calwerstrasse7, 72076, Tübingen, Germany; Centre for Rare Diseases, University of Tübingen, Calwerstrasse7, 72076, Tübingen, Germany; QPS Austria GmbH, Neuropharmacology, Parkring 12, 8074, Grambach, Austria; Department of Human Genetics, Ruhr University Bochum, Universitätsstraße 150, 44801, Bochum, Germany.
2 – Institute of Medical Genetics and Applied Genomics, University of Tübingen, Calwerstrasse7, 72076, Tübingen, Germany; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Postbus 9104, 6500 HE, Nijmegen, the Netherlands; Noldus Information Technology BV, Nieuwe Kanaal 5, 6709 PA, Wageningen, the Netherlands.
3 – QPS Austria GmbH, Neuropharmacology, Parkring 12, 8074, Grambach, Austria.
4 – Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Postbus 9104, 6500 HE, Nijmegen, the Netherlands; Noldus Information Technology BV, Nieuwe Kanaal 5, 6709 PA, Wageningen, the Netherlands.
5 – Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Postbus 9104, 6500 HE, Nijmegen, the Netherlands.
6 – Institute of Medical Genetics and Applied Genomics, University of Tübingen, Calwerstrasse7, 72076, Tübingen, Germany; Centre for Rare Diseases, University of Tübingen, Calwerstrasse7, 72076, Tübingen, Germany; Department of Human Genetics, Ruhr University Bochum, Universitätsstraße 150, 44801, Bochum, Germany. Electronic address: huu.nguyen-r7w@ruhr-uni-bochum.de.

10.1016/j.bbr.2020.112783pubmed.ncbi.nlm.nih.gov/32574646/discoveryhdbachd-rats rats
Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer's disease and related murine models2020, , ,

Joerg Neddens 1, Magdalena Daurer 1, Stefanie Flunkert 1, Kerstin Beutl 1 2, Tina Loeffler 1, Lauren Walker 3, Johannes Attems 3, Birgit Hutter-Paier 1

1 – QPS Austria GmbH, Grambach, Austria.
2 – FH Joanneum Graz, Graz, Austria.
3 – Translational and Clinical Research Institute and Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.

10.1371/journal.pone.0235543www.ncbi.nlm.nih.gov/pmc/articles/PMC7347153/discoveryad5xfad-mice appsl-mice human mice
Constant Levels of Tau Phosphorylation in the Brain of htau Mice2020, , Alzheimer’s disease; genetic background; human tau; immunofluorescent labelling; mouse model; phosphorylation; progression; tauopathies.

Joerg Neddens 1, Magdalena Daurer 1, Tina Loeffler 1, Saioa Alzola Aldamizetxebarria 1, Stefanie Flunkert 1, Birgit Hutter-Paier 1

1 – QPS Austria GmbH, Grambach, Austria.

10.3389/fnmol.2020.00136pubmed.ncbi.nlm.nih.gov/32982685/discoveryad tauopathieshtau-mice mice
Improved Bioavailability of Montelukast through a Novel Oral Mucoadhesive Film in Humans and Mice2020, Alzheimer’s disease; dementia; drug delivery; montelukast.

Johanna Michael 1, Diana Bessa de Sousa 1, Justin Conway 2, Erick Gonzalez-Labrada 2, Rodolphe Obeid 2, Julia Tevini 3, Thomas Felder 3, Birgit Hutter-Paier 4, Horst Zerbe 2, Nadine Paiement 2, Ludwig Aigner 1 4 5

1 – Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria.
2 – IntelgenX Corp., Saint-Laurent, QC H4S 1Y2, Canada.
3 – Department of Laboratory Medicine, Paracelsus Medical University, 5020 Salzburg, Austria.
4 – QPS Neuropharmacology, 8074 Grambach/Graz, Austria.
5 – Austrian Cluster of Tissue Regeneration Affiliation, 1200 Vienna, Austria.

10.3390/pharmaceutics13010012www.ncbi.nlm.nih.gov/pmc/articles/PMC7822410/adc57bl6-mice human
Quantification of Huntington’s Disease Related Markers in the R6/2 Mouse Model2021, Ctip2; Huntington animal model; TSPO; histological evaluation; quantification.

Estibaliz Etxeberria-Rekalde 1, Saioa Alzola-Aldamizetxebarria 1, Stefanie Flunkert 1, Isabella Hable 1 2, Magdalena Daurer 1, Joerg Neddens 1, Birgit Hutter-Paier 1

1- QPS Austria GmbH, Grambach, Austria.
2 – Department of Health Studies, FH Joanneum University of Applied Sciences, Graz, Austria.

10.3389/fnmol.2020.617229www.ncbi.nlm.nih.gov/pmc/articles/PMC7831778/discoveryhdmice r6-2-mice
Bispecific Tau Antibodies with Additional Binding to C1q or Alpha-Synuclein2021, Alpha-synuclein; Alzheimer’s disease; C1q; immunotherapy; synucleinopathies; tau; tauopathies.

Wim Hendricus Quint 1, Irena Matečko-Burmann 2 3, Irene Schilcher 4, Tina Löffler 4, Michael Schöll 2 3 5, Björn Marcus Burmann 2 6, Thomas Vogels 1 3 5

1 – Maptimmune BV, The Hague, The Netherlands.
2 – Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.
3 – Department of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden.
4 – QPS Austria GmbH, Neuropharmacology, Grambach, Austria.
5 – Department of Neurodegenerative Disease, UCL Queen Square, Institute of Neurology, University College London, London, UK.
6 – Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.

10.3233/JAD-201334pubmed.ncbi.nlm.nih.gov/33579845/discoveryad tauopathieshuman
Homozygosity of BACHD rats not only causes strong behavioral deficits in young female rats but also a reduced breeding success2021, Behavioral analysis; Breeding success; Homozygosity; Huntington’s disease; Learning and memory; Sex differences.

Stephan Kurat, Petra Heinrich, Agnes Molnar-Kasza, Tina Loeffler, Stefanie Flunkert, Birgit Hutter-Paier

QPS Austria GmbH, Neuropharmacology, Parkring 12, 8074 Grambach, Austria.

10.1016/j.brainres.2021.147396pubmed.ncbi.nlm.nih.gov/33662341/discoveryhdbachd-rats rats
The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice2021, 5xFAD; Alzheimer’s disease; RNAseq; cognition; cysteinyl leukotrienes; leukotriene receptor antagonist; microglia; montelukast.

Johanna Michael 1 2, Julia Zirknitzer 1 2, Michael Stefan Unger 1 2, Rodolphe Poupardin 2, Tanja Rieß 1 2, Nadine Paiement 3, Horst Zerbe 3, Birgit Hutter-Paier 4, Herbert Reitsamer 5, Ludwig Aigner 1 2 6

1 – Institute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria.
2 – Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, 5020 Salzburg, Austria.
3 – IntelgenX Corp., Saint-Laurent, QC H4S 1Y2, Canada.
4 – QPS Neuropharmacology, 8074 Grambach/Graz, Austria.
5 – Research Program for Experimental Ophthalmology, Department of Ophthalmology and Optometry, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.
6 – Austrian Cluster of Tissue Regeneration, 1200 Vienna, Austria.

10.3390/ijms22052782www.ncbi.nlm.nih.gov/pmc/articles/PMC7967180/discoveryad5xfad-mice mice
Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer's Disease2021, Alzheimer’s disease; behavior; biomarkers; neuroinflammation; neuronal degeneration; nuclear magnetic resonance.

Barbara Hinteregger 1 2, Tina Loeffler 1, Stefanie Flunkert 1, Joerg Neddens 1, Thomas A Bayer 3, Tobias Madl 2 4, Birgit Hutter-Paier 1

1 – QPS Austria GmbH, Grambach, Austria.
2 – Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
3 – Department of Psychiatry and Psychotherapy, Division of Molecular Psychiatry, University Medical Center, Göttingen (UMG), Göttingen, Germany.
4 – BioTechMed-Graz, Graz, Austria.

10.3233/JAD-201204www.ncbi.nlm.nih.gov/pmc/articles/PMC8150512/discoveryadmice tg4-42-mice
Evaluation of Neuropathological Features in the SOD1-G93A Low Copy Number Transgenic Mouse Model of Amyotrophic Lateral Sclerosis2021, neuroinflammation, muscle phenotype, spinal cord, survival rate, muscle strength, body weight

Agnes Molnar-Kasza 1, Barbara Hinteregger 1, Joerg Neddens 1, Roland Rabl 1, Stefanie Flunkert 1, Birgit Hutter-Paier 1

1 – QPS Austria GmbH, Grambach, Austria.

10.3389/fnmol.2021.681868pubmed.ncbi.nlm.nih.gov/34248499/discoveryalsmice sod1-g93a-mice
Characterization of an APP/tau rat model of Alzheimer's disease by positron emission tomography and immunofluorescent labeling2021, Alzheimer’s disease; Immunohistochemistry; Rat model; [11C]PiB; [18F]THK-5317.

Thomas Filip 1 2, Severin Mairinger 1 3, Joerg Neddens 4, Michael Sauberer 1 5, Stefanie Flunkert 4, Johann Stanek 1 5, Thomas Wanek 1 5, Nobuyuki Okamura 6, Oliver Langer 1 3 5, Birgit Hutter-Paier 4, Claudia Kuntner 7 8

1 – Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, 2444, Seibersdorf, Austria.
2 – Department of Biomedical Research, Medical University Vienna, Vienna, Austria.
3 – Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
4 – Neuropharmacology, QPS Austria GmbH, Grambach, Austria.
5 – Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
6 – Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
7 – Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, 2444, Seibersdorf, Austria. claudia.kuntner@meduniwien.ac.at.
8 – Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. claudia.kuntner@meduniwien.ac.at.
#Contributed equally.

10.1186/s13195-021-00916-2www.ncbi.nlm.nih.gov/pmc/articles/PMC8522096/discoveryadapp-tau-rats rats
CD4+ T cells contribute to neurodegeneration in Lewy body dementia2021,

David Gate 1 2 3, Emma Tapp 2 3, Olivia Leventhal 2 3, Marian Shahid 2, Tim J Nonninger 2 3, Andrew C Yang 4 5, Katharina Strempfl 6 7 8, Michael S Unger 6 7, Tobias Fehlmann 9, Hamilton Oh 2 3, Divya Channappa 2, Victor W Henderson 2, Andreas Keller 2 9, Ludwig Aigner 6 7, Douglas R Galasko 10, Mark M Davis 11 12, Kathleen L Poston 2, Tony Wyss-Coray 2 3 5

1 – Department of Neurology, Northwestern University, Chicago, IL, USA.
2 – Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
3 – Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
4 – Department of Bioengineering, Stanford University, Stanford, CA, USA.
5 – Chemistry, Engineering, and Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA.
6 – Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria.
7 – Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria.
8 – QPS Austria GmbH, Parkring 12, 8074 Grambach, Austria.
9 – Chair for Clinical Bioinformatics, Saarland University, Saarbrucken, Germany.
10 – Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
11 – Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, CA, USA.
12 – Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.

10.1126/science.abf7266www.ncbi.nlm.nih.gov/pmc/articles/PMC9122025/discoveryad lewy-body-dementiahuman
A brain proteomic signature of incipient Alzheimer's disease in young APOE ε4 carriers identifies novel drug targets2021Alzheimer’s disease; anti-pyroglutamyl β-amyloid antibody; drug combination; glutaminyl cyclase inhibitor; hAPPsl×hQC mice; immunotherapy

Jackson A Roberts 1 2, Vijay R Varma 1, Yang An 3, Sudhir Varma 4, Julián Candia 5 6, Giovanna Fantoni 7, Vinod Tiwari 8, Carlos Anerillas 9, Andrew Williamson 1, Atsushi Saito 10, Tina Loeffler 11, Irene Schilcher 11, Ruin Moaddel 12, Mohammed Khadeer 12, Jacqueline Lovett 12, Toshiko Tanaka 6, Olga Pletnikova 10 13, Juan C Troncoso 10 14, David A Bennett 15, Marilyn S Albert 14, Kaiwen Yu 16, Mingming Niu 16, Vahram Haroutunian 17 18, Bin Zhang 19, Junmin Peng 16, Deborah L Croteau 8, Susan M Resnick 3, Myriam Gorospe 9, Vilhelm A Bohr 8, Luigi Ferrucci 6, Madhav Thambisetty 1

1 – Clinical and Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
2 – Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032.
3 – Brain Aging and Behavior Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
4 – HiThru Analytics, Laurel, MD 20707, USA.
5 – Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
6 – Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
7 – Clinical Research Core, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
8 – Section on DNA Repair, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
9 – Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
10 – Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
11 – QPS Austria GmbH, Parkring 12, 8074 Grambach, Austria.
12 – Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
13 – Department of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
14 – Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
15 – Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
16 – Departments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
17 – Departments of Psychiatry and Neuroscience, The Alzheimer’s Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
18 – Mental Illness Research, Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, NY 10468, USA.
19 – Department of Genetics and Genomic Sciences and Department of Pharmacological Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

10.1126/sciadv.abi8178www.ncbi.nlm.nih.gov/pmc/articles/PMC8580310/discoveryadhuman
Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mice2021, Alzheimer’s disease; anti-pyroglutamyl β-amyloid antibody; drug combination; glutaminyl cyclase inhibitor; hAPPsl×hQC mice; immunotherapy.

Torsten Hoffmann 1, Jens-Ulrich Rahfeld 2, Mathias Schenk 2, Falk Ponath 3, Koki Makioka 3, Birgit Hutter-Paier 4, Inge Lues 1, Cynthia A Lemere 3, Stephan Schilling 2 5

1 – Vivoryon Therapeutics N.V., Weinbergweg 22, 06120 Halle, Germany.
2 – Fraunhofer Institute for Cell Therapy and Immunology, Department of Drug Design and Target Validation, Weinbergweg 22, 06120 Halle, Germany.
3 – Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, 60 Fenwood Rd., Boston, MA 02115, USA.
4 – QPS Austria GmbH, Department of Neuropharmacology, Parkring 12, A-8074 Grambach, Austria.
5 – Anhalt University of Applied Sciences, Bernburger Straße 55, 06366 Köthen, Germany.

10.3390/ijms222111791www.ncbi.nlm.nih.gov/pmc/articles/PMC8584206/discoveryadappxhqc-mice mice
Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation2021,

Kristina Dominko 1, Ana Rastija 1, Sandra Sobocanec 2, Lea Vidatic 1, Sarah Meglaj 3, Andrea Lovincic Babic 3, Birgit Hutter-Paier 4, Alessio-Vittorio Colombo 5, Stefan F Lichtenthaler 5 6 7, Sabina Tahirovic 5, Silva Hecimovic 1

1 – Laboratory for Neurodegenerative Disease Research, Division of Molecular Medicine, Ruder Boskovic Institute, 10000 Zagreb, Croatia.
2 – Laboratory for Mitochondrial Bioenergetics and Diabetes, Division of Molecular Medicine, Ruder Boskovic Institute, 10000 Zagreb, Croatia.
3 – Division of Biology, Faculty of Science, University of Zagreb, 10000 Zagreb, Croatia.
4 – QPS Austria GmbH, 8074 Grambach, Austria.
5 – German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.
6 – Neuroproteomics, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
7 – Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.

10.3390/ijms222413256www.ncbi.nlm.nih.gov/pmc/articles/PMC8705785/discoveryniemann-pick-diseasemice npc1-mice
Leukotriene Signaling as a Target in α-Synucleinopathies2022, Montelukast; Parkinson’s disease; dementia with Lewy bodies; leukotriene signaling pathway; α-synucleinopathy

Katharina Strempfl 1 2 3, Michael S Unger 1 2, Stefanie Flunkert 3, Andrea Trost 4, Herbert A Reitsamer 4, Birgit Hutter-Paier 3, Ludwig Aigner 1 2

1 – Institute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria.
2 – Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, 5020 Salzburg, Austria.
3 – QPS Austria GmbH, Neuropharmacology, 8074 Grambach, Austria.
4 – University Clinic of Ophthalmology and Optometry, Research Program for Ophthalmology and Glaucoma Research, Paracelsus Medical University, 5020 Salzburg, Austria.

10.3390/biom12030346www.ncbi.nlm.nih.gov/pmc/articles/PMC8944962/discoverypdalpha-synuclein-mouse-models mice
No association between initiation of phosphodiesterase-5 inhibitors and risk of incident Alzheimer's disease and related dementia: results from the Drug Repurposing for Effective Alzheimer's Medicines study2022Alzheimer’s disease; PDE5 inhibitors; cohort study; dementia; repurposing

Rishi J Desai 1, Mufaddal Mahesri 1, Su Been Lee 1, Vijay R Varma 2, Tina Loeffler 3, Irene Schilcher 3, Tobias Gerhard 4 5, Jodi B Segal 6, Mary E Ritchey 4, Daniel B Horton 4 7, Seoyoung C Kim 1 8, Sebastian Schneeweiss 1, Madhav Thambisetty 2

1 – Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital & Harvard Medical School, Boston, MA 02115, USA.
2 – Clinical & Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD 21224, USA.
3 – QPS Austria GmbH, Parkring 12, 8074 Grambach, Austria.
4 – Rutgers Center for Pharmacoepidemiology and Treatment Science, New Brunswick, NJ 08901, USA.
5 – Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
6 – Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
7 – Rutgers Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08901, USA.
8 – Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

10.1093/braincomms/fcac247www.ncbi.nlm.nih.gov/pmc/articles/PMC9598543/discoveryadhuman
Hydroxychloroquine lowers Alzheimer's disease and related dementias risk and rescues molecular phenotypes related to Alzheimer's disease2022, Psychiatric disorders, Drug discovery

Vijay R Varma 1, Rishi J Desai 2, Sheeja Navakkode 3 4, Lik-Wei Wong 4 5, Carlos Anerillas 6, Tina Loeffler 7, Irene Schilcher 7, Mufaddal Mahesri 2, Kristyn Chin 2, Daniel B Horton 8, Seoyoung C Kim 2, Tobias Gerhard 8, Jodi B Segal 9, Sebastian Schneeweiss 2, Myriam Gorospe 6, Sreedharan Sajikumar 4 5 10, Madhav Thambisetty 11

1 – Clinical and Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.
2 – Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.
3 – Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
4 – Department of Physiology, National University of Singapore, Singapore, Singapore.
5 – Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
6 – Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
7 – QPS Austria GmbH, Parkring 12, 8074, Grambach, Austria.
8 – Center for Pharmacoepidemiology and Treatment Science, Ernest Mario School of Pharmacy, Rutgers University, New Brunswick, NJ, USA.
9 – Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
10 – Life Sciences Institute Neurobiology Programme, National University of Singapore, Singapore, Singapore.
11 – Clinical and Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA. thambisettym@mail.nih.gov.

10.1038/s41380-022-01912-0www.ncbi.nlm.nih.gov/pmc/articles/PMC10005941/discoveryadapp-ps2-mice mice
Evaluating the effect of R-Baclofen and LP-211 on autistic behavior of the BTBR and Fmr1-KO mouse models2023, , autism spectrum disorders, locomotor behavior, anxiety, repetitive behavior, ultrasonic vocalization, GABAB receptor agonist, 5-HT7 receptor agonist

Shirin Sharghi 1 2, Stefanie Flunkert 1, Magdalena Daurer 1, Roland Rabl 1, Boris Philippe Chagnaud 2, Marcello Leopoldo 3, Enza Lacivita 3, Birgit Hutter-Paier 1, Manuela Prokesch 1

1 – Department of Neuropharmacology, QPS Austria GmbH, Grambach, Austria.
2 – Institute for Biology, Karl-Franzens-Universität Graz, Graz, Austria.
3 – Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, Bari, Italy.

doi.org/10.3389/fnins.2023.1087788pubmed.ncbi.nlm.nih.gov/37065917/discoveryautism-spectrum-disorderbtbr-mice fmr1-ko-mice mice
Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer's disease-related blood brain barrier dysfunction and inflammation2023, Amyloid beta; Astaxanthin; Autophagy; Blood-brain barrier; Inflammation.

Joshua Adekunle Babalola 1, Magdalena Lang 2, Meekha George 3, Anika Stracke 2, Carmen Tam-Amersdorfer 2, Izaskun Itxaso 4, Domjan Lucija 4, Jelena Tadic 5, Irene Schilcher 4, Tina Loeffler 4, Stefanie Flunkert 4, Manuela Prokesch 4, Gerd Leitinger 6, Achim Lass 5, Birgit Hutter-Paier 4, Ute Panzenboeck 2, Gerald Hoefler 7

1 – Diagnostic and Research Institute of Pathology, Medical University of Graz, Austria.
2 – Otto Loewi Research Center, Division of Immunology, Medical University of Graz, Austria.
3 – Department of Obstetrics and Gynaecology, Medical University of Graz, Austria.
4 – QPS Austria GmbH, Grambach, Austria.
5 – Institute of Molecular Biosciences, University of Graz, Austria.
6 – Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Austria.
7 – Diagnostic and Research Institute of Pathology, Medical University of Graz, Austria. Electronic address: Gerald.Hoefler@uniklinikum.kages.at.

 10.1016/j.brainres.2023.148518pubmed.ncbi.nlm.nih.gov/37579986/discoveryadmurine-organotypic-hippocampal-slice-cultures primary-porcine-brain-capillary-endothelial-cells
Effect of astaxanthin in type-2 diabetes -induced APPxhQC transgenic and NTG mice2024, , Alzheimer's disease; Astaxanthin; Metabolic perturbation; Pyroglutamylation; Type 2 diabetes.

Joshua Adekunle Babalola 1, Anika Stracke 2, Tina Loeffler 3, Irene Schilcher 3, Sideromenos Spyridon 4, Stefanie Flunkert 3, Joerg Neddens 3, Ake Lignell 5, Manuela Prokesch 3, Ute Pazenboeck 2, Herbert Strobl 2, Jelena Tadic 6, Gerd Leitinger 7, Achim Lass 6, Birgit Hutter-Paier 3, Gerald Hoefler 8

1 – Diagnostic and Research Institute of Pathology Medical University of Graz, Graz, Austria.
2 – Division of Immunology and Pathophysiology, Otto Loewi Research Center, Medical University of Graz, Austria.
3 – QPS Austria GmbH, Grambach, Austria.
4 – QPS Austria GmbH, Grambach, Austria; Medical University of Vienna, Vienna, Austria.
5 – AstaReal AB, Sweden.
6 – Institute of Molecular Biosciences, University of Graz, Austria.
7 – Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Austria.
8 – Diagnostic and Research Institute of Pathology Medical University of Graz, Graz, Austria. Electronic address: gerald.hoefler@medunigraz.at.

10.1016/j.molmet.2024.101959pubmed.ncbi.nlm.nih.gov/38763496/discoveryad type-2-diabetesappxhqc-mice mice
Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms 2024, Bloodsampling; Cortisol; HPA-axis; MiniPigs; PKPD; PRACMA; Pharmacokinetics; Pharmacology; Stress

Frederik Rode 1 ,Christoffer Bundgaard 2 , Johan Areberg 2 , Lone Bruhn Madsen 3 , Ida Taavoniku 3 , Lene Hansen 2 , Johan Weisser 2 , Line Rørbæk Olsen 2 , Heidi Toft Elgaard 2 , Elin Eneberg 2 , Michael Didriksen 2

  • 1 H. Lundbeck, Copenhagen, Denmark.
  • 2 H. Lundbeck, Copenhagen, Denmark.
  • 3 Scantox Sweden, Lund, Sweden.
10.1016/j.vascn.2024.107504 pubmed.ncbi.nlm.nih.gov/38678804/discovery regulatory-toxicologygottingen-minipig
Biodistribution, persistence and lack of integration of a multigene HIV vaccine delivered by needle-free intradermal injection and electroporation2010Electroporation; Skin; Dermal; HIV; Plasmid; DNA; Bioject

Andreas Bråve a b, Lindvi Gudmundsdotter a b, Eric Sandström c, B. Kristian Haller d, David Hallengärd a b, Anna-Karin Maltais e, Alan D. King f, Richard R. Stout g, Pontus Blomberg h, Urban Höglund i, Bo Hejdeman c, Gunnel Biberfeld a, Britta Wahren a b

a – Swedish Institute for Infectious Disease Control, Solna, Sweden
b – Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
c- Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden
d – Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
e – Cyto Pulse Sciences Inc., Solna, Sweden
f – Cellectis Bioresearch, Inc., Glen Burnie MD, USA
g – Bioject Medical Technologies, Tualatin, OR, USA
h – Vecura, Karolinska University Hospital, Huddinge, Sweden
i – Visionar Preclinical AB, Uppsala, Sweden

10.1016/j.vaccine.2010.08.108www.sciencedirect.com/science/article/pii/S0264410X10014489?via%3Dihubdiscoveryhivmice
The Use of Minipigs in Non-Clinical Research2013

Peter Glerup, Nanna Grand, Mikala Skydsgaard

Scantox A/S, Lille Skensved, Denmark

10.1016/B978-0-12-415759-0.00013-3www.researchgate.net/publication/285181945_The_Use_of_Minipigs_in_Non-Clinical_Researchregulatory-toxicologyothergottingen-minipig
Repeated measurements of motor activity in rats in long-term toxicity studies2014

V. Golozoubova, T.K. Brodersen, S. Klastrup, M. Oksama, J. Løgsted, A. Makin

Scantox A/S, Lille Skensved, Denmark

10.1016/j.vascn.2014.06.007www.sciencedirect.com/science/article/abs/pii/S105687191400224X?via%3Dihubregulatory-toxicologyotherrats
Transepidermal water loss and tape stripping in minipig skin2015

A. Makin, Sisse Ellemann-Laursen, Nanna Grand, Gitte Jeppesen, T. Starostka, J. Løgsted, K. Kaaber

10.1016/j.toxlet.2015.08.781www.researchgate.net/publication/282527493_Transepidermal_water_loss_and_tape_stripping_in_minipig_skinregulatory-toxicologyothergottingen-minipig
Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer2015

Wojciech Senkowski; Xiaonan Zhang; Maria Hägg Olofsson; Ruben Isacson; Urban Höglund; Mats Gustafsson; Peter Nygren; Stig Linder; Rolf Larsson; Mårten Fryknäs

Uppsala University, Klinisk Farmakologi, ing 61 4tr, Dag Hammarskjölds Väg 18, 751 85 Uppsala, Sweden

10.1158/1535-7163.MCT-14-0792aacrjournals.org/mct/article/14/6/1504/92034/Three-Dimensional-Cell-Culture-Based-Screeningdiscoverycancermice
Changes in energy metabolism due to acute rotenone-induced mitochondrial complex I dysfunction – An in vivo large animal model2016

Michael Karlsson a b 1, Johannes K. Ehinger a b 1, Sarah Piel a b, Fredrik Sjövall a, Johanna Henriksnäs c, Urban Höglund c, Magnus J. Hansson a b, Eskil Elmér a b

a – Mitochondrial Medicine, Department of Clinical Sciences, Lund University, BMC A13, SE-221 84 Lund, Sweden
b – NeuroVive Pharmaceutical AB, Medicon Village, Scheelevägen 2, SE-233 81 Lund, Sweden
c – Scantox Solna (Adlego Biomedical AB), P.O. Box 42, SE-751 03 Uppsala, Sweden

10.1016/j.mito.2016.10.003www.sciencedirect.com/science/article/abs/pii/S1567724916302082?via%3Dihubdiscoveryothergottingen-minipig
In Vivo Electroporation Enhances the Immunogenicity of Hepatitis C Virus Nonstructural 3/4A DNA by Increased Local DNA Uptake, Protein Expression, Inflammation, and Infiltration of CD3+ T Cells

Gustaf Ahlén; Jonas Söderholm; Torunn Tjelle; Rune Kjeken; Lars Frelin; Urban Höglund; Pontus Blomberg; Michael Fons; Iacob Mathiesen; Matti Sällberg

Division of Clinical Microbiology, F68, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden

Online ISSN: 1550-6606journals.aai.org/jimmunol/article/179/7/4741/37980/In-Vivo-Electroporation-Enhances-thediscoveryhepatitis-cmice
Bladder cancer therapy without toxicity—A dose-escalation study of alpha1-oleate2020

Pham-Tue-Hung Tran1, Naveed Asghar1, Urban Höglund2, Olivia Larsson2, Lars Haag3, Ali Mirazimi4,5, Magnus Johansson1, Wessam Melik1

1 – School of Medical Science, Inflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, 703 62 Örebro, Sweden
2 – Scantox Solna (Adlego Biomedical AB), P.O. Box 42, 751 03 Uppsala, Sweden
3 – EM Unit (EMil), Department of Laboratory Medicine, Karolinska Institute, 171 77 Solna, Sweden
4 – Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden
5 – National Veterinary Institute, 751 89 Uppsala, Sweden

10.3390/microorganisms8121890www.mdpi.com/2076-2607/8/12/1890discoverycancermice
Development of an Experimental Ex Vivo Wound Model to Evaluate Antimicrobial Efficacy of Topical Formulations2021antibiotics; antimicrobial; biofilm; burn; ex vivo; wound healing; wound model.

Madalene Å Andersson1, Lone Bruhn Madsen2, Artur Schmidtchen 3,4,5, Manoj Puthia5

1 – In2Cure AB, Medicon Village, SE-22381 Lund, Sweden.
2 – Scantox Lund (Timeline Bioresearch), Medicon Village, SE-22363 Lund, Sweden.
3 – Copenhagen Wound Healing Center, Bispebjerg Hospital, Department of Biomedical Sciences, University of Copenhagen, DK-2400 Copenhagen, Denmark.
4 – Dermatology, Skåne University Hospital, SE-22185 Lund, Sweden.
5 – Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-22184 Lund, Sweden.

10.3390/ijms22095045pubmed.ncbi.nlm.nih.gov/34068733/discoverywound-healinggottingen-minipig
Probing Skin Barrier Recovery on Molecular Level Following Acute Wounds: An In Vivo/Ex Vivo Study on Pigs2021acute wound; histology; in vivo/ex vivo; lipid; pH; polarization transfer solid state NMR (PTssNMR); skin barrier; small and wide-angle X-ray diffraction (SWAXD); stratum corneum; trans-epidermal water loss (TEWL).

Enamul Haque Mojumdar 1, 2, Lone Bruhn Madsen3, Henri Hansson4, Ida Taavoniku3, Klaus Kristensen3, Christina Persson5, Anna Karin Morén4, Rajmund Mokso6, Artur Schmidtchen7, Tautgirdas Ruzgas1, 2, Johan Engblom1, 2

1 – Department of Biomedical Science, Faculty of Health and Society, Malmö University, SE-205 06 Malmö, Sweden.
2 – Biofilms-Research Center for Biointerfaces (BRCB), Malmö University, SE-205 06 Malmö, Sweden.
3 – Scantox Lund (Timeline Bioresearch AB), Scheelevägen 2, SE-223 63 Lund, Sweden.
4 – Galenica AB, Medeon Science Park, SE-205 12 Malmö, Sweden.
5 – Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, SE-205 02 Malmö, Sweden.
6 – Department of Solid Mechanics & MAX IV Laboratory, Lund University, SE-221 00 Lund, Sweden.
7 – Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden.
8 – Copenhagen Wound Healing Center, Bispebjerg Hospital, Department of Biomedical Sciences, University of Copenhagen, DK-2400 Copenhagen, Denmark.

10.3390/biomedicines9040360pubmed.ncbi.nlm.nih.gov/33807251/wound-healinggottingen-minipig
Behavioral Biology of Pigs and Minipigs2021

Sandra Edwards, Nanna Grand

Book: Behavioral Biology of Laboratory Animals, ISBN: 9780429019517www.taylorfrancis.com/chapters/edit/10.1201/9780429019517-17/behavioral-biology-pigs-minipigs-sandra-edwards-nanna-grand?context=ubx&refId=473a7a55-7628-4173-904a-641631685bdbregulatory-toxicologyothergottingen-minipig
Enhanced Seroconversion to West Nile Virus Proteins in Miceby West Nile Kunjin Replicon Virus-like Particles Expressing Glycoproteins from Crimean–Congo Hemorrhagic Fever Virus2022

Pham-Tue-Hung Tran1, Urban Höglund2, Olivia Larsson2, Sofia Appelberg3, Ali Murazimi4,5, Magnus Johansson1, Wessam Melin1

1 – School of Medical Science, Inflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, 703 62 Örebro, Sweden
2 – Scantox Solna (Adlego Biomedical AB), P.O. Box 42, 751 03 Uppsala, Sweden
3 – Department of Microbiology, Public Health Agency of Sweden, 171 82 Solna, Sweden
4 – Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institution, 141 52 Huddinge, Sweden
5 – National Veterinary Institute, 751 89 Uppsala, Sweden

10.3390/pathogens11020233www.mdpi.com/2076-0817/11/2/233discoveryothermice
Macromolecular Viral Entry Inhibitors as Broad‐SpectrumFirst‐Line Antivirals with Activity against SARS‐CoV‐22022broad‐spectrum antivirals, entry inhibitors, in vivo, macromolecules, polyanions, respiratory syncytial virus (RSV), SARS‐CoV‐2

Rüdiger Groß1, Lívia Mesquita Dias Loiola2,3, Leila Issmail4, Nadja Uhlig4, Valentina Eberlein4, Carina Conzelmann1, Lia‐Raluca Olari1, Lena Rauch1, Jan Lawrenz1, Tatjana Weil1, Janis A. Müller1, Mateus Borba Cardoso3, Andrea Gilg1, Olivia Larsson5, Urban Höglund5, Sandra Axberg Pålsson6, Anna Selch Tvilum2, Kaja Borup Løvschall2, Maria M. Kristensen2, Anna‐Lena Spetz6, Fortune Hontonnou7, Marie Galloux7, Thomas Grunwald4, Alexander N. Zelikin2, Jan Münch1

1 – Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081 Germany
2 – Department of Chemistry and iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus 8000 Denmark
3 – Brazilian Synchrotron Light Laboratory, Brazilian Center for Research in Energy and Materials, Campinas São Paulo, 13083‐970 Brazil
4 – Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig 04103 Germany
5 – Scantox Solna (Adlego Biomedical AB), Solna 171 65 Sweden
6 – Department of Molecular Biosciences, The Wenner‐Gren Institute Stockholm University, Stockholm 10691 Sweden
7 – Université Paris‐Saclay, INRAE, UVSQ, VIM, Jouy‐en‐Josas 78352 France

10.1002/advs.202201378www.ncbi.nlm.nih.gov/pmc/articles/PMC9284172/discoverysars-covmice
A universal SARS-CoV DNA vaccine inducing highlycross-reactive neutralizing antibodies and T cells2022

Sofia Appelberg 1, Gustaf Ahlén2, Jingyi Yan2, Negin Nikouyan2, Sofie Weber3, Olivia Larsson3, Urban Höglund3, Soo Aleman4, Friedemann Weber5, Emma Perlhamre6, Johanna Apro6, Eva‐Karin Gidlund7, Ola Tuvesson7, Simona Salati8, Matteo Cadossi8, Hanna Tegel9, Sophia Hober9, Lars Frelin2, Ali Mirazimi1, and Matti Sällberg2

1 – Public Health Agency of Sweden Solna Sweden
2 – Department of Laboratory Medicine Karolinska Institutet Huddinge Sweden
3 – Scantox Solna (Adlego AB) Uppsala Sweden
4 – Department of Infectious Disease Karolinska University Hospital Huddinge Sweden
5 – Institute for Virology, FB10‐Veterinary Medicine, Justus‐Liebing University Giessen Giessen Germany
6 – Karolinska Trial Alliance Karolinska University Hospital Huddinge Sweden
7 – NorthX Biologics Matfors Sweden
8 – IGEA Bomedical Spa Carpi Italy
9 – Department of Protein Science Royal Institute of Technology Stockholm Sweden

10.15252/emmm.202215821www.embopress.org/doi/full/10.15252/emmm.202215821discoverysars-covmice
Development of a Multivalent Kunjin Virus Reporter Virus-LikeParticle System Inducing Seroconversion for Ebola and West Nile Virus Proteins in Mice2022

Pham-Tue-Hung Tran1, Naveed Asghar1, Urban Höglund2, Olivia Larsson2, Lars Haag3, Ali Mirazimim4,5, Magnus Johansson1, Wessam Melik1

1 – School of Medical Science, Inflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, 703 62 Örebro, Sweden
2 – Scantox Solna (Adlego Biomedical AB), P.O. Box 42, 751 03 Uppsala, Sweden
3 – EM Unit (EMil), Department of Laboratory Medicine, Karolinska Institute, 171 77 Solna, Sweden
4 – Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden
5 – National Veterinary Institute, 751 89 Uppsala, Sweden

10.3390/microorganisms8121890www.mdpi.com/2076-2607/8/12/1890discoveryebolamice
Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-22021antibodies, SARS – CoV – 2, antibody function, antibody binding, spike (S) protein, phagocytosis, in vivo model

Wael Bahnan1, Sebastian Wrighton1, Martin Sundwall1, Anna Läckberg1,2, Olivia Larsson3, Urban Höglund3, Hamed Khakzad4,5, Magdalena Godzwon6, Maria Walle6, Elisabeth Elder7, Anna Söderlund Strand8, Lotta Happonen1, Oscar André1, Johannes Kumra Ahnlide1, Thoms Hellmark9, Vidar Wendel-Hansen10, Robert P.A. Wallin11, Johan Malmström1, Lars Malmström1,12, Mats Ohlin6,13, Magnus Rasmussen1,2, Pontus Nordenfelt1

1 – Department of Clinical Sciences Lund, Infection Medicine, Faculty of Medicine, Lund University, Lund, Sweden
2 – Infectious Disease Clinic, Skåne University Hospital, Lund, Sweden
3 – Scantox Solna (Adlego Biomedical AB), Uppsala, Sweden
4 – Equipe Signalisation Calcique et Infections Microbiennes, Ecole Normale Supérieure Paris-Saclay, Gif-sur-Yvette, France
5 – Institut National de la Santé et de la Recherche Médicale (INSERM) U1282, Gif-sur-Yvette, France
6 – Department of Immunotechnology, Lund University, Lund, Sweden
7 – Public Health Agency of Sweden, Solna, Sweden
8 – Department of Laboratory Medicine, Clinical Microbiology, Skane University Hospital Lund, Lund University, Lund, Sweden
9 – Department of Clinical Sciences Lund, Nephrology, Skane University Hospital Lund, Lund University, Lund, Sweden
10 – Tanea Medical Ab, Uppsala, Sweden
11 – SciEd Solutions, Stockholm, Sweden
12 – Institute for Computational Science, Zurich, Switzerland
13 – SciLifeLab Drug Discovery and Development, Lund University, Lund, Sweden

10.3389/fimmu.2021.808932www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.808932/fullsars-covmice
The Non-Human Primate in Safety Assessment of aBifunctional Long-Acting Insulin Analogue2023non-clinical development, non-human primates, minipigs, cynomolgus monkey, safety assessment, long-acting insulin, PCSK9i

Vivi FH Jensen DVM PhD1, Nikolai K Jensen DVM1, Line H Schefe PhD1, Jens Sigh PhD1, Akiyemi Akintomide MSc2, Kari Kaaber DVM3, Sophia G Moesgaard DVM PhD4, Mona H Pedersen PhD1

1 – Global Drug Discovery and Development Sciences, Novo Nordisk A/S, Maaloev, Denmark
2 – Labcorp Early Development Laboratories Limited, Huntingdon, UK
3 – Scantox A/S, Lille Skensved, Denmark
4 – Y-mAbs Therapeutics A/S, Hørsholm, Denmark

10.1177/10915818231156898journals.sagepub.com/doi/10.1177/10915818231156898regulatory-toxicologyotherother
Alginate and Nanocellulose Dressings With Extract FromSalmon Roe Reduce Inflammation and Accelerate Healing of Porcine Burn Wounds2023Anti-inflammatory agents, oxidative stress, inflammation, alginates, bandages, burns, interleukins, macrophages, salmon, suidae, swine, miniature, wound healing, dressing of skin or wounds, inflammatory response, partial thickness burns

Karin M Gilljam PhD, Patrik Stenlund PhD, Simon Standort MSc, Sisse Bindslev Andersen DVM,
Kari Kaaber DVM, Henrik Lund MD PhD, Karl R K Bryn MD

10.1093/jbcr/irad006academic.oup.com/jbcr/article/44/5/1140/6987519?login=falsediscoverywound-healinggottingen-minipig
Subclass-switched anti-spike IgG3 oligoclonal cocktailsstrongly enhance Fc-mediated opsonization2023Fc-mediated function; affinity; oligoclonal; phagocytosis; subclass

Arman Izadi1, Arsema Hailu1, Magdalena Godwon2, Sebastian Wrighton1, Berit Olofsson1, Tobias Schmidt3,4, Anna Söderlund-Strand5, Elizabeth Elder6, Sofia Appelberg7, Maria Valsjö8, Olivia Larsson8, Vidar Wendel-Hansen9, Mats Ohlin2,10, Wael Bahnan1, Pontus Nordenfelt1,5.

1 – Department of Clinical Sciences Lund, Division of Infection Medicine, Faculty of Medicine, Lund University, 221 84 Lund, Sweden.
2 – Department of Immunotechnology, Faculty of Engineering, Lund University, 221 00 Lund, Sweden.
3 – Department of Clinical Sciences Lund, Division of Pediatrics, Faculty of Medicine, Lund University, 221 84 Lund, Sweden.
4 – Wallenberg Center for Molecular Medicine, Faculty of Medicine, Lund University, 221 84 Lund, Sweden.
5 – Department of Laboratory Medicine, Clinical Microbiology, Skåne University Hospital Lund, Lund University, 221 85 Lund, Sweden.
6 – Department of Microbiology, National Veterinary Institute, 751 89 Uppsala, Sweden.
7 – Department of Microbiology, Public Health Agency of Sweden, 171 82 Stockholm, Sweden.
8 – Scantox A/S, 171 65 Stockholm, Sweden.
9 – Tanea Medical AB, 751 83 Uppsala, Sweden.
10 – SciLifeLab Drug Discovery and Development, Lund University, 221 00 Lund, Sweden.

pubmed.ncbi.nlm.nih.gov/37011197/discovery
Iodine loaded nanoparticles with commercial applicabilityincrease survival in mice cancer models with low degree of side effects2023cytotoxic; drug delivery; molecular iodine; nanoparticles; side effects.

Torkel Falkenberg, Olivia Larsson, Bengt Hedin, Shigeru Shiraki, Takahisa Karita

10.1002/cnr2.1843pubmed.ncbi.nlm.nih.gov/37269144/discoverycancermice
First virological and pathological study of Göttingen Minipigswith Dippity Pig Syndrome (DPS)2023

Hina Jhelum, Nanna Grand, Kirsten Rosenmay Jacobsen, Sabrina Halecker, Michelle Salerno, Robert Prate, Luise Krüger, Yannick Kristiansen, Ludwig Krabben, Lars Möller, Michael Laue, Benedikt Kaufer, Kari Kaaber, Joachim Denner

Laboratory of Joachim Denner at the Robert Koch Institute and the Institute of Virology was supported by the Deutsche Forschungsgemeinschaft, TRR127.

10.1371/journal.pone.0281521journals.plos.org/plosone/article?id=10.1371/journal.pone.0281521regulatory-toxicologyothergottingen-minipig
Comparison of efficacy between subcutaneous andintravenous application of moss-aGal in the mouse model of Fabry disease2023enzyme replacement therapy, Fabry disease, moss-aGal, subcutaneous application

Paulina Dabrowska-Schlepp1, Andreas Busch1, Jin-Song Shen2, Rachel Y. Cheong3, Lone Bruhn Madsen3,
Daniel Mascher4, Raphael Schiffmann2, Andreas Schlaaf1

1 – Eleva GmbH, Freiburg, Germany
2 – Institute of Metabolic Disease, Baylor, Scott & White Research Institute, Dallas, Texas, USA
3 – Scantox Sweden (Previously Timeline Bioresearch AB), Lund, Sweden
4 – pharm-analyt Labor GmbH, Baden, Austria

10.1002/jmd2.12393scantox.com/wp-content/uploads/2023/09/JIMD-Reports-2023-DabrowskaSchlepp.pdfdiscoveryothermice