Gene Expression Analysis of FMR1-KO Mouse Caudate Putamen Reveals New Preclinical Biomarkers for Fragile X Syndrome

Authors

Shirin Sharghi ^1,2Stefanie Flunkert ³Magdalena Daurer ¹Livia Breznik ¹Boris Philippe Chagnaud ²Manuela Prokesch ^1*

Affiliations

1. Scantox Neuro GmbH, Grambach, Austria
2. Institute for Biology, Karl-Franzens University of Graz, Graz, Austria
3. BioDoks e. U.. St. Georgen an der Stiefing, Austria

Access the publication

https://www.frontiersin.org/articles/10.3389/fnins.2026.1833413

General info

Year: 2026
Division: Discovery
Disease: Autism spectrum disorder
Model: Fmr1-KO mice
Material: Publication
DOI: 10.3389/fnins.2026.1833413
Keywords: Fragile X syndrome (FXS), Fmr1-KO mouse, RNA sequencing, caudate putamen, transcriptomics, neurodevelopmental disorder, autism spectrum disorder (ASD), biomarker discovery, necdin (NDN), insulin degrading enzyme (IDE)