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Alzheimer’s Disease In Vitro Models
Aβ Induced Toxicity
Aβ Peptide Formation or Screening for Secretase Inhibitors
Determination of Aβ Aggregates
Tau Hyperphosporylation
Tau Uptake and Seeding
Tau Aggregation In Vitro
Parkinson’s Disease In Vitro Models
PD-Specific Lesion-Induced Neurotoxicity
Mitochondrial Impairment
α-synuclein Aggregation, Seeding and Autophagy
Neuronal Plasticity
Neurogenesis
Neurite Outgrowth
Synaptogenesis
Neuronal Activity
Neuroinflammation
BV-2 cells
Primary Mouse Microglia
Organotypic Hippocampal Brain Slices
Human iPSC-Derived Microglia
Phagocytosis
Lesion Induced In Vitro Models
Sodium Arsenite-Induced Stress Granule Formation
Excitotoxicity: L-Glutamate-Induced Lesion of Neuronal Cells
Neuronal Survival: Growth Factor Withdrawal
In Vivo Services
In Vivo Animal Models
Alzheimers Disease Transgenic Mouse Models
APP
SL
Transgenic Mouse Model
APP
SL
x hQC Transgenic Mouse Model
5xFAD Transgenic Mouse Model
APP-SAA Knock-in Mouse Model
Tg2576 Transgenic Mouse Model
TMHT Transgenic Mouse Model
hTau Transgenic Mouse Model
PS19 Transgenic Mouse Model
Parkinsons Disease Transgenic Mouse Models
D-Line Transgenic Mouse Model
Line 61 Transgenic Mouse Model
hA53Ttg Transgenic Mouse Model
LRRK2 G2019S Rat Model
GBA D409V KI Mouse Model
Additional Parkinson’s Disease Models
Amyotrophic Lateral Sclerosis Transgenic Mouse Models
SOD1-G93A Transgenic Mouse Model
SOD1-G93A/low Transgenic Mouse Model
TDP-43 Transgenic Mouse Models
B6.SOD1-G93A Transgenic Mouse Model
Huntington’s Disease Models
R6/2 Transgenic Mouse Model
zQ175 Transgenic Mouse Model
BACHD Transgenic Rat Model
Lysosomal Storage Disease Models
NPC1
-/-
Mouse Model
4L/PS-NA Transgenic Mouse Model
GBA D409V KI Mouse Model
Pompe 6
neo
Mouse Model
Mucopolysaccharidosis IIIA Mouse Model
Induced Disease Models
Alzheimer’s Disease
Amyotrophic Lateral Sclerosis
Gaucher Disease
Neuroinflammation
Migraine
Multiple Sclerosis
Parkinson’s Disease
Schizophrenia
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BTBR T+ tf/J Mouse Model
Fmr1
-KO Mouse Model
Nlrp3
A350VneoR
Mouse Model
In Vivo Behavioral Tests
General Health & Activity Levels
Glucose Tolerance Test
Irwin Test
Nest Building Test
Open Field Test
Cognitive Tests
Barnes Maze Test
Contextual Fear Conditioning Test
Morris Water Maze Test
Novel Object Recognition Test
Passive Avoidance Test
Two Choice Swim Test
Y-Maze Test
Motor Ability Tests
Beam Walk Test
Grip Strength
Pasta Gnawing Test
Pole Test
RotaRod Test
Wire Hanging Test
Electrophysiology (CMAP, MUNE)
Anxiety & Depression Tests
Elevated Plus Maze
Forced Swim Test
Marble Burying Test
Social Behavior Tests
Autogrooming Test
Three Chamber Social Test
Lateral Lesion Tests
Corner Turn Test
Corridor Test
Cylinder Test
Rotation Test
Ex Vivo Services
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Molecular Biology – Biomarker
Rodent Biobank
Wound Healing
Rare Diseases
Kidney Diseases
Col4A3 Knockout Mouse Model
Obesity
Obesity Model / Metabolic Syndrome
Liver Diseases
Liver Fibrosis
Other efficacy models
Colitis Animal Models
PK/PD
Exploratory Toxicology
Local Tolerance Studies
Infectious Diseases and Vaccines
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Mutagen Testing
Ames II and Ames MPF Test
Ames 24-well Agar Test
Full Plate Ames Test
Clastogens and Aneugens
MicroFlow Flow MNT Test
Multiflow® Test
96-Well MNT and FISH Test
OECD 487 In Vitro Micronucleus Test
All Mechanisms
BlueScreen HC
Multiflow® Test
GLP Genotoxicity Services
GLP OECD 471 Ames Test
OECD 487 In Vitro Micronucleus Test
OECD 490 GLP Mouse Lymphoma Assay (MLA)
OECD 476: HPRT Assay
OECD 474: In Vivo Micronucleus Test
OECD 488: Big Blue® Transgenic Rodent Somatic and Germ Cell Gene Mutation Assay Test
GLP Skin and Ocular Toxicology
GLP Skin Toxicology
OECD 431: In Vitro Skin Corrosion Test using Reconstructed Human Epidermis (RhE)
OECD 439: In Vitro Skin Irritation Test using Reconstructed Human Epidermis (RhE)
OECD 432: Phototoxicity Test
GLP Ocular Toxicology Studies
OECD 437: Bovine Corneal Opacity and Permeability Test (BCOP)
OECD 492: EpiOcular™ Eye Irritation Test
Skin Sensitisation Tests
OECD 442C: Direct Peptide Reactivity Assay Test
OECD 442D KeratinoSens™ Test
OECD 442E: h-CLAT Test
Regulatory Toxicology
Toxicology
General Toxicology
Investigational New Drug (IND)-Enabling Capabilities
Juvenile Toxicology Studies in Minipigs
Embryofetal Toxicology
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Humanized lgG Göttingen Minipigs
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Establishment of AD-relevant organoid models
Establishment of AD-relevant organoid models
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