Efficacy - Scantox


Preclinical efficacy studies form the fundamental basis of research pharmacology and drug development.

In efficacy studies the pharmacological effects of test compounds are investigated in laboratory animal models that have been developed to mimic the human disease. Such studies are of key importance to predict the success of treatment in humans with the disease.

Because preclinical efficacy studies are so critical to the decisions made about a possible future therapy, it is very important that studies done at this stage are based on best practice. This minimizes the risk of discarding a useful therapy, or conversely, taking an unsuccessful compound into further development.

Scantox is a dedicated and highly qualified partner for preclinical efficacy studies.

Our competent and experienced team is known for responsiveness and scientific sound study designs. In rodent models we are mostly working within the areas of oncology, infection (BSL2 and BSL3), inflammation and diabetology and have also experience with several rare diseases within the orphan drug indications. In porcine models we have established models of dermatology and wound healing and operation facilities for proof of concept studies that involves implants and surgical intervention.

Experimental set up and establishment of disease models

Innovative new therapies often require flexible and client tailored efficacy studies in order to demonstrate early proof of concept. Therefore, as a natural part of our services, we also offer experimental set up and establishment of disease models according to client requirements.

When tailoring efficacy studies to the specific requirements of the sponsor, we do our very best to unify the need for pharmacological data collectipon and optimized animal welfare.


Efficacy Models and Study types

Scantox is working with a variety of different disease models in rodents as well as non-rodents. Some of these are well-known as they are frequently used for research procedures of more general nature. Others on the other hand, are specifically designed and customized for special projects. We have substantial experience in establishing and validating customized models, or even developing new models to meet specific requirements in close collaboration with the client.

Examples of our current in-house models

· Oncology models: syngeneic and xenografts
· Vaccine studies – infectious agents and cancer
· Infection studies, at BSL2 and BSL3
· Kidney damage/kidney transplant
· Blood coagulation disorders
· Inflammatory bowel disease
· Peritonitis
· Diabetes
· Wound Healing

· Behavioral studies
· Rare diseases including
· blood diseases
· liposomal storage disease,
· neurodegenerative diseases, and
· mitochondrial disorders
· Experimental surgery
· Veterinary vaccine development

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For more information

…or discussions on other models, do not hesitate to contact us.