Scientific References – Publications
Scantox encourages its scientists to publish and disseminate the results of their high quality research which is mostly done in close collaboration with our clients.
Title | Year | Scantox Business Unit | Disease | Model | Keywords | Authors | Affiliations | Analysis method | Biomarker | Tissue | DOI | More details | hf:tax:division | hf:tax:disease | hf:tax:model | hf:tax:tissue |
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Probing Skin Barrier Recovery on Molecular Level Following Acute Wounds: An In Vivo/Ex Vivo Study on Pigs | 2021 | Discovery | Wound Healing | Göttingen Minipig | Enamul Haque Mojumdar 1,2, Lone Bruhn Madsen3, Henri Hansson4, Ida Taavoniku3, Klaus Kristensen3, | 1 – Department of Biomedical Science, Faculty of Health and Society, Malmö University, SE-205 06 Malmö, Sweden. | 10.3390/biomedicines9040360 | pubmed.ncbi.nlm.nih.gov/33807251/ | discovery | wound-healing | gottingen-minipig | |||||
Behavioral Biology of Pigs and Minipigs | 2021 | Regulatory Toxicology | Other | Göttingen Minipig | Sandra Edwards, Nanna Grand | Book: Behavioral Biology of Laboratory Animals, ISBN: 9780429019517 | www.taylorfrancis.com/chapters/edit/10.1201/9780429019517-17/behavioral-biology-pigs-minipigs-sandra-edwards-nanna-grand?context=ubx&refId=473a7a55-7628-4173-904a-641631685bdb | regulatory-toxicology | other | gottingen-minipig | ||||||
Enhanced Seroconversion to West Nile Virus Proteins in Mice by West Nile Kunjin Replicon Virus-like Particles Expressing Glycoproteins from Crimean–Congo Hemorrhagic Fever Virus | 2018 | Discovery | Other | Mice | Pham-Tue-Hung Tran1, Urban Höglund2, Olivia Larsson2, Sofia Appelberg3, Ali Murazimi4,5, Magnus Johansson1, | 1 – School of Medical Science, Inflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, 703 62 Örebro, Sweden | 10.3390/pathogens11020233 | www.mdpi.com/2076-0817/11/2/233 | discovery | other | mice | |||||
Macromolecular Viral Entry Inhibitors as Broad‐Spectrum First‐Line Antivirals with Activity against SARS‐CoV‐2 | 2019 | Discovery | SARS-CoV | Mice | Rüdiger Groß1, Lívia Mesquita Dias Loiola2,3, Leila Issmail4, Nadja Uhlig4, Valentina Eberlein4, Carina Conzelmann1, Lia‐Raluca Olari1, Lena Rauch1, Jan Lawrenz1, Tatjana Weil1, Janis A. Müller1, Mateus Borba Cardoso3, Andrea Gilg1, Olivia Larsson5, Urban Höglund5, Sandra Axberg Pålsson6, Anna Selch Tvilum2, Kaja Borup Løvschall2, Maria M. Kristensen2, Anna‐Lena Spetz6, Fortune Hontonnou7, Marie Galloux7, Thomas Grunwald4, Alexander N. Zelikin2, Jan Münch1 | 1 – Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081 Germany | 10.1002/advs.202201378 | www.ncbi.nlm.nih.gov/pmc/articles/PMC9284172/ | discovery | sars-cov | mice | |||||
A universal SARS-CoV DNA vaccine inducing highly cross-reactive neutralizing antibodies and T cells | 2024 | Discovery | SARS-CoV | Mice | Sofia Appelberg 1, Gustaf Ahlén2, Jingyi Yan2, Negin Nikouyan2, Sofie Weber3, Olivia Larsson3, Urban Höglund3, | 1 – Public Health Agency of Sweden Solna Sweden | 10.15252/emmm.202215821 | www.embopress.org/doi/full/10.15252/emmm.202215821 | discovery | sars-cov | mice | |||||
Development of a Multivalent Kunjin Virus Reporter Virus-Like Particle System Inducing Seroconversion for Ebola and West Nile Virus Proteins in Mice | 2022 | Discovery | Ebola | Mice | Pham-Tue-Hung Tran1, Naveed Asghar1, Urban Höglund2, Olivia Larsson2, Lars Haag3, Ali Mirazimim4,5, | 1 – School of Medical Science, Inflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, 703 62 Örebro, Sweden | 10.3390/microorganisms8121890 | www.mdpi.com/2076-2607/8/12/1890 | discovery | ebola | mice | |||||
Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2 | 2021 | Discovery | SARS-CoV | Mice | Wael Bahnan, Sebastian Wrighton, martin Sundwall, Anna läckberg, Olivia Larsson, Urban Höglund, Hamed Khakzad, Magdalena Godzwon, Maria Walle, Elisabeth Elder, Anna Söderlund Strand, Lotta Happonen, Oscar André, Johannes Kumra Ahnlide, Thoms Hellmark, Vidar Wendel-Hansen, Robert PS Wallin, Johan Malmström, lars Malmström, Mats Ohlin, Magnus Rasmussen, Pontus Nordenfelt | 10.3389/fimmu.2021.808932 | www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.808932/full | discovery | sars-cov | mice | ||||||
The Non-Human Primate in Safety Assessment of a Bifunctional Long-Acting Insulin Analogue | 2023 | Regulatory Toxicology | Other | Other | non-clinical development, non-human primates, minipigs, cynomolgus monkey, safety assessment, long-acting insulin, PCSK9i | Vivi FH Jensen DVM PhD1, Nikolai K Jensen DVM1, Line H Schefe PhD1, Jens Sigh PhD1, Akiyemi Akintomide MSc2, | 1 – Global Drug Discovery and Development Sciences, Novo Nordisk A/S, Maaloev, Denmark | 10.1177/10915818231156898 | journals.sagepub.com/doi/10.1177/10915818231156898 | regulatory-toxicology | other | other | ||||
Alginate and Nanocellulose Dressings With Extract From Salmon Roe Reduce Inflammation and Accelerate Healing of Porcine Burn Wounds | 2023 | Discovery | Wound Healing | Göttingen Minipig | Anti-inflammatory agents, oxidative stress, inflammation, alginates, bandages, burns, interleukins, macrophages, salmon, suidae, swine, miniature, wound healing, dressing of skin or wounds, inflammatory response, partial thickness burns | Karin M Gilljam PhD, Patrik Stenlund PhD, Simon Standort MSc, Sisse Bindslev Andersen DVM, | 10.1093/jbcr/irad006 | academic.oup.com/jbcr/article/44/5/1140/6987519?login=false | discovery | wound-healing | gottingen-minipig | |||||
Subclass-switched anti-spike IgG3 oligoclonal cocktails strongly enhance Fc-mediated opsonization | 2023 | Discovery | SARS-CoV | Mice | Fc-mediated function; affinity; oligoclonal; phagocytosis; subclass | Arman Izadi1, Arsema Hailu1, Magdalena Godwon2, Sebastian Wrighton1, Berit Olofsson1, Tobias Schmidt3,4, Anna Söderlund-Strand5, Elizabeth Elder6, Sofia Appelberg7, Maria Valsjö8, Olivia Larsson8, Vidar Wendel-Hansen9, Mats Ohlin2,10, Wael Bahnan1, Pontus Nordenfelt1,5. | 1 – Department of Clinical Sciences Lund, Division of Infection Medicine, Faculty of Medicine, Lund University, 221 84 Lund, Sweden. | 10.1073/pnas.2217590120 | pubmed.ncbi.nlm.nih.gov/37011197/ | discovery | sars-cov | mice | ||||
Iodine loaded nanoparticles with commercial applicability increase survival in mice cancer models with low degree of side effects | 2024 | Discovery | Cancer | Mice | cytotoxic; drug delivery; molecular iodine; nanoparticles; side effects. | Torkel Falkenberg, Olivia Larsson, Bengt Hedin, Shigeru Shiraki, Takahisa Karita | 10.1002/cnr2.1843 | pubmed.ncbi.nlm.nih.gov/37269144/ | discovery | cancer | mice | |||||
"First virological and pathological study of Göttingen Minipigs with Dippity Pig Syndrome (DPS)" | 2023 | Regulatory Toxicology | Dippity Pig Syndrome | Göttingen Minipig | Hina Jhelum, Nanna Grand, Kirsten Rosenmay Jacobsen, Sabrina Halecker, Michelle Salerno, Robert Prate, Luise Krüger, Yannick Kristiansen, Ludwig Krabben, Lars Möller, Michael Laue, Benedikt Kaufer, Kari Kaaber, Joachim Denner | Laboratory of Joachim Denner at the Robert Koch Institute and the | 10.1371/journal.pone.0281521 | journals.plos.org/plosone/article?id=10.1371/journal.pone.0281521 | regulatory-toxicology | dippity-pig-syndrome | gottingen-minipig | |||||
Comparison of efficacy between subcutaneous and intravenous application of moss-aGal in the mouse model of Fabry disease | 2023 | Discovery | Fabry disease | Mice | enzyme replacement therapy, Fabry disease, moss-aGal, subcutaneous application | Paulina Dabrowska-Schlepp1, Andreas Busch1, Jin-Song Shen2, Rachel Y. Cheong3, Lone Bruhn Madsen3, Daniel Mascher4, Raphael Schiffmann2, Andreas Schlaaf1 | 1 – Eleva GmbH, Freiburg, Germany | 10.1002/jmd2.12393 | scantox.com/wp-content/uploads/2023/09/JIMD-Reports-2023-DabrowskaSchlepp.pdf | discovery | fabry-disease | mice | ||||
Plasma pharmacokinetic and metabolism of [18F]THK-5317 are dependent on sex | 2023 | Discovery | Rats | (S)-[(18)F]THK-5117; Metabolism; Pharmacokinetic; Sex-dependent; [(18)F]THK-5317. | Severin Mairinger 1, Thomas Filip 1, Michael Sauberer 1, Stefanie Flunkert 2, Thomas Wanek 1, Johann Stanek 1, Sara Furtner 1, Birgit Hutter-Paier 2, Nobuyuki Okamura 3, Claudia Kuntner 4 | 1 – Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, 2444 Seibersdorf, Austria. | 10.1016/j.nucmedbio.2020.01.001 | pubmed.ncbi.nlm.nih.gov/31981857/ | discovery | rats | ||||||
Characterization of the visceral and neuronal phenotype of 4L/PS-NA mice modeling Gaucher disease. | 2020 | Discovery | Gaucher disease | 4L/PS-NA mice, Mice | Victoria Schiffer 1, Estibaliz Santiago-Mujika 1, Stefanie Flunkert 1, Staffan Schmidt 2, Martina Farcher 1, Tina Loeffler 1, Irene Schilcher 1, Maria Posch 1, Joerg Neddens 1, Ying Sun 3 4, Jan Kehr 2, Birgit Hutter-Paier 1 | 1 – QPS Austria GmbH, Neuropharmacology, Grambach, Austria. | 10.1371/journal.pone.0227077 | pubmed.ncbi.nlm.nih.gov/31929594/ | discovery | gaucher-disease | 4l-ps-na-mice mice | |||||
Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer’s-like mice. | 2020 | Discovery | AD | APPSLxhQC | APPSWE/PS1ΔE9; Immunotherapy; Microhemorrhage; Phagocytosis; Pyroglutamate-3 amyloid-β; microPET. | Helen Crehan 1 2, Bin Liu 1 2, Martin Kleinschmidt 3 4, Jens-Ulrich Rahfeld 3 4, Kevin X Le 1, Barbara J Caldarone 2 5, Jeffrey L Frost 1, Thore Hettmann 3, Birgit Hutter-Paier 6, Brian O’Nuallain 1 2, Mi-Ae Park 2 7, Marcelo F DiCarli 2 7, Inge Lues 3, Stephan Schilling 3 4, Cynthia A Lemere 8 9 | 1 – Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Hale BTM 9002S, 60 Fenwood Rd, Boston, MA, 02115, USA. | 10.1186/s13195-019-0579-8 | pubmed.ncbi.nlm.nih.gov/31931873/ | discovery | ad | appslxhqc | ||||
The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies | 2020 | Discovery | Lewy body dementia, PD | D-Line mice, Human | Leukotrienes; Montelukast; alpha-synulcein; autophagy; cognition; dementia; neuroinflammation. | Julia Marschallinger # 1 2, Barbara Altendorfer # 1 2, Edward Rockenstein 3, Miriam Holztrattner 1 2, Julia Garnweidner-Raith 1 2, Nadine Pillichshammer 1 2, Iris Leister 1 2, Birgit Hutter-Paier 4, Katharina Strempfl 1 2 4, Michael S Unger 1 2, Mansoor Chishty 5, Thomas Felder 6, Mary Johnson 7, Johannes Attems 7, Eliezer Masliah 3, Ludwig Aigner 8 9 10 | 1 – Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria. | 10.1007/s13311-020-00836-3 | pubmed.ncbi.nlm.nih.gov/32072462/ | discovery | lewy-body-dementia pd | d-line-mice human | ||||
Transgene integration causes RARB downregulation in homozygous Tg4-42 mice | 2020 | Discovery | AD | Tg4-42 mice | Barbara Hinteregger 1 2, Tina Loeffler 1, Stefanie Flunkert 3, Joerg Neddens 1, Ruth Birner-Gruenberger 2 4 5 6, Thomas A Bayer 7, Tobias Madl 2 5, Birgit Hutter-Paier 1 | 1 – QPS Austria GmbH, Parkring 12, 8074, Grambach, Austria. | 10.1038/s41598-020-63512-8 | pubmed.ncbi.nlm.nih.gov/32286473/ | discovery | ad | tg4-42-mice | |||||
CD8+ T-cells infiltrate Alzheimer's disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice | 2020 | Discovery | AD | APP/PS1 mice, Mice | Alzheimer’s disease; Arc; CD8(+) T-cells; Npas4; RNAseq; Synapse. | M S Unger 1, E Li 1, L Scharnagl 1, R Poupardin 2, B Altendorfer 1, H Mrowetz 1, B Hutter-Paier 3, T M Weiger 4, M T Heneka 5, J Attems 6, L Aigner 7 | “1 – Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria. | Alzheimer’s disease; Arc; CD8(+) T-cells; Npas4; RNAseq; Synapse. | pubmed.ncbi.nlm.nih.gov/32479993/ | discovery | ad | app-ps1-mice mice | ||||
Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value | 2020 | Discovery | AD, ALS, Gaucher disease, PD | 4L/PS-NA mice, 5xFAD mice, Line 61 mice, SOD1-G93A mice, TAR6/6 mice | Neurofilament-light chain; animal model; biomarker; cerebrospinal fluid; lysosomal storage diseases; neurodegenerative disease; plasma; preclinical research. | Tina Loeffler 1, Irene Schilcher 1, Stefanie Flunkert 1, Birgit Hutter-Paier 1 | 1 – Neuropharmacology, QPS Austria GmbH, Grambach, Austria. | 10.3389/fnins.2020.00579 | pubmed.ncbi.nlm.nih.gov/32595447/ | discovery | ad als gaucher-disease pd | 4l-ps-na-mice 5xfad-mice line-61-mice sod1-g93a-mice tar6-6-mice | ||||
Validation of behavioral phenotypes in the BACHD rat model | 2020 | Discovery | HD | BACHD rats, Rats | BACHD rats; Behavioral phenotype validation; Behavioral phenotyping. | Arianna Novati 1, Giuseppe Manfré 2, Stefanie Flunkert 3, Johanneke E Van der Harst 4, Judith R Homberg 5, Robert Wronski 3, Huu Phuc Nguyen 6 | 1 – Institute of Medical Genetics and Applied Genomics, University of Tübingen, Calwerstrasse7, 72076, Tübingen, Germany; Centre for Rare Diseases, University of Tübingen, Calwerstrasse7, 72076, Tübingen, Germany; QPS Austria GmbH, Neuropharmacology, Parkring 12, 8074, Grambach, Austria; Department of Human Genetics, Ruhr University Bochum, Universitätsstraße 150, 44801, Bochum, Germany. | 10.1016/j.bbr.2020.112783 | pubmed.ncbi.nlm.nih.gov/32574646/ | discovery | hd | bachd-rats rats | ||||
Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer's disease and related murine models | 2020 | Discovery | AD | 5xFAD mice, APPSL mice, Human, Mice | Joerg Neddens 1, Magdalena Daurer 1, Stefanie Flunkert 1, Kerstin Beutl 1 2, Tina Loeffler 1, Lauren Walker 3, Johannes Attems 3, Birgit Hutter-Paier 1 | 1 – QPS Austria GmbH, Grambach, Austria. | 10.1371/journal.pone.0235543 | www.ncbi.nlm.nih.gov/pmc/articles/PMC7347153/ | discovery | ad | 5xfad-mice appsl-mice human mice | |||||
Constant Levels of Tau Phosphorylation in the Brain of htau Mice | 2020 | Discovery | AD, Tauopathies | htau mice, Mice | Alzheimer’s disease; genetic background; human tau; immunofluorescent labelling; mouse model; phosphorylation; progression; tauopathies. | Joerg Neddens 1, Magdalena Daurer 1, Tina Loeffler 1, Saioa Alzola Aldamizetxebarria 1, Stefanie Flunkert 1, Birgit Hutter-Paier 1 | 1 – QPS Austria GmbH, Grambach, Austria. | 10.3389/fnmol.2020.00136 | pubmed.ncbi.nlm.nih.gov/32982685/ | discovery | ad tauopathies | htau-mice mice | ||||
Improved Bioavailability of Montelukast through a Novel Oral Mucoadhesive Film in Humans and Mice | 2020 | AD | C57BL6 mice, Human | Alzheimer’s disease; dementia; drug delivery; montelukast. | Johanna Michael 1, Diana Bessa de Sousa 1, Justin Conway 2, Erick Gonzalez-Labrada 2, Rodolphe Obeid 2, Julia Tevini 3, Thomas Felder 3, Birgit Hutter-Paier 4, Horst Zerbe 2, Nadine Paiement 2, Ludwig Aigner 1 4 5 | 1 – Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria. | 10.3390/pharmaceutics13010012 | www.ncbi.nlm.nih.gov/pmc/articles/PMC7822410/ | ad | c57bl6-mice human | ||||||
Quantification of Huntington’s Disease Related Markers in the R6/2 Mouse Model | 2021 | Discovery | HD | Mice, R6/2 mice | Ctip2; Huntington animal model; TSPO; histological evaluation; quantification. | Estibaliz Etxeberria-Rekalde 1, Saioa Alzola-Aldamizetxebarria 1, Stefanie Flunkert 1, Isabella Hable 1 2, Magdalena Daurer 1, Joerg Neddens 1, Birgit Hutter-Paier 1 | 1- QPS Austria GmbH, Grambach, Austria. | 10.3389/fnmol.2020.617229 | www.ncbi.nlm.nih.gov/pmc/articles/PMC7831778/ | discovery | hd | mice r6-2-mice | ||||
Bispecific Tau Antibodies with Additional Binding to C1q or Alpha-Synuclein | 2021 | Discovery | AD, Tauopathies | Human | Alpha-synuclein; Alzheimer’s disease; C1q; immunotherapy; synucleinopathies; tau; tauopathies. | Wim Hendricus Quint 1, Irena Matečko-Burmann 2 3, Irene Schilcher 4, Tina Löffler 4, Michael Schöll 2 3 5, Björn Marcus Burmann 2 6, Thomas Vogels 1 3 5 | 1 – Maptimmune BV, The Hague, The Netherlands. | 10.3233/JAD-201334 | pubmed.ncbi.nlm.nih.gov/33579845/ | discovery | ad tauopathies | human | ||||
Homozygosity of BACHD rats not only causes strong behavioral deficits in young female rats but also a reduced breeding success | 2021 | Discovery | HD | BACHD rats, Rats | Behavioral analysis; Breeding success; Homozygosity; Huntington’s disease; Learning and memory; Sex differences. | Stephan Kurat, Petra Heinrich, Agnes Molnar-Kasza, Tina Loeffler, Stefanie Flunkert, Birgit Hutter-Paier | QPS Austria GmbH, Neuropharmacology, Parkring 12, 8074 Grambach, Austria. | 10.1016/j.brainres.2021.147396 | pubmed.ncbi.nlm.nih.gov/33662341/ | discovery | hd | bachd-rats rats | ||||
The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice | 2021 | Discovery | AD | 5xFAD mice, Mice | 5xFAD; Alzheimer’s disease; RNAseq; cognition; cysteinyl leukotrienes; leukotriene receptor antagonist; microglia; montelukast. | Johanna Michael 1 2, Julia Zirknitzer 1 2, Michael Stefan Unger 1 2, Rodolphe Poupardin 2, Tanja Rieß 1 2, Nadine Paiement 3, Horst Zerbe 3, Birgit Hutter-Paier 4, Herbert Reitsamer 5, Ludwig Aigner 1 2 6 | 1 – Institute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria. | 10.3390/ijms22052782 | www.ncbi.nlm.nih.gov/pmc/articles/PMC7967180/ | discovery | ad | 5xfad-mice mice | ||||
Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer's Disease | 2021 | Discovery | AD | Mice, Tg4-42 mice | Alzheimer’s disease; behavior; biomarkers; neuroinflammation; neuronal degeneration; nuclear magnetic resonance. | Barbara Hinteregger 1 2, Tina Loeffler 1, Stefanie Flunkert 1, Joerg Neddens 1, Thomas A Bayer 3, Tobias Madl 2 4, Birgit Hutter-Paier 1 | 1 – QPS Austria GmbH, Grambach, Austria. | 10.3233/JAD-201204 | www.ncbi.nlm.nih.gov/pmc/articles/PMC8150512/ | discovery | ad | mice tg4-42-mice | ||||
Evaluation of Neuropathological Features in the SOD1-G93A Low Copy Number Transgenic Mouse Model of Amyotrophic Lateral Sclerosis | 2021 | Discovery | ALS | Mice, SOD1-G93A mice | neuroinflammation, muscle phenotype, spinal cord, survival rate, muscle strength, body weight | Agnes Molnar-Kasza 1, Barbara Hinteregger 1, Joerg Neddens 1, Roland Rabl 1, Stefanie Flunkert 1, Birgit Hutter-Paier 1 | 1 – QPS Austria GmbH, Grambach, Austria. | 10.3389/fnmol.2021.681868 | pubmed.ncbi.nlm.nih.gov/34248499/ | discovery | als | mice sod1-g93a-mice | ||||
Characterization of an APP/tau rat model of Alzheimer's disease by positron emission tomography and immunofluorescent labeling | 2021 | Discovery | AD | APP/tau rats, Rats | Alzheimer’s disease; Immunohistochemistry; Rat model; [11C]PiB; [18F]THK-5317. | Thomas Filip 1 2, Severin Mairinger 1 3, Joerg Neddens 4, Michael Sauberer 1 5, Stefanie Flunkert 4, Johann Stanek 1 5, Thomas Wanek 1 5, Nobuyuki Okamura 6, Oliver Langer 1 3 5, Birgit Hutter-Paier 4, Claudia Kuntner 7 8 | 1 – Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, 2444, Seibersdorf, Austria. | 10.1186/s13195-021-00916-2 | www.ncbi.nlm.nih.gov/pmc/articles/PMC8522096/ | discovery | ad | app-tau-rats rats | ||||
CD4+ T cells contribute to neurodegeneration in Lewy body dementia | 2021 | Discovery | AD, Lewy body dementia | Human | David Gate 1 2 3, Emma Tapp 2 3, Olivia Leventhal 2 3, Marian Shahid 2, Tim J Nonninger 2 3, Andrew C Yang 4 5, Katharina Strempfl 6 7 8, Michael S Unger 6 7, Tobias Fehlmann 9, Hamilton Oh 2 3, Divya Channappa 2, Victor W Henderson 2, Andreas Keller 2 9, Ludwig Aigner 6 7, Douglas R Galasko 10, Mark M Davis 11 12, Kathleen L Poston 2, Tony Wyss-Coray 2 3 5 | 1 – Department of Neurology, Northwestern University, Chicago, IL, USA. | 10.1126/science.abf7266 | www.ncbi.nlm.nih.gov/pmc/articles/PMC9122025/ | discovery | ad lewy-body-dementia | human | |||||
A brain proteomic signature of incipient Alzheimer's disease in young APOE ε4 carriers identifies novel drug targets | 2021 | Discovery | AD | Human | Alzheimer’s disease; anti-pyroglutamyl β-amyloid antibody; drug combination; glutaminyl cyclase inhibitor; hAPPsl×hQC mice; immunotherapy | Jackson A Roberts 1 2, Vijay R Varma 1, Yang An 3, Sudhir Varma 4, Julián Candia 5 6, Giovanna Fantoni 7, Vinod Tiwari 8, Carlos Anerillas 9, Andrew Williamson 1, Atsushi Saito 10, Tina Loeffler 11, Irene Schilcher 11, Ruin Moaddel 12, Mohammed Khadeer 12, Jacqueline Lovett 12, Toshiko Tanaka 6, Olga Pletnikova 10 13, Juan C Troncoso 10 14, David A Bennett 15, Marilyn S Albert 14, Kaiwen Yu 16, Mingming Niu 16, Vahram Haroutunian 17 18, Bin Zhang 19, Junmin Peng 16, Deborah L Croteau 8, Susan M Resnick 3, Myriam Gorospe 9, Vilhelm A Bohr 8, Luigi Ferrucci 6, Madhav Thambisetty 1 | 1 – Clinical and Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. | 10.1126/sciadv.abi8178 | www.ncbi.nlm.nih.gov/pmc/articles/PMC8580310/ | discovery | ad | human | ||||
Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mice | 2021 | Discovery | AD | APPxhQC mice, Mice | Alzheimer’s disease; anti-pyroglutamyl β-amyloid antibody; drug combination; glutaminyl cyclase inhibitor; hAPPsl×hQC mice; immunotherapy. | Torsten Hoffmann 1, Jens-Ulrich Rahfeld 2, Mathias Schenk 2, Falk Ponath 3, Koki Makioka 3, Birgit Hutter-Paier 4, Inge Lues 1, Cynthia A Lemere 3, Stephan Schilling 2 5 | 1 – Vivoryon Therapeutics N.V., Weinbergweg 22, 06120 Halle, Germany. | 10.3390/ijms222111791 | www.ncbi.nlm.nih.gov/pmc/articles/PMC8584206/ | discovery | ad | appxhqc-mice mice | ||||
Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation | 2021 | Discovery | Niemann-Pick disease | Mice, NPC1 mice | Kristina Dominko 1, Ana Rastija 1, Sandra Sobocanec 2, Lea Vidatic 1, Sarah Meglaj 3, Andrea Lovincic Babic 3, Birgit Hutter-Paier 4, Alessio-Vittorio Colombo 5, Stefan F Lichtenthaler 5 6 7, Sabina Tahirovic 5, Silva Hecimovic 1 | 1 – Laboratory for Neurodegenerative Disease Research, Division of Molecular Medicine, Ruder Boskovic Institute, 10000 Zagreb, Croatia. | 10.3390/ijms222413256 | www.ncbi.nlm.nih.gov/pmc/articles/PMC8705785/ | discovery | niemann-pick-disease | mice npc1-mice | |||||
Leukotriene Signaling as a Target in α-Synucleinopathies | 2022 | Discovery | PD | Alpha-synuclein mouse models, Mice | Montelukast; Parkinson’s disease; dementia with Lewy bodies; leukotriene signaling pathway; α-synucleinopathy | Katharina Strempfl 1 2 3, Michael S Unger 1 2, Stefanie Flunkert 3, Andrea Trost 4, Herbert A Reitsamer 4, Birgit Hutter-Paier 3, Ludwig Aigner 1 2 | 1 – Institute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria. | 10.3390/biom12030346 | www.ncbi.nlm.nih.gov/pmc/articles/PMC8944962/ | discovery | pd | alpha-synuclein-mouse-models mice | ||||
No association between initiation of phosphodiesterase-5 inhibitors and risk of incident Alzheimer's disease and related dementia: results from the Drug Repurposing for Effective Alzheimer's Medicines study | 2020 | Discovery | AD | Human | Alzheimer’s disease; PDE5 inhibitors; cohort study; dementia; repurposing | Rishi J Desai 1, Mufaddal Mahesri 1, Su Been Lee 1, Vijay R Varma 2, Tina Loeffler 3, Irene Schilcher 3, Tobias Gerhard 4 5, Jodi B Segal 6, Mary E Ritchey 4, Daniel B Horton 4 7, Seoyoung C Kim 1 8, Sebastian Schneeweiss 1, Madhav Thambisetty 2 | 1 – Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital & Harvard Medical School, Boston, MA 02115, USA. | 10.1093/braincomms/fcac247 | www.ncbi.nlm.nih.gov/pmc/articles/PMC9598543/ | discovery | ad | human | ||||
Hydroxychloroquine lowers Alzheimer's disease and related dementias risk and rescues molecular phenotypes related to Alzheimer's disease | 2022 | Discovery | AD | APP/PS2 mice, Mice | Psychiatric disorders, Drug discovery | Vijay R Varma 1, Rishi J Desai 2, Sheeja Navakkode 3 4, Lik-Wei Wong 4 5, Carlos Anerillas 6, Tina Loeffler 7, Irene Schilcher 7, Mufaddal Mahesri 2, Kristyn Chin 2, Daniel B Horton 8, Seoyoung C Kim 2, Tobias Gerhard 8, Jodi B Segal 9, Sebastian Schneeweiss 2, Myriam Gorospe 6, Sreedharan Sajikumar 4 5 10, Madhav Thambisetty 11 | 1 – Clinical and Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA. | 10.1038/s41380-022-01912-0 | www.ncbi.nlm.nih.gov/pmc/articles/PMC10005941/ | discovery | ad | app-ps2-mice mice | ||||
Evaluating the effect of R-Baclofen and LP-211 on autistic behavior of the BTBR and Fmr1-KO mouse models | 2023 | Discovery | Autism spectrum disorder | BTBR mice, Fmr1-KO mice, Mice | autism spectrum disorders, locomotor behavior, anxiety, repetitive behavior, ultrasonic vocalization, GABAB receptor agonist, 5-HT7 receptor agonist | Shirin Sharghi 1 2, Stefanie Flunkert 1, Magdalena Daurer 1, Roland Rabl 1, Boris Philippe Chagnaud 2, Marcello Leopoldo 3, Enza Lacivita 3, Birgit Hutter-Paier 1, Manuela Prokesch 1 | 1 – Department of Neuropharmacology, QPS Austria GmbH, Grambach, Austria. | doi.org/10.3389/fnins.2023.1087788 | pubmed.ncbi.nlm.nih.gov/37065917/ | discovery | autism-spectrum-disorder | btbr-mice fmr1-ko-mice mice | ||||
Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer's disease-related blood brain barrier dysfunction and inflammation | 2023 | Discovery | AD | Murine organotypic hippocampal slice cultures, Primary porcine brain capillary endothelial cells | Amyloid beta; Astaxanthin; Autophagy; Blood-brain barrier; Inflammation. | Joshua Adekunle Babalola 1, Magdalena Lang 2, Meekha George 3, Anika Stracke 2, Carmen Tam-Amersdorfer 2, Izaskun Itxaso 4, Domjan Lucija 4, Jelena Tadic 5, Irene Schilcher 4, Tina Loeffler 4, Stefanie Flunkert 4, Manuela Prokesch 4, Gerd Leitinger 6, Achim Lass 5, Birgit Hutter-Paier 4, Ute Panzenboeck 2, Gerald Hoefler 7 | 1 – Diagnostic and Research Institute of Pathology, Medical University of Graz, Austria. | 10.1016/j.brainres.2023.148518 | pubmed.ncbi.nlm.nih.gov/37579986/ | discovery | ad | murine-organotypic-hippocampal-slice-cultures primary-porcine-brain-capillary-endothelial-cells | ||||
Effect of astaxanthin in type-2 diabetes -induced APPxhQC transgenic and NTG mice | 2024 | Discovery | AD, Type-2 diabetes | APPxhQC mice, Mice | Alzheimer's disease; Astaxanthin; Metabolic perturbation; Pyroglutamylation; Type 2 diabetes. | Joshua Adekunle Babalola 1, Anika Stracke 2, Tina Loeffler 3, Irene Schilcher 3, Sideromenos Spyridon 4, Stefanie Flunkert 3, Joerg Neddens 3, Ake Lignell 5, Manuela Prokesch 3, Ute Pazenboeck 2, Herbert Strobl 2, Jelena Tadic 6, Gerd Leitinger 7, Achim Lass 6, Birgit Hutter-Paier 3, Gerald Hoefler 8 | 1 – Diagnostic and Research Institute of Pathology Medical University of Graz, Graz, Austria. | 10.1016/j.molmet.2024.101959 | pubmed.ncbi.nlm.nih.gov/38763496/ | discovery | ad type-2-diabetes | appxhqc-mice mice | ||||
Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms | 2024 | Discovery, Regulatory Toxicology | Göttingen Minipig | Bloodsampling; Cortisol; HPA-axis; MiniPigs; PKPD; PRACMA; Pharmacokinetics; Pharmacology; Stress | Frederik Rode 1 ,Christoffer Bundgaard 2 , Johan Areberg 2 , Lone Bruhn Madsen 3 , Ida Taavoniku 3 , Lene Hansen 2 , Johan Weisser 2 , Line Rørbæk Olsen 2 , Heidi Toft Elgaard 2 , Elin Eneberg 2 , Michael Didriksen 2 |
| 10.1016/j.vascn.2024.107504 | pubmed.ncbi.nlm.nih.gov/38678804/ | discovery regulatory-toxicology | gottingen-minipig | ||||||
Biodistribution, persistence and lack of integration of a multigene HIV vaccine delivered by needle-free intradermal injection and electroporation | 2010 | Discovery | HIV | Mice | Electroporation; Skin; Dermal; HIV; Plasmid; DNA; Bioject | Andreas Bråve a b, Lindvi Gudmundsdotter a b, Eric Sandström c, B. Kristian Haller d, David Hallengärd a b, Anna-Karin Maltais e, Alan D. King f, Richard R. Stout g, Pontus Blomberg h, Urban Höglund i, Bo Hejdeman c, Gunnel Biberfeld a, Britta Wahren a b | a – Swedish Institute for Infectious Disease Control, Solna, Sweden | 10.1016/j.vaccine.2010.08.108 | www.sciencedirect.com/science/article/pii/S0264410X10014489?via%3Dihub | discovery | hiv | mice | ||||
The Use of Minipigs in Non-Clinical Research | 2013 | Regulatory Toxicology | Other | Göttingen Minipig | Peter Glerup, Nanna Grand, Mikala Skydsgaard | Scantox A/S, Lille Skensved, Denmark | 10.1016/B978-0-12-415759-0.00013-3 | www.researchgate.net/publication/285181945_The_Use_of_Minipigs_in_Non-Clinical_Research | regulatory-toxicology | other | gottingen-minipig | |||||
Repeated measurements of motor activity in rats in long-term toxicity studies | 2014 | Regulatory Toxicology | Other | Rats | V. Golozoubova, T.K. Brodersen, S. Klastrup, M. Oksama, J. Løgsted, A. Makin | Scantox A/S, Lille Skensved, Denmark | 10.1016/j.vascn.2014.06.007 | www.sciencedirect.com/science/article/abs/pii/S105687191400224X?via%3Dihub | regulatory-toxicology | other | rats | |||||
Transepidermal water loss and tape stripping in minipig skin | 2015 | Regulatory Toxicology | Other | Göttingen Minipig | A. Makin, Sisse Ellemann-Laursen, Nanna Grand, Gitte Jeppesen, T. Starostka, J. Løgsted, K. Kaaber | 10.1016/j.toxlet.2015.08.781 | www.researchgate.net/publication/282527493_Transepidermal_water_loss_and_tape_stripping_in_minipig_skin | regulatory-toxicology | other | gottingen-minipig | ||||||
Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer | 2015 | Discovery | Cancer | Mice | Wojciech Senkowski; Xiaonan Zhang; Maria Hägg Olofsson; Ruben Isacson; Urban Höglund; Mats Gustafsson; Peter Nygren; Stig Linder; Rolf Larsson; Mårten Fryknäs | Uppsala University, Klinisk Farmakologi, ing 61 4tr, Dag Hammarskjölds Väg 18, 751 85 Uppsala, Sweden | 10.1158/1535-7163.MCT-14-0792 | aacrjournals.org/mct/article/14/6/1504/92034/Three-Dimensional-Cell-Culture-Based-Screening | discovery | cancer | mice | |||||
Changes in energy metabolism due to acute rotenone-induced mitochondrial complex I dysfunction – An in vivo large animal model | 2016 | Discovery | Other | Göttingen Minipig | Michael Karlsson a b 1, Johannes K. Ehinger a b 1, Sarah Piel a b, Fredrik Sjövall a, Johanna Henriksnäs c, Urban Höglund c, Magnus J. Hansson a b, Eskil Elmér a b | a – Mitochondrial Medicine, Department of Clinical Sciences, Lund University, BMC A13, SE-221 84 Lund, Sweden | 10.1016/j.mito.2016.10.003 | www.sciencedirect.com/science/article/abs/pii/S1567724916302082?via%3Dihub | discovery | other | gottingen-minipig | |||||
In Vivo Electroporation Enhances the Immunogenicity of Hepatitis C Virus Nonstructural 3/4A DNA by Increased Local DNA Uptake, Protein Expression, Inflammation, and Infiltration of CD3+ T Cells | Discovery | Hepatitis C | Mice | Gustaf Ahlén; Jonas Söderholm; Torunn Tjelle; Rune Kjeken; Lars Frelin; Urban Höglund; Pontus Blomberg; Michael Fons; Iacob Mathiesen; Matti Sällberg | Division of Clinical Microbiology, F68, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden | Online ISSN: 1550-6606 | journals.aai.org/jimmunol/article/179/7/4741/37980/In-Vivo-Electroporation-Enhances-the | discovery | hepatitis-c | mice | ||||||
Bladder cancer therapy without toxicity—A dose-escalation study of alpha1-oleate | 2020 | Discovery | Cancer | Mice | Pham-Tue-Hung Tran1, Naveed Asghar1, Urban Höglund2, Olivia Larsson2, Lars Haag3, Ali Mirazimi4,5, Magnus Johansson1, Wessam Melik1 | 1 – School of Medical Science, Inflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, 703 62 Örebro, Sweden | 10.3390/microorganisms8121890 | www.mdpi.com/2076-2607/8/12/1890 | discovery | cancer | mice | |||||
Development of an Experimental Ex Vivo Wound Model to Evaluate Antimicrobial Efficacy of Topical Formulations | 2021 | Discovery | Wound Healing | Göttingen Minipig | antibiotics; antimicrobial; biofilm; burn; ex vivo; wound healing; wound model. | Madalene Å Andersson1, Lone Bruhn Madsen2, Artur Schmidtchen 3,4,5, Manoj Puthia5 | 1 – In2Cure AB, Medicon Village, SE-22381 Lund, Sweden. | 10.3390/ijms22095045 | pubmed.ncbi.nlm.nih.gov/34068733/ | discovery | wound-healing | gottingen-minipig | ||||
Probing Skin Barrier Recovery on Molecular Level Following Acute Wounds: An In Vivo/Ex Vivo Study on Pigs | 2021 | Wound Healing | Göttingen Minipig | acute wound; histology; in vivo/ex vivo; lipid; pH; polarization transfer solid state NMR (PTssNMR); skin barrier; small and wide-angle X-ray diffraction (SWAXD); stratum corneum; trans-epidermal water loss (TEWL). | Enamul Haque Mojumdar 1, 2, Lone Bruhn Madsen3, Henri Hansson4, Ida Taavoniku3, Klaus Kristensen3, Christina Persson5, Anna Karin Morén4, Rajmund Mokso6, Artur Schmidtchen7, Tautgirdas Ruzgas1, 2, Johan Engblom1, 2 | 1 – Department of Biomedical Science, Faculty of Health and Society, Malmö University, SE-205 06 Malmö, Sweden. | 10.3390/biomedicines9040360 | pubmed.ncbi.nlm.nih.gov/33807251/ | wound-healing | gottingen-minipig | ||||||
Behavioral Biology of Pigs and Minipigs | 2021 | Regulatory Toxicology | Other | Göttingen Minipig | Sandra Edwards, Nanna Grand | Book: Behavioral Biology of Laboratory Animals, ISBN: 9780429019517 | www.taylorfrancis.com/chapters/edit/10.1201/9780429019517-17/behavioral-biology-pigs-minipigs-sandra-edwards-nanna-grand?context=ubx&refId=473a7a55-7628-4173-904a-641631685bdb | regulatory-toxicology | other | gottingen-minipig | ||||||
Enhanced Seroconversion to West Nile Virus Proteins in Miceby West Nile Kunjin Replicon Virus-like Particles Expressing Glycoproteins from Crimean–Congo Hemorrhagic Fever Virus | 2022 | Discovery | Other | Mice | Pham-Tue-Hung Tran1, Urban Höglund2, Olivia Larsson2, Sofia Appelberg3, Ali Murazimi4,5, Magnus Johansson1, Wessam Melin1 | 1 – School of Medical Science, Inflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, 703 62 Örebro, Sweden | 10.3390/pathogens11020233 | www.mdpi.com/2076-0817/11/2/233 | discovery | other | mice | |||||
Macromolecular Viral Entry Inhibitors as Broad‐SpectrumFirst‐Line Antivirals with Activity against SARS‐CoV‐2 | 2022 | Discovery | SARS-CoV | Mice | broad‐spectrum antivirals, entry inhibitors, in vivo, macromolecules, polyanions, respiratory syncytial virus (RSV), SARS‐CoV‐2 | Rüdiger Groß1, Lívia Mesquita Dias Loiola2,3, Leila Issmail4, Nadja Uhlig4, Valentina Eberlein4, Carina Conzelmann1, Lia‐Raluca Olari1, Lena Rauch1, Jan Lawrenz1, Tatjana Weil1, Janis A. Müller1, Mateus Borba Cardoso3, Andrea Gilg1, Olivia Larsson5, Urban Höglund5, Sandra Axberg Pålsson6, Anna Selch Tvilum2, Kaja Borup Løvschall2, Maria M. Kristensen2, Anna‐Lena Spetz6, Fortune Hontonnou7, Marie Galloux7, Thomas Grunwald4, Alexander N. Zelikin2, Jan Münch1 | 1 – Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081 Germany | 10.1002/advs.202201378 | www.ncbi.nlm.nih.gov/pmc/articles/PMC9284172/ | discovery | sars-cov | mice | ||||
A universal SARS-CoV DNA vaccine inducing highlycross-reactive neutralizing antibodies and T cells | 2022 | Discovery | SARS-CoV | Mice | Sofia Appelberg 1, Gustaf Ahlén2, Jingyi Yan2, Negin Nikouyan2, Sofie Weber3, Olivia Larsson3, Urban Höglund3, Soo Aleman4, Friedemann Weber5, Emma Perlhamre6, Johanna Apro6, Eva‐Karin Gidlund7, Ola Tuvesson7, Simona Salati8, Matteo Cadossi8, Hanna Tegel9, Sophia Hober9, Lars Frelin2, Ali Mirazimi1, and Matti Sällberg2 | 1 – Public Health Agency of Sweden Solna Sweden | 10.15252/emmm.202215821 | www.embopress.org/doi/full/10.15252/emmm.202215821 | discovery | sars-cov | mice | |||||
Development of a Multivalent Kunjin Virus Reporter Virus-LikeParticle System Inducing Seroconversion for Ebola and West Nile Virus Proteins in Mice | 2022 | Discovery | Ebola | Mice | Pham-Tue-Hung Tran1, Naveed Asghar1, Urban Höglund2, Olivia Larsson2, Lars Haag3, Ali Mirazimim4,5, Magnus Johansson1, Wessam Melik1 | 1 – School of Medical Science, Inflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, 703 62 Örebro, Sweden | 10.3390/microorganisms8121890 | www.mdpi.com/2076-2607/8/12/1890 | discovery | ebola | mice | |||||
Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2 | 2021 | SARS-CoV | Mice | antibodies, SARS – CoV – 2, antibody function, antibody binding, spike (S) protein, phagocytosis, in vivo model | Wael Bahnan1, Sebastian Wrighton1, Martin Sundwall1, Anna Läckberg1,2, Olivia Larsson3, Urban Höglund3, Hamed Khakzad4,5, Magdalena Godzwon6, Maria Walle6, Elisabeth Elder7, Anna Söderlund Strand8, Lotta Happonen1, Oscar André1, Johannes Kumra Ahnlide1, Thoms Hellmark9, Vidar Wendel-Hansen10, Robert P.A. Wallin11, Johan Malmström1, Lars Malmström1,12, Mats Ohlin6,13, Magnus Rasmussen1,2, Pontus Nordenfelt1 | 1 – Department of Clinical Sciences Lund, Infection Medicine, Faculty of Medicine, Lund University, Lund, Sweden | 10.3389/fimmu.2021.808932 | www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.808932/full | sars-cov | mice | ||||||
The Non-Human Primate in Safety Assessment of aBifunctional Long-Acting Insulin Analogue | 2023 | Regulatory Toxicology | Other | Other | non-clinical development, non-human primates, minipigs, cynomolgus monkey, safety assessment, long-acting insulin, PCSK9i | Vivi FH Jensen DVM PhD1, Nikolai K Jensen DVM1, Line H Schefe PhD1, Jens Sigh PhD1, Akiyemi Akintomide MSc2, Kari Kaaber DVM3, Sophia G Moesgaard DVM PhD4, Mona H Pedersen PhD1 | 1 – Global Drug Discovery and Development Sciences, Novo Nordisk A/S, Maaloev, Denmark | 10.1177/10915818231156898 | journals.sagepub.com/doi/10.1177/10915818231156898 | regulatory-toxicology | other | other | ||||
Alginate and Nanocellulose Dressings With Extract FromSalmon Roe Reduce Inflammation and Accelerate Healing of Porcine Burn Wounds | 2023 | Discovery | Wound Healing | Göttingen Minipig | Anti-inflammatory agents, oxidative stress, inflammation, alginates, bandages, burns, interleukins, macrophages, salmon, suidae, swine, miniature, wound healing, dressing of skin or wounds, inflammatory response, partial thickness burns | Karin M Gilljam PhD, Patrik Stenlund PhD, Simon Standort MSc, Sisse Bindslev Andersen DVM, | 10.1093/jbcr/irad006 | academic.oup.com/jbcr/article/44/5/1140/6987519?login=false | discovery | wound-healing | gottingen-minipig | |||||
Subclass-switched anti-spike IgG3 oligoclonal cocktailsstrongly enhance Fc-mediated opsonization | 2023 | Discovery | Fc-mediated function; affinity; oligoclonal; phagocytosis; subclass | Arman Izadi1, Arsema Hailu1, Magdalena Godwon2, Sebastian Wrighton1, Berit Olofsson1, Tobias Schmidt3,4, Anna Söderlund-Strand5, Elizabeth Elder6, Sofia Appelberg7, Maria Valsjö8, Olivia Larsson8, Vidar Wendel-Hansen9, Mats Ohlin2,10, Wael Bahnan1, Pontus Nordenfelt1,5. | 1 – Department of Clinical Sciences Lund, Division of Infection Medicine, Faculty of Medicine, Lund University, 221 84 Lund, Sweden. | pubmed.ncbi.nlm.nih.gov/37011197/ | discovery | |||||||||
Iodine loaded nanoparticles with commercial applicabilityincrease survival in mice cancer models with low degree of side effects | 2023 | Discovery | Cancer | Mice | cytotoxic; drug delivery; molecular iodine; nanoparticles; side effects. | Torkel Falkenberg, Olivia Larsson, Bengt Hedin, Shigeru Shiraki, Takahisa Karita | 10.1002/cnr2.1843 | pubmed.ncbi.nlm.nih.gov/37269144/ | discovery | cancer | mice | |||||
First virological and pathological study of Göttingen Minipigswith Dippity Pig Syndrome (DPS) | 2023 | Regulatory Toxicology | Other | Göttingen Minipig | Hina Jhelum, Nanna Grand, Kirsten Rosenmay Jacobsen, Sabrina Halecker, Michelle Salerno, Robert Prate, Luise Krüger, Yannick Kristiansen, Ludwig Krabben, Lars Möller, Michael Laue, Benedikt Kaufer, Kari Kaaber, Joachim Denner | Laboratory of Joachim Denner at the Robert Koch Institute and the Institute of Virology was supported by the Deutsche Forschungsgemeinschaft, TRR127. | 10.1371/journal.pone.0281521 | journals.plos.org/plosone/article?id=10.1371/journal.pone.0281521 | regulatory-toxicology | other | gottingen-minipig | |||||
Comparison of efficacy between subcutaneous andintravenous application of moss-aGal in the mouse model of Fabry disease | 2023 | Discovery | Other | Mice | enzyme replacement therapy, Fabry disease, moss-aGal, subcutaneous application | Paulina Dabrowska-Schlepp1, Andreas Busch1, Jin-Song Shen2, Rachel Y. Cheong3, Lone Bruhn Madsen3, | 1 – Eleva GmbH, Freiburg, Germany | 10.1002/jmd2.12393 | scantox.com/wp-content/uploads/2023/09/JIMD-Reports-2023-DabrowskaSchlepp.pdf | discovery | other | mice |