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APP Transgenic Mouse Models

Alzheimer’s disease (AD) is one of the most devastating neurodegenerative diseases of the 21st century. A disturbed APP metabolism (e.g. pathological aggregation of amyloid) in the brain of AD patients is thought to be one of the main causes of the observed progressive cognitive decline in affected people. The development of new AD drugs targeting APP related mechanisms is therefore one main focus in AD research. To be able to test these new drugs, appropriate animal models are needed.

Scantox currently offers several human APP transgenic mouse lines featuring different properties with regard to Aβ expression patternsneuroinflammationcognitive deficitsage at onset and progression of pathology. These animals focus on different pathological readouts and constitute suitable models to study the influence of drugs on APP-related brain pathology and behavior.

Scantox offers custom tailored study design for these models and we are flexible to accommodate to your special interests. We are also happy to advice you and propose study designs. Scantox maintains its own colonies directly in our research facility. Non-transgenic littermates are available as control animals needed for proper study design.

We would be happy to test your compounds in these mouse models! Readouts depend on model but the most common are:

  • Aβ-38,-40 and -42 levels
  • Aggregated Amyloid levels by A4 Assay
  • Plaque load
  • β-sheet load
  • pE(3)-Aβ load
  • Neurofilament Light Chain levels
  • Neuronal loss
  • Synaptic alterations
  • Oxidative stress
  • Neuroinflammation
  • Cerebral vascular angiopathy (CAA)
  • Phosphorylated tau
  • Blood brain barrier homeostasis
  • Learning and memory deficits (MWM)

Looking for something else? Please contact us!

You might be also interested in these related models:

As with all other in vivo models we are also ready to provide samples (brain tissue, CSF etc.) from these animals for analyses in your laboratory.

We are happy to receive your inquiry.

In vitro Services

Scantox provides research services with numerous standardized cell culture systems including transgenic and non-transgenic cell lines, glial cells, primary chicken and rat peripheral and central nervous system neurons of different development stages and organotypic brain slices. New models are developed and validated on request.
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General Toxicology

Scantox offers general toxicology studies in both rodents and a non-rodents, and all technical staff are highly experienced and experts in handling and dosing of animals. Within the field of minipig toxicology Scantox is globally considered the leading expert.
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From the corporate headquarters in Denmark and subsidiaries in Europe, Scantox is today serving customers all over the world. Scantox is world known for high quality data, on time deliveries, and high ethical standards.
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Let Scantox be the next step in your professional career! We are always looking for new talent, and we currently have a number of open positions at our sites. We also always welcome unsolicited applications, so don’t hesitate to get in touch if you would like to join a team great team!
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