科学ポスター
Scantoxは、科学者たちが質の高い研究結果を発表し、広めることを奨励しており、そのほとんどは顧客との緊密な協力の下で行われています。
| Title | Year | Scantox Business Unit | Disease | Model | Keywords | Authors | Affiliations | More details | hf:tax:division | hf:tax:disease | hf:tax:model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Longitudinal NF-L Measurements in In Vivo CSF Samples for Tracking Pathology Progression in Mouse Models of Gaucher and Niemann-Pick Disease | 2025 | Discovery | Gaucher disease, Niemann-Pick disease | 4L/PS-NA mice, NPC1 mice | Lysosomal storage disease, Neurodegeneration, Biomarker, Longitudinal sampling, Neurofilament light chain, NPC1-/-, 4L/PS-NA | Loeffler T., Brunner D., MernikB., Plattner K., NeddensJ., Breznik L., Daurer M., Flunkert S., Prokesch M. | Scantox Neuro GmbH, Parkring12, 8074 Grambach, Austria | scantox.com/wp-content/uploads/2025/04/Scantox-Poster-Longitudinal-NF-L-Measurements-in-In-Vivo-CSF-Samples-for-Tracking-Pathology-.-Feb.2025.pdf | discovery | gaucher-disease niemann-pick-disease | 4l-ps-na-mice npc1-mice |
| Method for Evaluation of Placental Transfer in Embryofetal Developmental Studies in Göttingen Minipigs at Scantox | 2025 | Regulatory Toxicology | n/a | Göttingen Minipig | Embryofetal development study; Göttingen Minipig | Sisse Ellemann-Laursen, Nanna Grand | Scantox A/S, Hestehavevej 36A, 4623 Lille Skensved, Denmark | scantox.com/wp-content/uploads/2025/10/Scantox-Poster-Method-for-evaluation-of-placental-transfer-in-embryofetal-development.pdf | regulatory-toxicology | n-a | gottingen-minipig |
| Impact of SNCA A53T and GBA Gene Mutations on Neurite Outgrowth and Response to Parkinson's Disease Stressors in IPSC-Derived Neurons | 2025 | Discovery | Parkinson's disease | A53T-alpha-synuclein, iPSCs | Cell viability, MPP+, Rotenone, Mitochondrial activity, GCase activity | Perez-Ruiz I.1, Loeffler T.1, OosterveenT.2, Turner A.2, Daurer M.1, Breznik L.1, Flunkert S.1, Prokesch M.1 | 1Scantox Neuro GmbH, Grambach, Austria; | scantox.com/wp-content/uploads/2025/07/Scantox-Poster-Impact-of-SNCA-A53T-and-GBA-Gene-Mutations-on-Neurite-Outgrow-and-Response-Apr.2025.pdf | discovery | parkinsons-disease | a53t-alpha-synuclein ipscs |
| Compound Muscle Action Potential as a Translational Biomarker in Mouse Models of Parkinson's Disease | 2025 | Discovery | Parkinson's disease | A53T-alpha-synuclein | CMAP, Electromyography, hA53Ttg mice, | Breznik L., Daurer M., Fantina-Woblistin A., Rabl R., Flunkert S., Prokesch M. | Scantox Neuro GmbH, Grambach, Austria | scantox.com/wp-content/uploads/2025/07/Scantox-Poster-Compound-Muscle-Action-Potential-as-Translational-Biomarker-in-Mice-Apr.2025.pdf | discovery | parkinsons-disease | a53t-alpha-synuclein |
| Accelerating the Parkinson's Disease Phenotype in Line 61 Mice With D-Galactose | 2025 | Discovery | Parkinson's disease | Line 61 mice | Aging, Motor performance, Cognition, beta-galactosidase activity, MDA | Rabl R., Breznik L., Daurer M., Loeffler T., Fantina-Woblistin A., Flunkert S., Prokesch M. | Scantox Neuro GmbH, Grambach, Austria | scantox.com/wp-content/uploads/2025/07/Scantox-Poster-Accelerating-the-Parkinsons-Disease-Phenotype-in-Line-61-Mice-With-D-Galactose-Apr.2025.pdf | discovery | parkinsons-disease | line-61-mice |
| Accelerating Senescence in D-Galactose-Treated Mice | 2025 | Discovery | Aging | D-galactose induced mice | Aging, Motor performance, Cognition, beta-galactosidase activity, Wild type mice | Sharghi S., Breznik L., Daurer M., Loeffler T., Fantina-Woblistin A., Flunkert S., Prokesch M. | Scantox Neuro GmbH, Grambach, Austria | scantox.com/wp-content/uploads/2025/07/Scantox-Poster-Accelerating-Senescence-in-D-Galactose-Treated-Mice-Apr.2025.pdf | discovery | aging | d-galactose-induced-mice |
| Unraveling the Complexity of Rotenone-Induced Parkinson’s Disease in Mice: Longitudinal Evaluation of Disease Pathology | 2025 | Discovery | Parkinson's disease | Rotenone-induced mice | Motor deficits, Neuronal loss, Neuroinflammation, Astrocytosis, Activated microglia, Dopamine dysfunction, Caudate putamen, Substantia nigra | Jauregi P.1,2, Rabl R.1, Daurer M.1, Breznik L.1, Flunkert S.1, Chagnaud B.2, Prokesch M.1
| 1Scantox Neuro GmbH, Grambach, Austria; | scantox.com/wp-content/uploads/2025/07/Scantox-Poster-Unraveling-the-Complexity-of-Rotenone-Induced-PD-in-Mice-Apr.2025.pdf | discovery | parkinsons-disease | rotenone-induced-mice |
| Accelerated Aging in Cerebral Organoids | 2025 | Discovery | Alzheimer's disease | Cerebral Organoids | Human iPSCs, D-galactose, NFL, PAX6, GFAP, SNAP25, p53, p21, Senescence, NeuN, Astrocytosis, Synapses | Perez-Ruiz I., Loeffler T., Itxaso I., Daurer M., Breznik L., Flunkert S., Prokesch M. | Scantox Neuro GmbH, Grambach, Austria | scantox.com/wp-content/uploads/2025/07/Scantox-Poster-Accelerated-Aging-in-Cerebral-Organoids-Apr.2025-1.pdf | discovery | alzheimers-disease | cerebral-organoids |
| Human A53T-Mutated Synuclein Mouse Model with Disturbed Nigro-Striatal System to Study Parkinson’s Disease | 2025 | Discovery | Parkinson's disease | Alpha-synuclein mouse models | Dopamine transporter, Neuroinflammation, Activated microglia, T-cell infiltration, in situ hybridization, tyrosine hydroxylase | Breznik L., Daurer M., Loeffler T., Flunkert S., Prokesch M. | Scantox Neuro GmbH, Grambach, Austria | scantox.com/wp-content/uploads/2025/07/Scantox-Poster-Human-A53T-Mutated-Synuclein-Mouse-Model-with-Disturbed-Nigro-Striatal-System-Apr.2025.pdf | discovery | parkinsons-disease | alpha-synuclein-mouse-models |
| Evaluation of Cognitive Function in 4-and 6-months Old Line 61 Mice | 2025 | Discovery | Parkinson's disease | Line 61 mice | Cognition, Morris water maze, Wire hanging test, Y-maze test, Passive avoidance test, Search strategy, Irwin test | Rabl R., Fantina-Woblistin A., Daurer M., Breznik L., Loeffler T., Prokesch M. | Scantox Neuro GmbH, Grambach, Austria | scantox.com/wp-content/uploads/2025/07/Scantox-Poster-Evaluation-of-Cognitive-Function-in-4-and-6-Months-Old-Line-61-Mice-Apr.2025.pdf | discovery | parkinsons-disease | line-61-mice |
| Longitudinal Evaluation of pTHR217 Tau and Other Tau Sites in PS19 | 2025 | Discovery | Alzheimer's disease | PS19 | Brain, Cortex, Hippocampus, Plasma, CSF, NFL, GFAP, pThr217 tau, pSer202/2025 tau, | Perez Ruiz I., Loeffler T., Breznik L., DaurerM., Prokesch M. | Scantox Neuro GmbH, Grambach, Austria | scantox.com/wp-content/uploads/2025/07/Scantox-Poster-Longitudinal-Evaluation-of-pTHR217-Tau-and-Other-Tau-Sites-in-PS19-Apr.2025.pdf | discovery | alzheimers-disease | ps19 |
| Comparative Analysis of Human and Mouse Fibroblast Lines as In Vitro Models for Lysosomal Storage Diseases: A Focus on Enzyme Activity and Lipid Metabolism | 2025 | Discovery | Gaucher disease, Niemann-Pick disease, Pompe Disease | 4L/PS-NA mice, Cell line, NPC1 mice, Pompe 6neo | Lysosomal storage disease, Lipid accumulation, Glucocerebrosidase, α-glucosidase, Live-cell imaging | Loeffler T., Perez-Ruiz I., Loecker A., Schilcher I., Scheytt R., Daurer M., Flunkert S., Zdouc A., Breznik L., Brunner D., Prokesch M. | Scantox Neuro GmbH, Parkring 12, 8074 Grambach, Austria | scantox.com/wp-content/uploads/2025/04/Scantox-Poster-Comparative-Analysis-of-Human-and-Mouse-Fibroblast-Lines-as-In-Vitro-Models-.-Feb.2025.pdf | discovery | gaucher-disease niemann-pick-disease pompe-disease | 4l-ps-na-mice cell-line npc1-mice pompe-6neo |
| Application of Preclinical Gene Therapy Approaches | 2025 | Discovery | Alzheimer's disease, Amyotrophic lateral sclerosis, Gaucher disease, Other, Parkinson's disease | 4L/PS-NA mice, Cell line, Mice, rat | Administration routes, Surgery, CSF sampling, Cell viability, Cell toxicity, Neurofilament light chain, | Krassnig S., Daurer M., Loeffler T., Flunkert S., Brunner D., Prokesch M. | Scantox Neuro GmbH, Parkring12, 8074 Grambach, Austria | scantox.com/wp-content/uploads/2025/04/Scantox-Poster-Application-of-Preclinical-Gene-Therapy-Approaches-Feb.2025.pdf | discovery | alzheimers-disease amyotrophic-lateral-sclerosis gaucher-disease other parkinsons-disease | 4l-ps-na-mice cell-line mice rat |
| Compound Muscle Action Potential as Translational Biomarker in a Mouse Model of Pompe Disease | 2025 | Discovery | Pompe Disease | Pompe 6neo | Lysosomal storage disease, Electromyography, Alpha-glucosidase, CMAP | Krassnig S., Breznik L., Ljekaj M., Fantina-Woblistin A., Daurer M., Flunkert S., Prokesch M. | Scantox Neuro GmbH, Parkring12, 8074 Grambach, Austria | scantox.com/wp-content/uploads/2025/04/Scantox-Poster-Compound-Muscle-Action-Potential-as-Translational-Biomarker-in-a-Mouse-Model-of-Pompe-Disease-Feb.2025.pdf | discovery | pompe-disease | pompe-6neo |
| Longitudinal Analysis of a Nitroglycerin-Induced Mouse Migraine Model | 2024 | Discovery | Migraine | Mice | Grimace scale, Grooming, Light/dark box, Sex differences | Aaron Fantina-Woblistin, Livia Breznik, Laurenz Jauk, Magdalena Daurer, Roland Rabl, Tina Löffler, Manuela Prokesch | Scantox Neuro GmbH, Neuropharmacology, Grambach, Austria | scantox.com/wp-content/uploads/2024/09/Scantox-Neuro-MTIS_2024-Migraine-animal-model.pdf | discovery | migraine | mice |
| In Vitro Systems Targeting TDP-43 Translocation, Stress Granules, and Stathmin-2 Splicing | 2024 | Discovery | Amyotrophic lateral sclerosis | Cell line, iPSCs | mRNA, alternative splicing, translocation, stress granule formation, cytosolic, nuclear | Andy Brown1, Tina Loeffler2, Irene Schilcher2, Irantzu Perez Ruiz2, Igor Cancar2, Magdalena Daurer2, Stefanie Flunkert2, | 1 Scantox Denmark ApS, Hestehavevej 36, 4623 Lille Skensved, Denmark | scantox.com/wp-content/uploads/2024/11/SfN2024-TDP-in-vitro_poster.pdf | discovery | amyotrophic-lateral-sclerosis | cell-line ipscs |
| Accelerated Aging and Senescence in Cerebral Organoids | 2024 | Discovery | n/a | Cerebral Organoids | D-Galactose induction, senescence | Tina Loeffler, Izaskun Itxaso, Irene Schilcher, Irantzu Perez Ruiz, Magdalena Daurer, Stefanie Flunkert, Manuela Prokesch | Scantox Neuro GmbH, Parkring 12, Grambach, Austria | scantox.com/wp-content/uploads/2024/11/SfN2024-Organoids_poster.pdf | discovery | n-a | cerebral-organoids |
| Modeling Depression in Rats: Chronic Corticosterone Administration as a Tool for Antidepressant Efficacy Assessment | 2024 | Discovery | Depression | Rats | Behavior, Sucrose preference, Open field, Forces Swim test, Grooming, Coat Score | Ewald Auer, Aaron Fantina-Woblistin, Livia Breznik, Magdalena Daurer, Stefanie Flunkert, Manuela Prokesch | Scantox Neuro GmbH, Parkring 12, 8074 Grambach, Austria | scantox.com/wp-content/uploads/2024/11/SfN2024-Depression_poster.pdf | discovery | depression | rats |
| AAV-Human A53T-Mutated Synuclein Disrupts Nigro-Striatal System in Mice | 2024 | Discovery | Parkinson's disease | C57BL6 mice | Parkinson's disease, pathology, histology, unilateral, substantia nigra, caudate putamen | Ewald Auer, Tina Loeffler, Magdalena Daurer, Livia Breznik, Joerg Neddens, Stefanie Flunkert, Manuela Prokesch | Scantox Neuro GmbH, Parkring 12, 8074 Grambach, Austria | scantox.com/wp-content/uploads/2024/11/SfN2024-AAV-A53T-poster.pdf | discovery | parkinsons-disease | c57bl6-mice |
| Advancements in Preclinical Gene Therapy | 2024 | Discovery | n/a | 4L/PS-NA mice, Cell line, Rats | Compound administration routes, surgery techniques, in vivo CSF sampling, cell viability, toxicology, MTT assay, antisense oligonucleotides (ASO), | S Sharghi1, M Daurer1, T Loeffler1, S Flunkert1, D Brunner1, L Bruhn Madsen2, | 1 Scantox Neuro GmbH, A-8074, Parkring 12, Grambach, Austria | scantox.com/wp-content/uploads/2024/11/ESGCT2024_Advancements-in-preclinical-gene-therapy-poster.pdf | discovery | n-a | 4l-ps-na-mice cell-line rats |
| Characterization of an Inducible AAV9-hTDP-43 Mouse Model for ALS | 2024 | Discovery | Amyotrophic lateral sclerosis | C57BL6 mice | Neurodegeneration, motor deficits, astrocytosis, atrophy, motor cortex | Benedikt Kien, Livia Breznik, Magdalena Daurer, Tina Loeffler, Laurenz Jauk, Stefanie Flunkert, Manuela Prokesch | Scantox Neuro GmbH, Neuropharmacology, Grambach, Austria | scantox.com/wp-content/uploads/2024/11/ESGCT2024_AAV-TDP43-poster.pdf | discovery | amyotrophic-lateral-sclerosis | c57bl6-mice |
| Viral Gene Delivery Approach to Mimic α-Synuclein Pathology in a Preclinical Model for Parkinson`s Disease | 2024 | Discovery | Parkinson's disease | C57BL6 mice | Unilateral, substantia nigra, AAV-vector, caudate putamen | Stefanie Krassnig, Tina Loeffler, Magdalena Daurer, Livia Breznik, Joerg Neddens, | Scantox Neuro GmbH, Neuropharmacology, Grambach, Austria | scantox.com/wp-content/uploads/2024/11/ESGCT2024_AAV-A53T-poster.pdf | discovery | parkinsons-disease | c57bl6-mice |
| LPS and Pre-Aggregated Aβ1-42 Lead to an Increased Neuroinflammatory Response in Cerebral Organoids | 2024 | Discovery | Alzheimer's disease, Neuroinflammation | Cerebral Organoids | Neuroinflammation, LPS, Aβ1-42, cerebral organoids | Izaskun Itxaso1,2, Tina Loeffler1, Irene Schilcher1, Magdalena Daurer1, Stefanie Flunkert1, Boris Chagnaud2, Manuela Prokesch1 | 1 Scantox Neuro GmbH, A-8074, Parkring 12, Grambach, Austria | scantox.com/wp-content/uploads/2024/11/FENS2024_Poster_Cerebral-organoids.pdf | discovery | alzheimers-disease neuroinflammation | cerebral-organoids |
| Behavioral and Histological Hallmarks of an Intrastriatal Rotenone Mouse Model for Parkinson's Disease | 2024 | Discovery | Parkinson's disease | C57BL6 mice | Rotenone, ER-stress, intrastriatal injection, motor deficits, neuroinflammation, neurodegeneratios | Paula Jauregi1,2, Roland Rabl1, Magdalena Daurer1, Livia Breznik1, Stefanie Flunkert1, Boris Chagnaud2, Manuela Prokesch1 | 1 Scantox Neuro GmbH, A-8074, Parkring 12, Grambach, Austria | scantox.com/wp-content/uploads/2024/11/FENS2024-poster-ER-stress-Rotenone.pdf | discovery | parkinsons-disease | c57bl6-mice |
| Comparative Analysis of In Vitro Systems for TDP-43 Pathology | 2024 | Discovery | Alzheimer's disease, Amyotrophic lateral sclerosis, Frontotemporal lobar degeneration, Parkinson's disease | iPSCs, Neuroblastoma cells | TDP-43, Stress granules, Cryptic splicing, Sodium arsenite | Stefanie Krassnig, Tina Loeffler, Irene Schilcher, Irantzu Perez Ruiz, Magdalena Daurer, Stefanie Flunkert, Manuela Prokesch | Scantox Neuro GmbH, Neuropharmacology, Grambach, Austria | scantox.com/wp-content/uploads/2024/09/Scantox_Neuro4D_2024-In-vitro-TDP43-Models.pdf | discovery | alzheimers-disease amyotrophic-lateral-sclerosis frontotemporal-lobar-degeneration parkinsons-disease | ipscs neuroblastoma-cells |
| Mating of Göttingen Minipigs at Scantox for use in embryofoetal development studies | 2022 | Regulatory Toxicology | n/a | Göttingen Minipig | Estrous synchronization | Ellemann-Laursen, Sisse | Scantox A/S, Denmark | scantox.com/wp-content/uploads/2022/09/2022-09-SE-ETS-repro-Antwerp-1200x1400mm-v.3-final.pdf | regulatory-toxicology | n-a | gottingen-minipig |
