Longitudinal progression of blood biomarkers reveals a key role of reactive astrocytosis in preclinical Alzheimer’s disease

Vijay R. Varma,¹ Yang An,² Przemek R. Kac,³ Murat Bilgel,² Abhay Moghekar,⁴ Tina Loeffler,⁵ David Amschl,⁵ Magdalena Daurer,⁵ Manuela Prokesch,⁵ Juan Troncoso,⁶ Kaj Blennow,^3,7 Henrik Zetterberg,^{3,7,8,9,10,11} Nicholas J. Ashton,^3,12,13 Luigi Ferrucci,¹⁴ Susan M. Resnick,² and Madhav Thambisetty¹