Since 2004 we have performed numerous wound healing studies in rats and minipigs. The wound healing studies have been conducted to investigate e.g. safety, toxicity and bioavailability of wound dressings, formulations, dermal patches etc. Other wound healing studies have been conducted to assist during the early development of formulations and medical devices. We offer both full thickness and split thickness (partial thickness) wound healing studies.
Wounding of split thickness wounds are performed using an electrodermatome which removes the epidermis and the upper part of dermis. The wounds are superficial and will heal quickly (typically within 7 days) by re-epithelialization.
In full thickness wound healing studies, the epidermis, dermis and subcutis are removed. The wounds heal by granulation followed by re-epithelization, the healing process will be complete within approximately 3 weeks. During the healing period the wounds will be evaluated at suitable timepoints.
Typically, the wound evaluation will be supported by other parameters e.g. clinical observations, blood sampling for toxicokinetic and clinical pathology.
Occasionally, wound healing studies on abraded skin are requested by the authorities and we have experience in performing combined wound healing evaluation in repeat toxicology studies in minipigs. Please request for further information, should this be of interest.