科学ポスター
Scantoxは、科学者たちが質の高い研究結果を発表し、広めることを奨励しており、そのほとんどは顧客との緊密な協力の下で行われています。
| Title | Year | Scantox Business Unit | Disease | Model | Keywords | Authors | Affiliations | More details | hf:tax:division | hf:tax:disease | hf:tax:model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| In Vitro Systems Targeting TDP-43 Translocation, Stress Granules, and Stathmin-2 Splicing | 2024 | Discovery | ALS | Cell line, iPSCs | mRNA, alternative splicing, translocation, stress granule formation, cytosolic, nuclear | Andy Brown1, Tina Loeffler2, Irene Schilcher2, Irantzu Perez Ruiz2, Igor Cancar2, Magdalena Daurer2, Stefanie Flunkert2, | 1 Scantox Denmark ApS, Hestehavevej 36, 4623 Lille Skensved, Denmark | scantox.com/wp-content/uploads/2024/11/SfN2024-TDP-in-vitro_poster.pdf | discovery | als | cell-line ipscs |
| Accelerated Aging and Senescence in Cerebral Organoids | 2024 | Discovery | n/a | Cerebral Organoids | D-Galactose induction, senescence | Tina Loeffler, Izaskun Itxaso, Irene Schilcher, Irantzu Perez Ruiz, Magdalena Daurer, Stefanie Flunkert, Manuela Prokesch | Scantox Neuro GmbH, Parkring 12, Grambach, Austria | scantox.com/wp-content/uploads/2024/11/SfN2024-Organoids_poster.pdf | discovery | n-a | cerebral-organoids |
| Modeling Depression in Rats: Chronic Corticosterone Administration as a Tool for Antidepressant Efficacy Assessment | 2024 | Discovery | Depression | Rats | Behavior, Sucrose preference, Open field, Forces Swim test, Grooming, Coat Score | Ewald Auer, Aaron Fantina-Woblistin, Livia Breznik, Magdalena Daurer, Stefanie Flunkert, Manuela Prokesch | Scantox Neuro GmbH, Parkring 12, 8074 Grambach, Austria | scantox.com/wp-content/uploads/2024/11/SfN2024-Depression_poster.pdf | discovery | depression | rats |
| AAV-Human A53T-Mutated Synuclein Disrupts Nigro-Striatal System in Mice | 2024 | Discovery | PD | C57BL6 mice | Parkinson's disease, pathology, histology, unilateral, substantia nigra, caudate putamen | Ewald Auer, Tina Loeffler, Magdalena Daurer, Livia Breznik, Joerg Neddens, Stefanie Flunkert, Manuela Prokesch | Scantox Neuro GmbH, Parkring 12, 8074 Grambach, Austria | scantox.com/wp-content/uploads/2024/11/SfN2024-AAV-A53T-poster.pdf | discovery | pd | c57bl6-mice |
| Advancements in Preclinical Gene Therapy | 2024 | Discovery | n/a | 4L/PS-NA mice, Cell line, Rats | Compound administration routes, surgery techniques, in vivo CSF sampling, cell viability, toxicology, MTT assay, antisense oligonucleotides (ASO), | S Sharghi1, M Daurer1, T Loeffler1, S Flunkert1, D Brunner1, L Bruhn Madsen2, | 1 Scantox Neuro GmbH, A-8074, Parkring 12, Grambach, Austria | scantox.com/wp-content/uploads/2024/11/ESGCT2024_Advancements-in-preclinical-gene-therapy-poster.pdf | discovery | n-a | 4l-ps-na-mice cell-line rats |
| Characterization of an Inducible AAV9-hTDP-43 Mouse Model for ALS | 2024 | Discovery | ALS | C57BL6 mice | Neurodegeneration, motor deficits, astrocytosis, atrophy, motor cortex | Benedikt Kien, Livia Breznik, Magdalena Daurer, Tina Loeffler, Laurenz Jauk, Stefanie Flunkert, Manuela Prokesch | Scantox Neuro GmbH, Neuropharmacology, Grambach, Austria | scantox.com/wp-content/uploads/2024/11/ESGCT2024_AAV-TDP43-poster.pdf | discovery | als | c57bl6-mice |
| Viral Gene Delivery Approach to Mimic α-Synuclein Pathology in a Preclinical Model for Parkinson`s Disease | 2024 | Discovery | PD | C57BL6 mice | Unilateral, substantia nigra, AAV-vector, caudate putamen | Stefanie Krassnig, Tina Loeffler, Magdalena Daurer, Livia Breznik, Joerg Neddens, | Scantox Neuro GmbH, Neuropharmacology, Grambach, Austria | scantox.com/wp-content/uploads/2024/11/ESGCT2024_AAV-A53T-poster.pdf | discovery | pd | c57bl6-mice |
| LPS and Pre-Aggregated Aβ1-42 Lead to an Increased Neuroinflammatory Response in Cerebral Organoids | 2024 | Discovery | AD, Neuroinflammation | Cerebral Organoids | Neuroinflammation, LPS, Aβ1-42, cerebral organoids | Izaskun Itxaso1,2, Tina Loeffler1, Irene Schilcher1, Magdalena Daurer1, Stefanie Flunkert1, Boris Chagnaud2, Manuela Prokesch1 | 1 Scantox Neuro GmbH, A-8074, Parkring 12, Grambach, Austria | scantox.com/wp-content/uploads/2024/11/FENS2024_Poster_Cerebral-organoids.pdf | discovery | ad neuroinflammation | cerebral-organoids |
| Behavioral and Histological Hallmarks of an Intrastriatal Rotenone Mouse Model for Parkinson's Disease | 2024 | Discovery | PD | C57BL6 mice | Rotenone, ER-stress, intrastriatal injection, motor deficits, neuroinflammation, neurodegeneratios | Paula Jauregi1,2, Roland Rabl1, Magdalena Daurer1, Livia Breznik1, Stefanie Flunkert1, Boris Chagnaud2, Manuela Prokesch1 | 1 Scantox Neuro GmbH, A-8074, Parkring 12, Grambach, Austria | scantox.com/wp-content/uploads/2024/11/FENS2024-poster-ER-stress-Rotenone.pdf | discovery | pd | c57bl6-mice |
| Mating of Göttingen Minipigs at Scantox for use in embryofoetal development studies | 2022 | Regulatory Toxicology | n/a | Göttingen Minipig | Estrous synchronization | Ellemann-Laursen, Sisse | Scantox A/S, Denmark | scantox.com/wp-content/uploads/2022/09/2022-09-SE-ETS-repro-Antwerp-1200x1400mm-v.3-final.pdf | regulatory-toxicology | n-a | gottingen-minipig |
| Comparative Analysis of In Vitro Systems for TDP-43 Pathology | 2024 | Discovery | AD, ALS, Frontotemporal lobar degeneration, PD | iPSCs, Neuroblastoma cells | TDP-43, Stress granules, Cryptic splicing, Sodium arsenite | Stefanie Krassnig, Tina Loeffler, Irene Schilcher, Irantzu Perez Ruiz, Magdalena Daurer, Stefanie Flunkert, Manuela Prokesch | Scantox Neuro GmbH, Neuropharmacology, Grambach, Austria | scantox.com/wp-content/uploads/2024/09/Scantox_Neuro4D_2024-In-vitro-TDP43-Models.pdf | discovery | ad als frontotemporal-lobar-degeneration pd | ipscs neuroblastoma-cells |
| Longitudinal Analysis of a Nitroglycerin-Induced Mouse Migraine Model | 2024 | Discovery | Migraine | Mice | Grimace scale, Grooming, Light/dark box, Sex differences | Aaron Fantina-Woblistin, Livia Breznik, Laurenz Jauk, Magdalena Daurer, Roland Rabl, Tina Löffler, Manuela Prokesch | Scantox Neuro GmbH, Neuropharmacology, Grambach, Austria | scantox.com/wp-content/uploads/2024/09/Scantox-Neuro-MTIS_2024-Migraine-animal-model.pdf | discovery | migraine | mice |