MJFF 마우스 모델

연구자들의 시간과 자원을 절약하기 위해 마이클 J. 폭스 재단에서는 과학 커뮤니티에 다양한 도구를 저렴한 비용으로 신속하게 제공하고 있습니다. Scantox는 고객에게 다음과 같은 MJFF 마우스 모델을 제공할 수 있는 권리를 획득했으며, 이 모델에서 연구를 수행할 수 있도록 기꺼이 도와드리겠습니다.

Ninja Column 1Ninja Column 2Ninja Column 3Ninja Column 4Ninja Column 5Ninja Column 6
Target
Common Name
Allele Type
JAX strain
Description
Active link
LRRK1LRRK1 KOKnockout16120knockout exons 24 throught 29 of Lrrk1https://www.jax.org/strain/016120
LRRK1LRRK1 KOKnockout22880knockout exons 24 throught 29 of Lrrk1, no Pde6bhttps://www.jax.org/strain/022880
LRRK1 and LRRK2LRRK1/2 double KO16122knockout exons 24 throught 29 of Lrrk1 and knockout exons 39 throught 40 of Lrrk2https://www.jax.org/strain/016122
LRRK2BAC Human LRRK2 wildtypeKnockout13725BAC transgene expresisng WT LRRK2 enodgenouse promotorhttps://www.jax.org/strain/013725
LRRK2BAC Human LRRK2 R1441GTransgenic18786BAC LRRK2(R1441G) enodenous promotorhttps://www.jax.org/strain/018786
LRRK2BAC Human LRRK2 G2019STransgenic18785BAC LRRK2 (G2019S) transgenehttps://www.jax.org/strain/018785
LRRK2LRRK2 KOTransgenic16121knockout exons 39 throught 40 of Lrrk2https://www.jax.org/strain/016121
LRRK2LRRK2 D1994A KIKnockout21830D1994A point mutation in Lrrk2https://www.jax.org/strain/021830
LRRK2LRRK2 T1348N KIKnockin21829T1348N point mutation in Lrrk2https://www.jax.org/strain/021829
LRRK2LRRK2 A2016T KIKnockin21828A2016T point mutation in Lrrk2https://www.jax.org/strain/021828
SNCABAC Human alphasynuclein wildtypeKnockin18442BAC murine promotor Human WT SNCAhttps://www.jax.org/strain/018442
SNCAmThy-1 Human alpha-synucleinTransgenic16936Murine Thy1 promotor, human WT SNCAhttps://www.jax.org/strain/016936
SNCAmThy-1 Human alpha-synucleinTransgenic17682Murine Thy1 promotor, human WT SNCAhttps://www.jax.org/strain/017682
SNCAAlpha-synuclein KOKnockout16123knockout exons 1 through 4 of murine SNCAhttps://www.jax.org/strain/016123
Eif4g1Eif4g1 R1207HKnockin24521R1207H in exon 24, as well as loxP sites flanking exons 24 to 28. Crebmediated recombination removes exon 24 to 28 resulting in null allele.https://www.jax.org/strain/024521
Eif4g1Eif4g1 KOConditional Knockout21827LoxP sites flanking exons 24 to 28. Creb-mediated recombination removed exon 24 to 28 resulting in null allele.https://www.jax.org/strain/021827
VPS35VPS35 D620N KIKnockin23409D620N mutation in exon 15https://www.jax.org/strain/023409
VPS35VPS35 D620N KIfloxΔneo Vps35Conditional Knockout21807Cre recombinase inducible D620N mutation in exon 15https://www.jax.org/strain/021807
GBAGBA D409V KIKnockin19106Gba D427V mutant protein corresponse to D409Vhttps://www.jax.org/strain/019106

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