Escaping the cohort of concern: in vitro experimental evidence supports non‑mutagenicity of N‑nitroso‑hydrochlorothiazide

Authors

R.D. Gandhi¹, S. Hickert², Y. Hoevelmann², C.D. Mee³, J. Schlingemann², A. Adams⁵, A. Blanazs⁵, S. Simon², J. Elloway¹, L. Rigger⁴, A. Teasdale⁵, C.V. Beaumont¹, L. Wright⁶, A. Doherty¹

Affiliations

1 Safety Sciences, R&D, AstraZeneca, Cambridge, UK
2 Merck KGaA, Darmstadt, Germany
3 Gentronix Ltd. Alderley Park, Macclesfield, UK
4 Reference Materials R&D, Merck KGaA, Buchs, Switzerland
5 Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, UK
6 Safety Sciences, R&D, AstraZeneca, Macclesfield, UK

Access the publication

https://link.springer.com/epdf/10.1007/s00204-024-03859-3?sharing_token=r0sE8LYepYWcX_slQX23Mve4RwlQNchNByi7wbcMAY7FVqqnvPpY2N0LVdAvWGHnKHuz7yOGl-c4sPVu242ImxV4MyUbQ9QnlxomQRw_BdoWlb2K1I1VP7VclVnO5G6PlPFRaC-rQoK746ypWoA3u3bzZC6yA7odaQeDOJThz38%3D

General info

Year: 2024
Division: Genetic Toxicology
Model: Other
Material: Publication
DOI: 10.1007/s00204-024-03859-3
Keywords: Nitrosamine · Ames · HCTZ · Mutagenic · Genotoxic · Impurity